Adrenocortical oncocytoma: Case report with immunocytochemical and ultrastructural study

Bégin, Louis R.

doi:10.1007/bf01606884

Cited by 44 publications

(25 citation statements)

References 14 publications

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“…Nevertheless, the cases were generally negative for S100 and chromogranin. Bégin [17] and Lin et al [30] reported immunoreactivity to cytokeratins 8 and 18 (or CAM 5.2), in contrast to the findings of other authors.…”

Section: Histologymentioning

confidence: 81%

“…Most of them are incidentally detected [13][14][15][16][17][18] , since only 17% are functional adrenal masses [19] . Their occurrence in all ages has been described, without a precise age distribution (mean age at diagnosis 47 years, range 27-72 years), and have been observed to occur more frequently in females (2.5: 1) and in the left gland (3.5: 1).…”

Section: Incidencementioning

confidence: 99%

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Adrenal Oncocytic Neoplasm: A Systematic Review

Mearini¹,

Sordo

Costantini³

et al. 2012

Urol Int

102

151

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Introduction: Oncocytic neoplasms as tumors arising in the adrenal glands are rare, usually considered as nonfunctional and benign. In the current literature, there are extremely limited reports of adrenal oncocytic neoplasms; as to date, only 147 cases have been described. The rarity of the event prompted this study which reviews and presents the incidence, histology, diagnosis and therapy of adrenal oncocytic neoplasms. Materials and Methods: A review by systematic literature search was done using the MEDLINE®/Cochrane libraries from 1950 to date using the medical subject headings ‘oncocytoma', ‘adrenal gland', ‘adrenal oncocytoma', ‘adrenal oncocytic neoplasm' and ‘adrenal oncocytic carcinoma'. Results: Adrenal oncocytic neoplasm is a rare disease, usually incidentally detected because only 17% are functional adrenal masses. The typical oncocyte displays abundant granular eosinophilic cytoplasm, due to the accumulation of mitochondria. Computed tomography and magnetic resonance imaging are not able to identify or differentiate benign and malignant oncocytic neoplasms. The mainstay of therapy is adrenalectomy, recently performed by laparoscopy. The prognosis is good for benign tumors, while adrenocortical oncocytic carcinoma has a poor survival rate of only 5 years. Conclusions: Adrenal oncocytic neoplasm, a rare and mostly benign tumor, usually presents as an incidental, large adrenal mass; surgery is the mainstay of therapy, by means of laparoscopy which is now the most diffuse approach to adrenalectomy.

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Section: Histologymentioning

confidence: 81%

Section: Incidencementioning

confidence: 99%

Adrenal Oncocytic Neoplasm: A Systematic Review

Mearini¹,

Sordo

Costantini³

et al. 2012

Urol Int

102

151

View full text Add to dashboard Cite

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“…Twenty-seven cases of adrenocortical oncocytic neoplasms have been reported to date, which comprised 22 oncocytomas, 2 oncocytic neoplasms of uncertain malignant potential, and 3 oncocytic carcinomas (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). All arose in the adrenal gland with the exception of one oncocytoma that originated in heterotopic right supra-adrenal retroperitoneal tissue (11).…”

Section: Discussionmentioning

confidence: 99%

“…The majority of those reported have followed a benign clinical course (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). To date, three oncocytic adrenocortical carcinomas have been described; however, these cases emphasized only either the clinical presentation, the fine needle aspiration findings, or the ultrastructural features (2,7,8).…”

mentioning

confidence: 99%

Oncocytic Adrenocortical Carcinoma: A Morphologic, Immunohistochemical and Ultrastructural Study of Four Cases

2002

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Oncocytic adrenocortical neoplasms are rare, usually non-functioning tumors, found predominantly in adults. The majority of those reported have followed a benign clinical course (1-14). To date, three oncocytic adrenocortical carcinomas have been described; however, these cases emphasized only either the clinical presentation, the fine needle aspiration findings, or the ultrastructural features (2, 7, 8).We present the clinical, histologic, immunohistochemical, and ultrastructural features of four cases of oncocytic adrenocortical carcinoma. The cytopathologic findings of one case have been previously reported (7). MATERIALS AND METHODSThe consultation file of two of the authors (JA-S, AGA) and the surgical pathology files of the University of Texas Southwestern Medical Center, Dallas, and M.D. Anderson Cancer Center, Houston, Texas, were searched for oncocytic adrenocortical carcinomas. Four cases with available archival materials were identified. The cytopathologic findings of one case (case 1) have previously been published (7). Four-micrometer thick sections were cut from the formalin-fixed, paraffin-embedded blocks and stained with hematoxylin and eosin. Additional paraffin sections of selected blocks were obtained for immunohistochemical studies, which were performed on an automated immunostainer (Ventana, Biotek System, Tucson, AZ) using the standard avidin-biotin peroxidase complex technique and the heat-induced epitope retrieval buffer. The primary antibodies are listed in Table 1. For electron microscopic study, tissue of three cases was fixed in 3% glutaraldehyde, postfixed in 1% osmium tetroxide, and thin sections were stained with lead citrate

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“…В большинстве случаев опухоль характеризуется отсутствием реакции с антителами S-100 и хромограни-ном А. Begin [13] и В. Lin и соавт. [12] сообщают о том, что опухоли позитивны в реакциях с антителами к цитокера-тину 8 и 18.…”

Section: Lin-weiss-bisceglia система диагностики онкоцитарных новообрunclassified