Adrenocortical oncocytic carcinoma with recurrent metastases: a case report and review of the literature

Argyriou, Pinelopi; Zisis, Charalambos; Alevizopoulos, Nektarios; Kefaloyannis, Emmanuel; Gennatas, Constantine; Petraki, Constantina

doi:10.1186/1477-7819-6-134

Cited by 17 publications

(19 citation statements)

References 30 publications

(37 reference statements)

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“…According to the currently used classification, there are three histological categories: pure and benign oncocytoma, oncocytic neoplasm of uncertain malignant potential [36][37][38] and oncocytic carcinoma [39][40][41][42] .…”

Section: Histologymentioning

confidence: 99%

Adrenal Oncocytic Neoplasm: A Systematic Review

Mearini¹,

Sordo

Costantini³

et al. 2012

Urol Int

102

151

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Introduction: Oncocytic neoplasms as tumors arising in the adrenal glands are rare, usually considered as nonfunctional and benign. In the current literature, there are extremely limited reports of adrenal oncocytic neoplasms; as to date, only 147 cases have been described. The rarity of the event prompted this study which reviews and presents the incidence, histology, diagnosis and therapy of adrenal oncocytic neoplasms. Materials and Methods: A review by systematic literature search was done using the MEDLINE®/Cochrane libraries from 1950 to date using the medical subject headings ‘oncocytoma', ‘adrenal gland', ‘adrenal oncocytoma', ‘adrenal oncocytic neoplasm' and ‘adrenal oncocytic carcinoma'. Results: Adrenal oncocytic neoplasm is a rare disease, usually incidentally detected because only 17% are functional adrenal masses. The typical oncocyte displays abundant granular eosinophilic cytoplasm, due to the accumulation of mitochondria. Computed tomography and magnetic resonance imaging are not able to identify or differentiate benign and malignant oncocytic neoplasms. The mainstay of therapy is adrenalectomy, recently performed by laparoscopy. The prognosis is good for benign tumors, while adrenocortical oncocytic carcinoma has a poor survival rate of only 5 years. Conclusions: Adrenal oncocytic neoplasm, a rare and mostly benign tumor, usually presents as an incidental, large adrenal mass; surgery is the mainstay of therapy, by means of laparoscopy which is now the most diffuse approach to adrenalectomy.

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Section: Histologymentioning

confidence: 99%

Adrenal Oncocytic Neoplasm: A Systematic Review

Mearini¹,

Sordo

Costantini³

et al. 2012

Urol Int

102

151

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“…In 21.9% of cases, diagnosis was performed by abdominal pain or palpable mass and in 21.9% of cases by excessive hormone secretion symptoms (36.8%). In 10 cases, there was evidence of metastasis , and in two cases, there was invasion into the inferior vena cava , while seven cases presented tumor recurrence after resection .…”

Section: Discussionmentioning

confidence: 99%

Functional plurihormonal adrenal oncocytoma: case report and literature review

Costanzo

Paissan

Knoblovits

2017

Clinical Case Reports

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“…It can also be found in pituitary, eyelids, parathyroid, thymus, spinal cord, and other parts. [ 1 , 5 , 6 ] So, the adrenal cortical oncocytoma is a rare disease with an unknown incidence. No identified environmental or genetic risk factor was reported for the etiology of the tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Although 3 cases were diagnosed malignant potential in condition that they met the secondary criteria, we did not see any metastasis and recurrence during the follow-up. Argyriou et al [ 5 ] reported 1 case with a tumor relapse, and it was the only 1 case in the literature. However, the patient had a history of adrenocortical carcinoma, and the diagnosis criteria used by the author aroused a controversy.…”

Section: Discussionmentioning

confidence: 99%

Adrenocortical oncocytoma

Hong

Hao²,

Hu³

et al. 2017

Medicine

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Rationale:Adrenocortical oncocytoma is an extremely rare tumor of the adrenal gland. Its diagnostic criteria and biological behavior has not yet reached a consensus. The purpose of this study is to investigate the clinical characteristics of adrenocortical oncocytoma.Patient concerns:The clinical data from 11 cases of adrenocortical oncocytoma were retrospectively analyzed. Five patients found the tumor incidentally during the healthy examination, and 3 cases found the tumor during the diagnostic work-up for the evaluation of flank pain or hypertension. A female patient manifested virilization, and Cushing's syndrome showed in two patients. The tumor diameter was ranging from 2.0-13.0 cm.Diagnoses:The serum cortisol, plasma aldosterone and catecholamine metabolites were used to evaluate the function of the tumors, and enhanced CT scan was used to confirm the tumor boundary, enhancement, and lymph nodes condition.Interventions:Seven cases underwent laparoscopic adrenal tumor resection, 4 patients underwent open surgery. Pathological report indicated adrenocortical oncocytoma in all cases, three of which were potentially malignant.Outcomes:The patients were followed up for 19-72 months, no local recurrence and distant metastases were detected in 3 cases of malignant potential cases.Lessons:The majority of adrenocortical oncocytoma with or without function are benign, and close follow-up observation is essential.

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Adrenocortical oncocytic carcinoma with recurrent metastases: a case report and review of the literature

Abstract: Background: Adrenal cortex oncocytic carcinoma (AOC) represents an exceptional pathological entity, since only 22 cases have been documented in the literature so far.

Cited by 17 publications

References 30 publications

Adrenal Oncocytic Neoplasm: A Systematic Review

Adrenal Oncocytic Neoplasm: A Systematic Review

Functional plurihormonal adrenal oncocytoma: case report and literature review

Adrenocortical oncocytoma

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