Adrenocortical lipoid hyperplasia induced in rats by aniline

Kovács, Kálmán; Yeghiayan, E.; Hatakeyama, Shigeru; Selye, Hans

doi:10.1007/bf02114167

Cited by 10 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Morphological studies of adrenals from patients treated with aminoglutethimide have shown increased gland size, increased thickness of the zona fasciculata associated with increased numbers of cells containing cytoplasmic lipid with concomitant decrease in thickness of the zona glomerulosa. 190 The findings were also characterized by adrenal enlargement, accumulation of cytoplasmic lipid droplets and cholesterol crystals, associated with mitochondrial degeneration, proliferation of the smooth endoplasmic reticulum, dilatation of the Golgi and an increase in lysosomes, most pronounced in inner cortical zones. A thickened zona glomerulosa is characterized by increased number of cells with pale staining and vacuolated cytoplasm containing excess lipid.…”

Section: Lipid or Lipoid Hyperplasiamentioning

confidence: 96%

Endocrine Glands

Greaves¹

2012

Histopathology of Preclinical Toxicity Studies

View full text Add to dashboard Cite

Section: Lipid or Lipoid Hyperplasiamentioning

confidence: 96%

Endocrine Glands

Greaves¹

2012

Histopathology of Preclinical Toxicity Studies

View full text Add to dashboard Cite

“…In chronic toxicity and carcinogenicity studies of rats, the following toxic effects were also observed: suppression of body weight gain [7]; decrease in steroidogenesis and reduced amount of lipid accumulation in the ovaries and adrenal glands [10,16]; hemosiderosis in the liver and kidneys; splenic fibrosis; increased incidence of endometrial stromal polyps, splenic fibrosarcomas, and hemangiosarcomas [6,7,12].…”

mentioning

confidence: 99%

Neurotoxicity Induced by a Single Oral Dose of Aniline in Rats.

Okazaki

Yamashita

Sudo

et al. 2001

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. The neurotoxicity of aniline and its age-dependent responses were investigated in male rats. Groups of 6 rats, 4-week-old, were treated once with aniline (500, 750 or 1,000 mg/kg) or olive oil by gavage. Additional groups of 6 rats, 7-or 10-week-old, were treated once with 800 mg/kg of aniline or olive oil. Paralytic gait or hindlimb paralysis was observed between post-treatment days 8 and 15 in two out of six rats receiving 1,000 mg/kg of aniline at 4 weeks of age. On post-treatment day 15, spongy change in the white matter of the spinal cord was observed in all rats receiving 750 or 1,000 mg/kg of aniline at 4 weeks of age. The lateral and ventral columns of the thoracic spinal cord were the most severely affected. Spongy change in the facial nerve and spinal trigeminal tracts of pons and medulla oblongata, and mild degeneration of the peripheral nerves was found in 3 out of 6 rats receiving 1,000 mg/kg of aniline. At the ultrastructural level, the spongy change was due to distention of the myelin sheath and splitting of the intraperiod line. Axons were well preserved in the affected nerve fibers. No abnormalities were seen in the neuronal cell bodies. Although transient cyanosis was observed in all rats receiving 800 mg/kg of aniline at 7-or 10-week-old, as well as in rats receiving 750 or 1,000 mg/kg of aniline at 4-week-old, no treatment-related neurobehavioral or morphologic abnormalities were found in the former. These findings demonstrate the neurotoxicity of orally administered aniline for rats, depending upon the age of the animal at the time of administration. KEY WORDS: aniline, hindlimb paralysis, neurotoxicity, rat, spongy change with myelin vacuolation.

show abstract

“…However, spironolactone bodies may also very rarely occur in the deeper layers of the adrenal cortex and typical fingerprint configurations, indistinguishable from those seen in the zona glomerulosa after prolonged spironolactone treatment, can be detected in the cytoplasm ofadrenocortical (Kovacs, Khandekar, Szabo, Garg, and Tuchweber, 1972) and corpus luteum cells (Kovacs, Horvath, Szabo, Garg, and Tuchweber, 1973) of the rat following administration of cycloheximide, a protein synthesis inhibitor. It is also known that large fingerprint-like bodies can be identified in different organs following treatment with various compounds, such as ethionine, aniline, pregnenolone 16-alpha-carbonitrile, triparanol, chloroquine, etc (Steiner, Miyai, and Phillips, 1964;Kovacs, Blascheck, Yeghiayan, Hatakeyama, and Gardell, 1971a;Garg, Kovacs, and Tuchweber, 1972;Hruban, Slesers, and Hopkins, 1972). Shikata, Kanetaka, Endo, and Nagashima, (1972) found fingerprints in several organs of man and rat following the administration of 4.4'-diethylaminoethoxy hexoestrol, a coronary vasodilatator used to alleviate the pain of angina pectoris.…”

Section: Discussionmentioning

confidence: 99%

Fine structure and morphogenesis of spironolactone bodies in the zona glomerulosa of the human adrenal cortex

Kovács¹,

Horváth²,

Singer³

1973

J Clin Pathol

Self Cite

View full text Add to dashboard Cite

SYNOPSIS Numerous spironolactone bodies have been detected in the zona glomerulosa cells of the adrenal cortex of a 36-year-old spironolactone-treated woman whose non-tumorous right adrenal gland was removed surgically because of primary hyperaldosteronism. Electron microscopy revealed spherical laminated whorls which consisted of a central core composed of an amorphous electrondense material surrounded by numerous smooth-walled concentriC membranes. Continuous with and deriving from the endoplasmic reticulum, they were present in viable cells and were not associated with ultrastructural features indicating cellular injury. Cytoplasmic inclusions similar to spironolactone bodies can be detected in other organs after the administration of various compounds. Thus, they can be regarded as neither specific to spironolactone treatment nor exclusively inducible in the zona glomerulosa of the adrenal cortex.Spironolactone (Aldactone) bodies were first detected by Janigan (1963) in the zona glomerulosa of adrenal cortex of human subjects following prolonged treatment with spironolactone, an aldosterone antagonist. To our knowledge findings on the ultrastructure of these round, laminated, acidophilic inclusions have only been reported so far by Jenis and Hertzog (1969) and by Davis and Medline (1970). These authors examined human adrenal glands obtained from necropsies, and, as several hours elapsed between death and fixation of tissues, the preservation could not be considered optimal.Recently, a non-tumorous adrenal gland, removed surgically from a 36-year-old woman because of primary hyperaldosteronism, was studied by electron microscopy in our laboratory. The zona glomerulosa of the adrenal cortex was found to contain numerous spironolactone bodies, thus providing an opportunity to investigate the fine structure, morphogenesis, and evolution of these distinctive cytoplasmic inclusions in well preserved specimens. Case HistoryA 36-year-old housewife presented with a two-year history of spontaneous flushing and sweating attacks Received for publication 10 September 1973. and the recent onset of pounding headaches. Blood pressure was 220/120 mm Hg bilaterally, unaffected by posture. Laboratory investigations revealed a normal haemogram, ESR, serum calcium and phosphorus, serum uric acid, ac and pc blood sugar, plasma cortisol (8 am and 8 pm), urinary 17-ketogenic and 17-ketosteroids, and VMA estimations including a search for raised metanephrine and normetanephrine levels. Rogitine failed to cause a sustained drop in her blood pressure. Serum electrolytes were normal initially and remained so throughout, with the exception of two low K values of 3-1 and 3-3 m-equiv/1 without evidence of associated metabolic alkalosis while off all medications.Renin activity was depressed on a low (10 m-equiv/ 1) sodium diet but showed some postural response: 0 54 ng angiotensin I supine (normal: 2-58 ± 0 70) and 2-99 ng angiotensin I upright (normal: 5-26 + 0 65) (Dr A.

show abstract

Adrenocortical lipoid hyperplasia induced in rats by aniline

Cited by 10 publications

References 0 publications

Endocrine Glands

Endocrine Glands

Neurotoxicity Induced by a Single Oral Dose of Aniline in Rats.

Fine structure and morphogenesis of spironolactone bodies in the zona glomerulosa of the human adrenal cortex

Contact Info

Product

Resources

About