Adrenocortical function in asthmatic children: low levels of adrenocortical hormones in children with persistent attacks

Nomura, Shosaku; Fujitaka, Michiko; Sakura, Nobuo; Ueda, Kazuhiro

doi:10.1007/s004310050610

Cited by 9 publications

(5 citation statements)

References 15 publications

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“…These results are similar to the established reference intervals for cortisol and cortisone in healthy American subjects by LC-MS/MS assay [23, 24] or in healthy Japanese subjects by HPLC assay [20, 28]. In our study, no significant differences between male and female's cortisol or cortisone levels were found, indicating that the levels of cortisol or cortisone in serum are regardless of gender [22]. …”

Section: Resultssupporting

confidence: 90%

“…It is well known that the cortisone/cortisol ratio is decreased in hyperadrenalism and under physiological stress but is increased in hypoadrenalism. Therefore, the cortisone/cortisol ratio can give useful information in evaluating the adrenal function of patients with various diseases [20, 22, 24, 28]. …”

Section: Resultsmentioning

confidence: 99%

“…All serum samples were collected at 9:00–11:00 a.m. using SST tubes (BD Inc., NJ, USA) and stored at −70°C until assay. Although most of the samples were collected from women, all the samples were studied as recruited, due to no meaningful difference between male and female in the concentrations of cortisol and cortisone [22]. Informed consent was obtained from all study participants, and the study protocols were approved by the Institutional Review Board of Seoul Medical Science Institute.…”

Section: Methodsmentioning

confidence: 99%

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Simultaneous Determination of Cortisol and Cortisone from Human Serum by Liquid Chromatography-Tandem Mass Spectrometry

Lee

Lim

Shin

et al. 2014

Journal of Analytical Methods in Chemistry

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A fast, sensitive, and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was validated and then the levels of cortisol and cortisone from sera of healthy adults were determined by the LC-MS/MS method. One hundred μL of serum sample was directly extracted by adding 2 mL ethyl acetate, followed by chromatographic separation on a C18 column with a mobile phase consisting of 5 mM ammonium acetate and methanol (25 : 75, v/v). The precision, accuracy, and average recovery of the method were 1.5–5.3%, 95.4–102.5%, and 96.4% for cortisol, and 1.9–6.0%, 89.2–98.8%, and 79.9% for cortisone, respectively. The method was linear from 1.0 to 500.0 ng/mL (r2 = 0.999) for cortisol and 2.5 to 100.0 ng/mL (r2 = 0.998) for cortisone. The limits of detection (LOD) and quantification (LOQ) were 0.2 and 1.0 ng/mL for cortisol, and 1.0 and 2.5 ng/mL for cortisone, respectively. The average cortisol concentration (133.9 ± 63.7 ng/mL) of samples collected between 9:00 and 11:00 a.m. was higher approximately 4.4 times than that of cortisone (30.5 ± 10.7 ng/mL) (P < 0.0001). The average cortisone/cortisol ratio was 0.225. Therefore, the LC-MS/MS method may be useful for the diagnosis of some adrenal diseases and the assessment of 11β-hydroxysteroid dehydrogenase (11β-HSD) activity in clinical laboratories.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Simultaneous Determination of Cortisol and Cortisone from Human Serum by Liquid Chromatography-Tandem Mass Spectrometry

Lee

Lim

Shin

et al. 2014

Journal of Analytical Methods in Chemistry

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“…We found no association between basal cortisol measured at age 11 years and asthma at age 11 years. Previous studies have shown lower [9][10][11], comparable [12][13][14][15][16] and higher [17,18] cortisol levels in asthmatics than nonasthmatics. Therefore, we have performed a post hoc metaanalysis to obtain a stronger conclusion about the association between cortisol and asthma.…”

Section: Discussionmentioning

confidence: 99%

“…Not only have lower [9][10][11] or normal cortisol levels [12][13][14][15][16] been reported in asthmatics compared to non-asthmatics, but also higher [17,18] cortisol levels have been reported. Since all these studies investigated different aspects of the circadian pattern of cortisol secretion in relation to asthma, their results are incomparable.…”

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confidence: 99%

Basal or stress-induced cortisol and asthma development: the TRAILS study

et al. 2012

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We examined the association between: 1) cortisol levels and asthma or asthma development; 2) cortisol levels upon stress and asthma. In addition, we performed a post hoc meta-analysis on results from the literature.Cortisol, cortisol upon stress, asthma (doctor diagnosis of asthma and/or symptoms and/or treatment in the past 12 months) and asthma development (asthma at a specific survey while not having asthma at the previous survey(s)) were assessed in the TRAILS study (n52230, mean age at survey 1 11 years, survey 2 14 years and survey 3 16 years). Logistic regression models were used to study associations between: 1) cortisol (cortisol awakening response, area under the curve (AUC) with respect to the ground (AUCg) or with respect to the increase (AUCi), and evening cortisol) and asthma or asthma development; 2) cortisol upon stress (AUCg or AUCi) and asthma. The meta-analyses included nine case-control articles on basal cortisol in asthma.No significant association was found between: 1) cortisol and asthma (age 11 years) or asthma development (age 14 or 16 years); 2) cortisol upon stress and asthma (age 16 years). The metaanalysis found lower morning and evening cortisol levels in asthmatics compared to nonasthmatics; however, the summary estimates were not significant.We found no evidence supporting a role for cortisol in asthma and asthma development.

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Endogenous glucocorticoids inhibit scratching behavior induced by the administration of compound 48/80 in mice

Hirayama

Sudo

Sueyasu

et al. 2003

European Journal of Pharmacology

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Adrenocortical function in asthmatic children: low levels of adrenocortical hormones in children with persistent attacks

Abstract: During an asthma attack, adrenocortical hormone concentrations increase in proportion to the severity of the attack but subsequently decrease with time. It is speculated that the inability to sustain an elevated cortisol level may lead to the persistent asthma attacks.

Cited by 9 publications

References 15 publications

Simultaneous Determination of Cortisol and Cortisone from Human Serum by Liquid Chromatography-Tandem Mass Spectrometry

Simultaneous Determination of Cortisol and Cortisone from Human Serum by Liquid Chromatography-Tandem Mass Spectrometry

Basal or stress-induced cortisol and asthma development: the TRAILS study

Endogenous glucocorticoids inhibit scratching behavior induced by the administration of compound 48/80 in mice

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