Adrenocortical Carcinoma

Berruti, Alfredo; Tiberio, Guido Alberto Massimo; Sigala, Sandra

doi:10.3390/cancers13051077

Cited by 4 publications

(3 citation statements)

References 25 publications

(22 reference statements)

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“…Adrenocortical carcinoma (ACC) is a rare endocrine tumor, originating from the adrenal cortex, with a poor prognosis and an incidence between 0.7 and 2 cases per million each year (Berruti et al 2021).…”

Section: Flna In Adrenocortical Carcinomasmentioning

confidence: 99%

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Role of filamin A in the pathogenesis of neuroendocrine tumors and adrenal cancer

et al. 2022

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Cell cytoskeleton proteins are involved in tumor pathogenesis, progression and pharmacological resistance. Filamin A (FLNA) is a large actin-binding protein with both structural and scaffold functions implicated in a variety of cellular processes, including migration, cell adhesion, differentiation, proliferation and transcription. The role of FLNA in cancers has been studied in multiple types of tumors. FLNA plays a dual role in tumors, depending on its subcellular localization, post-translational modification (as phosphorylation at Ser2125) and interaction with binding partners. This review summarizes the experimental evidence showing the critical involvement of FLNA in the complex biology of endocrine tumors. Particularly, it will be discussed the role of FLNA in regulating expression and signaling of the main pharmacological targets in pituitary neuroendocrine tumors (PitNETs), pancreatic neuroendocrine tumors (Pan-NETs), pulmonary neuroendocrine tumors (P-NETs) and adrenocortical carcinomas (ACC), with implications on responsiveness to currently used drugs in the treatment of these tumors.

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Section: Flna In Adrenocortical Carcinomasmentioning

confidence: 99%

“…ACC is a rare endocrine tumor, originating from the adrenal cortex, with a poor prognosis and an incidence between 0.7 and 2 cases per million each year ( Berruti et al 2021 ). To date, the best curative options are complete tumor resection and treatment with mitotane ( Fassnacht et al 2018 , Amodru et al 2020 ).…”

Section: Flna In Adrenocortical Carcinomasmentioning

confidence: 99%

Role of filamin A in the pathogenesis of neuroendocrine tumors and adrenal cancer

et al. 2022

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“…Other types of adrenal malignant tumors are sporadic ( 5 , 6 ). ACC is the major adrenal malignant tumor in clinical work, and even so, its incidence is low, with an annual incidence estimated to be only 2 in a million ( 7 , 8 ). ACC has an ominous prognosis, with a five-year survival rate ranging from 16 to 38% and a median overall survival of about 3–4 years ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

Construction and validation of a prognostic model for predicting overall survival of primary adrenal malignant tumor patients: A population-based study with 1,080 patients

Xie

Zhang²,

Cao³

2022

Front. Surg.

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ObjectivePrimary adrenal malignant tumor is rare. The factors affecting the prognosis remain poorly defined. This study targeted to construct and corroborate a model for predicting the overall survival of adrenal malignant tumor patients.MethodsWe investigated the SEER database for patients with primary adrenal malignant tumor. 1,080 patients were divided into a construction cohort (n = 756) and a validation cohort (n = 324), randomly. The prognostic factors for overall survival were evaluated using univariate and multivariate Cox analyses. The nomogram was constructed and then validated with C-index, calibration curve, time-dependent ROC curve, and decision curve analysis in both cohorts. Then we divided the patients into 3 different risk groups according to the total points of the nomogram and analyzed their survival status by Kaplan-Meier curve with log-rank test.ResultsThe baseline characteristics of these two cohorts were not statistically different (P > 0.05). Using univariate and multivariate Cox analyses, 5 variables, including age, tumor size, histological type, tumor stage, and surgery of primary site, were distinguished as prognostic factors (P < 0.05). Based on these variables, we constructed a nomogram to predict the 3- year, 5- year, and 10-year overall survival. The C-indexes were 0.780 (0.760–0.800) in the construction cohort and 0.780 (0.751–0.809) in the validation cohort. In both cohorts, the AUC reached a fairly high level at all time points. The internal and external calibration curves and ROC analysis showed outstanding accuracy and discrimination. The decision curves indicated excellent clinical usefulness. The best cut-off values for the total points of the nomogram were 165.4 and 243.1, and the prognosis was significantly different for the three different risk groups (P < 0.001).ConclusionWe successfully constructed a model to predict the overall survival of primary adrenal malignant tumor patients. This model was validated to perform brilliantly internally and externally, which can assist us in individualized clinical management.

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Estrogen receptor beta expression and role in cancers

Monteiro,

Stepanauskaite,

Archer

et al. 2024

The Journal of Steroid Biochemistry and Molecular Biology

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Adrenocortical Carcinoma

Abstract: Adrenocortical carcinoma (ACC) is an extremely rare disease, the incidence of which is 0 [...]

Cited by 4 publications

References 25 publications

Role of filamin A in the pathogenesis of neuroendocrine tumors and adrenal cancer

Role of filamin A in the pathogenesis of neuroendocrine tumors and adrenal cancer

Construction and validation of a prognostic model for predicting overall survival of primary adrenal malignant tumor patients: A population-based study with 1,080 patients

Estrogen receptor beta expression and role in cancers

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