Adrenoceptors—New roles for old players

Michel, Martin C.; Bond, Richard A.; Summers, Roger J.

doi:10.1111/bph.14701

Cited by 9 publications

(9 citation statements)

References 22 publications

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“…Different comparative analyses showed that Amiodarone, despite interacting with the ANS centrally [49] and peripherally [50,51] did not affect HRV. On the other hand, Flecainide and Propafenone have vagolytic [52] and beta-blocking [53] properties, which could further modulate sympathetic and parasympathetic activity in the heart [54,55] decreasing all the parameters of HRV in the time domain and the frequency domain including the markers of vagal activity [56]. On the contrary, Oymatrine, compared to Propafenone, increases HRV [57].…”

Section: Emotional Dysegulation and Heart Rate Variabilitymentioning

confidence: 99%

Is Low Heart Rate Variability Associated with Emotional Dysregulation, Psychopathological Dimensions, and Prefrontal Dysfunctions? An Integrative View

Cattaneo¹,

Franquillo

Grecucci

et al. 2021

JPM

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Several studies have suggested a correlation between heart rate variability (HRV), emotion regulation (ER), psychopathological conditions, and cognitive functions in the past two decades. Specifically, recent data seem to support the hypothesis that low-frequency heart rate variability (LF-HRV), an index of sympathetic cardiac control, correlates with worse executive performances, worse ER, and specific psychopathological dimensions. The present work aims to review the previous findings on these topics and integrate them from two main cornerstones of this perspective: Porges’ Polyvagal Theory and Thayer and Lane’s Neurovisceral Integration Model, which are necessary to understand these associations better. For this reason, based on these two approaches, we point out that low HRV is associated with emotional dysregulation, worse cognitive performance, and transversal psychopathological conditions. We report studies that underline the importance of considering the heart-brain relation in order to shed light on the necessity to implement psychophysiology into a broader perspective on emotions, mental health, and good cognitive functioning. This integration is beneficial not only as a theoretical ground from which to start for further research studies but as a starting point for new theoretical perspectives useful in clinical practice.

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Section: Emotional Dysegulation and Heart Rate Variabilitymentioning

confidence: 99%

Is Low Heart Rate Variability Associated with Emotional Dysregulation, Psychopathological Dimensions, and Prefrontal Dysfunctions? An Integrative View

Cattaneo¹,

Franquillo

Grecucci

et al. 2021

JPM

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“…Different reasons could explain the divergence between humans and rodents. While β3-adrenoceptors play a major role in rodent AT, adult humans have white AT in which β3-adrenoceptors are poorly expressed and play only a minor role in lipolysis [54,55]. In spite of this, our results suggest a relevant role for this subtype in the control of obesity, since the β3-, but not β1-nor β2-adrenoceptor expression in hAT, inversely correlates to body mass index.…”

Section: Discussionmentioning

confidence: 51%

“…Until now, pharmacological modulation of β-adrenoceptors, especially the β3 subtype, had been a promising strategy to the treatment of obesity, and considerable efforts had been made to develop β3-adrenoceptor agonists. Unfortunately, this approach has not yet been successful [53,54]. Different reasons could explain the divergence between humans and rodents.…”

Section: Discussionmentioning

confidence: 99%

NT3/TrkC pathway modulates the expression of UCP-1 and adipocyte size in human and murine adipose tissue

Bové

Montó

Guillem-Llobat

et al. 2020

Preprint

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NT3, through activation of its tropomyosin-related kinase receptor C (TrkC), modulates neuronal survival and neural stem cell differentiation. It is widely distributed in peripheral tissues (specially vessels and pancreas) and this ubiquitous pattern suggests a role for NT3, outside the nervous system and related to metabolic functions. The presence of the NT3/TrkC pathway in the adipose tissue (AT) has never been investigated. Present work studies in human and murine adipose tissue (AT) the presence of elements of the NT3/TrkC pathway and its role on lipolysis and adipocyte differentiation. qRT-PCR and immunoblot indicate that NT3 was present in human retroperitoneal AT and decreases with age. NT3 was also present in rat isolated adipocytes and retroperitoneal, interscapular, perivascular and perirenal AT. Histological analysis evidences that NT3 was mainly present in vessels irrigating AT close associated to sympathetic fibers. Similar mRNA levels of TrkC and β-adrenoceptors were found in all ATs assayed and in isolated adipocytes. NT3, through TrkC activation, exert a mild effect in lipolysis. Addition of NT3 during the differentiation process of human pre-adipocytes resulted in smaller adipocytes and increased uncoupling protein-1 (UCP-1) without changes in β-adrenoceptors. Similarly, transgenic mice with reduced expression of NT3 (Ntf3 knock-in lacZ reporter mice) or lacking endothelial NT3 expression (Ntf3flox1/flox2;Tie2-Cre+/0) displayed enlarged white and brown adipocytes and lower UCP-1 expression.ConclusionsNT3, mainly released by blood vessels, activates TrkC and regulates adipocyte differentiation and browning. Disruption of NT3/TrkC signaling conducts to hypertrophied white and brown adipocytes with reduced expression of the thermogenesis marker UCP-1

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“…Until now, pharmacological modulation of β‐adrenoceptors, especially the β3 subtype, had been a promising strategy to the treatment of obesity, and considerable efforts had been made to develop β3-adrenoceptor agonists but this approach has not yet been successful ( 54 , 55 ). However, while β3‐adrenoceptors play a major role in rodent AT, in adult human AT β3‐adrenoceptors are poorly expressed and play only a minor role in lipolysis ( 55 , 56 ).…”

Section: Discussionmentioning

confidence: 99%

NT3/TrkC Pathway Modulates the Expression of UCP-1 and Adipocyte Size in Human and Rodent Adipose Tissue

et al. 2021

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Neurotrophin-3 (NT3), through activation of its tropomyosin-related kinase receptor C (TrkC), modulates neuronal survival and neural stem cell differentiation. It is widely distributed in peripheral tissues (especially vessels and pancreas) and this ubiquitous pattern suggests a role for NT3, outside the nervous system and related to metabolic functions. The presence of the NT3/TrkC pathway in the adipose tissue (AT) has never been investigated. Present work studies in human and murine adipose tissue (AT) the presence of elements of the NT3/TrkC pathway and its role on lipolysis and adipocyte differentiation. qRT-PCR and immunoblot indicate that NT3 (encoded by NTF3) was present in human retroperitoneal AT and decreases with age. NT3 was also present in rat isolated adipocytes and retroperitoneal, interscapular, perivascular, and perirenal AT. Histological analysis evidences that NT3 was mainly present in vessels irrigating AT close associated to sympathetic fibers. Similar mRNA levels of TrkC (encoded by NTRK3) and β-adrenoceptors were found in all ATs assayed and in isolated adipocytes. NT3, through TrkC activation, exert a mild effect in lipolysis. Addition of NT3 during the differentiation process of human pre-adipocytes resulted in smaller adipocytes and increased uncoupling protein-1 (UCP-1) without changes in β-adrenoceptors. Similarly, transgenic mice with reduced expression of NT3 (Ntf3 knock-in lacZ reporter mice) or lacking endothelial NT3 expression (Ntf3flox1/flox2;Tie2-Cre+/0) displayed enlarged white and brown adipocytes and lower UCP-1 expression.ConclusionsNT3, mainly released by blood vessels, activates TrkC and regulates adipocyte differentiation and browning. Disruption of NT3/TrkC signaling conducts to hypertrophied white and brown adipocytes with reduced expression of the thermogenesis marker UCP-1.

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Adrenoceptors—New roles for old players

Abstract: Linked Articles This article is part of a themed section on Adrenoceptors—New Roles for Old Players. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.14/issuetoc

Cited by 9 publications

References 22 publications

Is Low Heart Rate Variability Associated with Emotional Dysregulation, Psychopathological Dimensions, and Prefrontal Dysfunctions? An Integrative View

Is Low Heart Rate Variability Associated with Emotional Dysregulation, Psychopathological Dimensions, and Prefrontal Dysfunctions? An Integrative View

NT3/TrkC pathway modulates the expression of UCP-1 and adipocyte size in human and murine adipose tissue

NT3/TrkC Pathway Modulates the Expression of UCP-1 and Adipocyte Size in Human and Rodent Adipose Tissue

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