Adrenergic regulation of distention-induced gastrin release in humans

Peters, Michael; Walsh, John H.; Ferrari, June; Feldman, Mark

doi:10.1016/0016-5085(82)90308-0

Cited by 29 publications

(1 citation statement)

References 33 publications

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“…Other studies show that low-dose atropine depresses gastrin release in response to feeding in both intact and vagotomized dogs, suggesting that this effect is mediated by local neural reflexes (53). Because the gastrin release in response to antral distention is depressed by the β-adrenergic antagonists, an adrenergic sympathetic reflex may be involved (91). Antral distention in humans also activates inhibitory pathways of gastrin release because it inhibits GRP-stimulated release by an unknown mechanism.…”

Section: Neuralmentioning

confidence: 97%

The G Cell

Sawada

Dickinson²

1997

Annu. Rev. Physiol.

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The study of gastrin continues to serve as an excellent model for gastrointestinal regulatory processes. This review highlights some recent advances in the field by outlining gastrin biosynthesis, summarizing current understanding of gastrin receptors, describing the regulation of gastrin release, and discussing the clinical implications of gastrin in the pathogenesis of peptic ulcer disease. Emphasis is on three emerging areas of gastrin research: the novel finding that one of gastrin's posttranslational processing intermediates has biological activity distinct from that of the mature peptide; elucidation of gastrin's signal transduction mechanisms that mediate the trophic effects of the peptide; and the role of gastrin in peptic ulcer disease pathogenesis secondary to Helicobacter pylori infection.

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Section: Neuralmentioning

confidence: 97%