Adrenergic regulation of clock gene expression in mouse liver

Terazono, Hideyuki; Mutoh, Tatsushi; Yamaguchi, Shun; Kobayashi, Masaki; Akiyama, Masashi; Udo, Rhyuta; Ohdo, Shigehiro; Okamura, Hitoshi; Shibata, Shigenobu

doi:10.1073/pnas.0936797100

Cited by 265 publications

(238 citation statements)

References 47 publications

Supporting

Mentioning

218

Contrasting

Unclassified

Order By: Relevance

“…These connections provide a mechanism for the SCN to coordinate peripheral cellular oscillators to optimize responses to slower endocrine signals. Several lines of evidence support the notion that neural communication from the SCN to the periphery is responsible for the timing of clock gene expression in targets organs and glands (Guo et al, 2005;Shibata, 2004;Terazono et al, 2003).…”

Section: Clocks In the Neuroendocrine Systemmentioning

confidence: 79%

See 1 more Smart Citation

The regulation of neuroendocrine function: Timing is everything

Kriegsfeld

Silver

2006

Hormones and Behavior

129

View full text Add to dashboard Cite

Hormone secretion is highly organized temporally, achieving optimal biological functioning and health. The master clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus coordinates the timing of circadian rhythms, including daily control of hormone secretion. In the brain, the SCN drives hormone secretion. In some instances, SCN neurons make direct synaptic connections with neurosecretory neurons. In other instances, SCN signals set the phase of "clock genes" that regulate circadian function at the cellular level within neurosecretory cells. The protein products of these clock genes can also exert direct transcriptional control over neuroendocrine releasing factors. Clock genes and proteins are also expressed in peripheral endocrine organs providing additional modes of temporal control. Finally, the SCN signals endocrine glands via the autonomic nervous system, allowing for rapid regulation via multisynaptic pathways. Thus, the circadian system achieves temporal regulation of endocrine function by a combination of genetic, cellular, and neural regulatory mechanisms to ensure that each response occurs in its correct temporal niche. The availability of tools to assess the phase of molecular/cellular clocks and of powerful tract tracing methods to assess connections between "clock cells" and their targets provides an opportunity to examine circadian-controlled aspects of neurosecretion, in the search for general principles by which the endocrine system is organized. KeywordsCircadian; Diurnal; Endocrinel; Neurosecretion; Clock genes; Suprachiasmatic Circadian aspects of reproductionThe importance of circadian (about a day) timing in hormone production/secretion has been known since the 1950s when Everett and Sawyer determined that a stimulatory signal occurring during a narrow temporal window on the afternoon of proestrus is necessary for induction of ovulation later that night (Everett and Sawyer, 1950). Such close temporal organization is important for successful reproduction, as numerous hormone-dependent behavioral and physiological processes must be coordinated. If optimal temporal relationships are disrupted, pronounced deficits in fertility can result. For example, ovulation, behavioral estrus, fertilization, and pregnancy maintenance require a specific

show abstract

Section: Clocks In the Neuroendocrine Systemmentioning

confidence: 79%

“…6). A role of autonomic control in peripheral clock resetting comes from investigations in which manipulations of autonomic connections to liver reset clock gene expression in this organ (Terazono et al, 2003).…”

Section: Hormonal and Neural Communication To Glandsmentioning

confidence: 99%

The regulation of neuroendocrine function: Timing is everything

Kriegsfeld

Silver

2006

Hormones and Behavior

129

View full text Add to dashboard Cite

show abstract

“…A recent study by Cailotto et al (2009) shows by selectively removing the autonomic innervation to the liver that light input information affects gene expression in the liver via the autonomic nervous system (Cailotto et al, 2009). Comparable experiments using stimulation of the autonomous nervous system have reached a similar conclusion (Terazono et al, 2003). Regarding entrainment mechanisms by hormones, glucocorticoids play an important role.…”

Section: Synchronization Of the Liver Oscillator By Systemic Timing Cuesmentioning

confidence: 90%

The role of clock genes and rhythmicity in the liver

Schmutz

Albrecht

Ripperger

2012

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

The liver is the important organ to maintain energy homeostasis of an organism. To achieve this, many biochemical reactions run in this organ in a rhythmic fashion. An elegant way to coordinate the temporal expression of genes for metabolic enzymes relies in the link to the circadian timing system. In this fashion not only a maximum of synchronization is achieved, but also anticipation of daily recurring events is possible. Here we will focus on the input and output pathways of the hepatic circadian oscillator and discuss the recently found flexibility of its circadian transcriptional networks.

show abstract

“…It is not known whether the neural connections of the SCN with the autonomous nervous system directly regulate clock gene expression in the pancreas, liver, heart, muscle (Kalsbeek and Buijs, 2002;Terazono et al, 2003) and adipose tissue (Kalsbeek et al, 2001), or whether the regulation is effected through SCN-driven humoral signals (Balsalobre, 2002). Glucocorticoids, a SCN-driven signal, modify the phase of clock genes expression in liver, pancreas, kidney and heart in animals subjected to restricted feeding conditions (Balsalobre et al, 2000) and in rat-1 fibroblasts (Balsalobre et al, 2000;Le Minh et al, 2001;Balsalobre, 2002).…”

Section: Peripheral Clocks Are Responsible For Overt Circadian Rhythmsmentioning

confidence: 99%

“…An analogous innervation pathway connecting the SCN with the adrenal cortex has been described (Buijs et al, 1999). It has been proposed that the connections between the SCN and the autonomous nervous system underlie the signaling of circadian information to the pancreas, liver, heart and even to muscle (Kalsbeek and Buijs, 2002;Terazono et al, 2003) and adipose tissue (Kalsbeek et al, 2001). The importance of the neural pathway between the SCN and the peripheral tissues for the regulation of circadian rhythms has been demonstrated in animals in which lesion of the SCN is followed by SCN grafting.…”

Section: Suprachiasmatic Nucleus Output Pathwaysmentioning

confidence: 99%

The Circadian Timing System: Making Sense of day/night gene expression

et al. 2004

View full text Add to dashboard Cite

The circadian time-keeping system ensures predictive adaptation of individuals to the reproducible 24-h day/ night alternations of our planet by generating the 24-h (circadian) rhythms found in hormone release and cardiovascular, biophysical and behavioral functions, and others. In mammals, the master clock resides in the suprachiasmatic nucleus (SCN) of the hypothalamus. The molecular events determining the functional oscillation of the SCN neurons with a period of 24-h involve recurrent expression of several clock proteins that interact in complex transcription/translation feedback loops. In mammals, a glutamatergic monosynaptic pathway originating from the retina regulates the clock gene expression pattern in the SCN neurons, synchronizing them to the light:dark cycle. The emerging concept is that neural/humoral output signals from the SCN impinge upon peripheral clocks located in other areas of the brain, heart, lung, gastrointestinal tract, liver, kidney, fibroblasts, and most of the cell phenotypes, resulting in overt circadian rhythms in integrated physiological functions. Here we review the impact of day/night alternation on integrated physiology; the molecular mechanisms and input/output signaling pathways involved in SCN circadian function; the current concept of peripheral clocks; and the potential role of melatonin as a circadian neuroendocrine transducer.

show abstract

Adrenergic regulation of clock gene expression in mouse liver

Cited by 265 publications

References 47 publications

The regulation of neuroendocrine function: Timing is everything

The regulation of neuroendocrine function: Timing is everything

The role of clock genes and rhythmicity in the liver

The Circadian Timing System: Making Sense of day/night gene expression

Contact Info

Product

Resources

About