Adrenergic Receptor Genotype Influence on Midthigh Intermuscular Fat Response to Strength Training in Middle-Aged and Older Adults

Yao, Lili; Delmonico, Mathew J.; Roth, Stephen M.; Hand, Brian D.; Johns, Joshua; Conway, Joan M.; Douglass, Larry W.; Hurley, Ben F.

doi:10.1093/gerona/62.6.658

Cited by 16 publications

(16 citation statements)

References 34 publications

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“…Our findings on the interaction between the ADRA2B D/ I polymorphism and physical activity are in line with the results of two recently published studies [22,23]. In an elegant experiment, 98 relatively healthy, sedentary white and African-American men and women participated in a strength-training programme [22].…”

Section: Discussionsupporting

confidence: 91%

“…Intermuscular fat with strength training decreased in the ADRA2B D allele carriers but slightly increased in II homozygotes. The change of intermuscular fat with strength training was statistically significant (P ¼ 0.04) between the ADRA2B D allele carriers and II homozygotes [22]. In a recent report of the Finnish Diabetes Prevention Study of multiple lifestyle intervention [23], leisure time physical activity interacted with the ADRA2B D/I polymorphism to influence the prevalence of diabetes mellitus.…”

Section: Discussionmentioning

confidence: 95%

“…In an elegant experiment, 98 relatively healthy, sedentary white and African-American men and women participated in a strength-training programme [22]. Intermuscular fat with strength training decreased in the ADRA2B D allele carriers but slightly increased in II homozygotes.…”

Section: Discussionmentioning

confidence: 99%

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Anthropometric and metabolic phenotypes in relation to the ADRA2B deletion/insertion polymorphism in Chinese population

Wen

et al. 2008

Journal of Hypertension

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 95%

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Anthropometric and metabolic phenotypes in relation to the ADRA2B deletion/insertion polymorphism in Chinese population

Wen

et al. 2008

Journal of Hypertension

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“…A single, 10 mm, axial computed tomography (CT) scan of the right and left mid-thigh was obtained (GE Lightspeed pro16; General Electric, Waukesha, WI) at 120 kVp with the scanning time set for 1 s at 100 mA while the subject lay supine (Yao et al 2007). Due to equipment availability, seven subjects were scanned on a diVerent scanner (GE CTI Single Slice, General Electric, Waukesha, WI), but scans on all subjects were performed on the same scanner for baseline and follow-up.…”

Section: Mid-thigh Compositionmentioning

confidence: 99%

Effect of moderate intensity resistance training during weight loss on body composition and physical performance in overweight older adults

et al. 2010

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The impact of resistance training has not been thoroughly examined in overweight older adults undergoing weight loss. Subjects (n = 27) were overweight and obese (BMI 31.7 +/- 3.6 kg/m(2)) older (age 67 +/- 4 years) adults and were randomized into either a 10-week Dietary Approaches to Stop Hypertension for weight loss diet (DASH, n = 12) or DASH plus moderate intensity resistance training (DASH-RT, n = 15). Outcomes included weight loss, total body and mid-thigh composition, muscle and physical function. There were no significant weight loss differences between the DASH-RT and DASH groups (-3.6 +/- 0.8 vs. -2.0 +/- 0.9%, p = 0.137). The DASH-RT group had a greater reduction in body fat than the DASH group (-4.1 +/- 0.9 vs. -0.2 +/- 1.0 kg, p = 0.005). The DASH-RT group had greater changes in lean mass (+0.8 +/- 0.4 vs. -1.4 +/- 0.4 kg, p = 0.002) and strength (+60 +/- 18 vs. -5 +/- 9 N, p = 0.008) than the DASH group. There were favorable changes in mid-thigh composition variables in the DASH-RT group that were different than the lack of changes observed in the DASH group, except for intermuscular adipose tissue. Both groups experienced decreases in 400-m walk times showed (DASH -36 +/- 11 s, DASH-RT -40 +/- 7 s) with no differences between groups. Moderate intensity resistance training during weight loss appears to improve fat mass and thigh composition, but weight loss only does not. However, global measures of physical functioning may improve with a weight loss-only program.

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“…total body fat, abdominal fat, lean soft tissue), measured by dual energy X-ray absorptiometry, may be significantly altered by resistance training in post-menopausal women (Teixeira et al 2003) and, although limited, there is evidence suggesting that adrenergic receptor variants may influence this body composition response to resistance training (Yao et al 2007), as well as aerobic training (Phares et al 2004). These observations positioned the BEST Study to begin to address recent recommendations by leading scientists recently convened by the National Cancer Institute for the Gene-Nutrition and Gene-Physical Activity Interactions in the Etiology of Obesity Workshop which called for precision measurements of phenotype and candidate gene testing within a well-controlled intervention (Bouchard and Agurs-Collins 2008).…”

Section: Introductionmentioning

confidence: 99%

Lifestyle Modifies the Relationship Between Body Composition and Adrenergic Receptor Genetic Polymorphisms, ADRB2, ADRB3 and ADRA2B: A Secondary Analysis of a Randomized Controlled Trial of Physical Activity Among Postmenopausal Women

et al. 2010

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Genetic variations in the adrenergic receptor (ADR) have been associated with body composition in cross-sectional studies. Recent findings suggest that ADR variants may also modify body composition response to lifestyle. We assessed the role of ADR variants in body composition response to 12 months of resistance training versus control in previously sedentary postmenopausal women. Randomized trial completers were genotyped for A2BGlu9/12 by fragment length analysis, and B2Gln27Glu and B3Trp64Arg by TaqMan (n=148, 54% hormone therapy users). Associations between genotypes and body composition, by dual energy X-ray absorptiometry, were analyzed using univariate models. There was no main effect of individual genes on change in body composition, however, gene × exercise interactions were observed for A2BGlu9/12 and B2Gln27Glu on change in lean soft tissue (LST, p=0.02); exercisers on the A2BGlu9- background gained LST compared to a loss among controls over 12 months (p<0.05), with no significant intervention effect on the A2B Glu9+ background. Similarly, there was a significant LST gain with exercise on the B2Glu27+ background compared to loss among controls and no intervention effect on the B2Glu27- background. A non-significant association between total body fat (TBF) and B3Trp64Arg persisted among sedentary controls only when intervention groups were separated (%TBF gain with B3Arg 64+ carriage, p=0.03); exercisers lost TBF regardless of genotype. In summary, effect modification by lifestyle was demonstrated on ADR A2B, B2, and B3 genetic backgrounds. Individuals with certain ADR genotypes may be more vulnerable to adverse changes in body composition with sedentary behavior, thus these candidate genes warrant further study.

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Adrenergic Receptor Genotype Influence on Midthigh Intermuscular Fat Response to Strength Training in Middle-Aged and Older Adults

Abstract: ADR genotype influences IMF response to strength training.

Cited by 16 publications

References 34 publications

Anthropometric and metabolic phenotypes in relation to the ADRA2B deletion/insertion polymorphism in Chinese population

Anthropometric and metabolic phenotypes in relation to the ADRA2B deletion/insertion polymorphism in Chinese population

Effect of moderate intensity resistance training during weight loss on body composition and physical performance in overweight older adults

Lifestyle Modifies the Relationship Between Body Composition and Adrenergic Receptor Genetic Polymorphisms, ADRB2, ADRB3 and ADRA2B: A Secondary Analysis of a Randomized Controlled Trial of Physical Activity Among Postmenopausal Women

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