Adrenergic mechanisms in the canine ureter

Abstract

The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

Actions of Some Autonomic Drugs on Spontaneous Contractions of Isolated Dog Ureter

“…This will be supported by the following observations: (a) a pure a-adrenoceptor stimulant (phenylephrine) [4] produced only increases in both frequency and tension of the spontaneous contrac tions, which were suppressed by phentolamine, and (b) a p-adrenoceptor stimulant (isoproterenol) could induce a disappearance of spontaneous contractions, which was prevented by prior administration of propranolol. Thus, through the present study, the existence and possible functions of a-and P-adrenoceptors in the dog ureteral smooth muscles were demonstrated and this agrees in part with some previous observations [6,8,16].…”

Effect of aminoglycoside antibiotics on the electrical stimulation-induced contractile response of the guinea-pig ureter.

“…Significant concentrations of catecholamines in a dog ureter have been demonstrated by a fluorometric assay (Boyarsky et al, 1966). The evidence is apparently in support of the presence of alpha-and beta-adrenergic receptors in the ureters of a canin, rabbit and guineapig (McLeod et al, 1973;Shuba, 1981;Weiss et al, 1978). As already mentioned, however, the intramural nerves of the ureter did not affect ureteral contractility.…”

“…There have been numerous reports supporting either a myogenic or neurogenic basis for the movement of ureteral smooth muscle in mammalia (Boyarsky et al, 1966;DualteEscalante et al, 1969;Kaplan et al, 1968;Lapides, 1948;McLeod et al, 1973;Melick et al, 1961;O'Conor and Dawson-Edwards, 1959;Shulman, 1974Shulman, , 1981Wein et al, 1972aWein et al, , 1972bWeiss et al, 1978). The question of whether the ureter is innervated or not is still controversial.…”

The Effect of Glucagon and Diazoxide on the Normal and Obstructed Upper Urinary Tract

“…Adrenergic agents have been shown to af fect the ureter under various experimental conditions [1][2][3], but there is little evidence that the sympathetic system influences nor mal baseline ureteral function. Pharmacolog ical treatment of the ureter with adrenergic agents and their blockers have not been re warding because their actions are short-lived and are often associated with severe cardio vascular side effects.…”