Adrenergic effects on the biology of the adult mammalian cardiocyte.

Dl, Mann; Kent, RL; Parsons, B. J.; th, Cooper G

doi:10.1161/01.cir.85.2.790

Cited by 777 publications

(424 citation statements)

References 50 publications

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“…Myocyte loss can occur via toxic mechanisms, producing necrosis, or by programmed cell death, producing apoptosis (9). There is experimental evidence that myonecrosis might be triggered by elevated levels of circulating or tissue norepinephrine, or by excessive stimulation with angiotensin II or endothelin (25,26). It has been proved in in vitro and in vivo models that apoptosis can be triggered by multiple factors taking part in the pathogenesis of heart failure, such as myocardial stretch, norepinephrine, TNF, oxidative stress, angiotensin II.…”

Section: Changes At the Myocyte And Myocardium Levelmentioning

confidence: 99%

Prediction of Short-Term Outcomes in Patients With Idiopathic Dilated Cardiomyopathy Referred for Transplantation Using Standard Echocardiography and Strain Imaging

Jasaitytė

Dandel

Lehmkuhl

et al. 2009

Transplantation Proceedings

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Section: Changes At the Myocyte And Myocardium Levelmentioning

confidence: 99%

Prediction of Short-Term Outcomes in Patients With Idiopathic Dilated Cardiomyopathy Referred for Transplantation Using Standard Echocardiography and Strain Imaging

Jasaitytė

Dandel

Lehmkuhl

et al. 2009

Transplantation Proceedings

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“…Amphetamine has been shown to induce apoptosis in fetal rat neocortical neurons (Stumm et al, 1999) and in PC12 cells (Oliveira et al, 2002) in a process generally considered to be associated with increased stress and formation of reactive oxygen substances. Moreover, the ephedrine-related catecholamine, norepinephrine, induces apoptosis in cardiac myocytes (Singh et al, 2001) by binding to b-adrenergic receptors through a mechanism that is dependent on activation of cyclic AMP-dependent protein kinase (Mann et al, 1992;Communal et al, 2000).…”

Section: Hl-60mentioning

confidence: 99%

Khat (Catha edulis)-induced apoptosis is inhibited by antagonists of caspase-1 and -8 in human leukaemia cells

et al. 2004

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Khat chewing is a widespread habit that has a deep-rooted sociocultural tradition in Africa and the Middle East. The biological effects of khat are inadequately investigated and controversial. For the first time, we show that an organic extract of khat induces a selective type of cell death having all morphological and biochemical features of apoptotic cell death. Khat extract was shown to contain the major alkaloid compounds cathinone and cathine. The compounds alone and in combination also induced apoptosis. Khat-induced apoptosis occurred synchronously in various human cell lines (HL-60, NB4, Jurkat) within 8 h of exposure. It was partially reversed after removal of khat and the effect was dependent on de novo protein synthesis, as demonstrated by cotreatment with cycloheximide. The cell death was blocked by the pan-caspase inhibitor Z-VAD-fmk, and also by submicromolar concentrations of Z-YVAD-fmk and Z-IETD-fmk, inhibitors of caspase-1 and -8, respectively. The 50% inhibition constant (IC 50 ) for khat (200 mg ml À1 )-induced apoptosis by Z-VAD-fmk, Z-YVAD-fmk and Z-IETD-fmk was 8 Â 10 À7 M as compared to 2 Â 10 À8 M and 8 Â 10 À8 M, respectively. Western blot analysis showed a specific cleavage of procaspase-3 in apoptotic cells, which was inhibited by Z-VAD-fmk. The cell death by khat was more sensitively induced in leukaemia cell lines than in human peripheral blood leukocytes. It is concluded that khat induces a rather swift and sensitive cell death by apoptosis through mechanisms involving activation of caspase-1, -3 and -8.

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“…α-Adrenergic receptor mediated effects and consequences of increased norepinephrine concentrations have proven to be vicious effects of increased sympathetic tone. 15,17 It was demonstrated that carvedilol, a combined α-and β-adrenergic receptor blocker had superior hemodynamic and metabolic effects compared to single β1-receptor blockade in conscious dogs with dilated cardiomyopathy and clear sympathoexcitation. 18 These results were in accordance with those obtained in the carvedilol or metoprolol european trial (COMET) trial, which compared carvedilol and metoprolol.…”

Section: Discussionmentioning

confidence: 99%

Improving Myocardial Perfusion by Percutaneous Coronary Intervention Reduces Central Sympathetic Activity in Stable Angina

Gomes¹,

Aengevaeren²,

Lenders³

et al. 2010

Clinical Cardiology

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BackgroundBy stimulating sympathetic afferents, repetitive myocardial ischemia induces a state of increased sympathetic tone.HypothesisRemoving the ischemic trigger by revascularization using percutaneous coronary intervention (PCI) might thus reduce central sympathetic activity in symptomatically stable angina patients.MethodsA total of 20 patients with stable angina ≥ New York Heart Association (NYHA) class II with persistent symptoms despite maximal pharmacological therapy and a clinical indication for PCI, were included in our study. Sympathetic nervous system activity was measured before and 1 month after PCI by a combination of techniques: direct muscle sympathetic nerve activity (MSNA), neurochemical (plasma catecholamine levels), and heart rate variability (HRV).ResultsAll patients completed the study. After PCI there was a significant reduction in MSNA (pre‐PCI 72 ± 4 to post‐PCI 53 ± 4 burst/100 beats, P < .05) and low frequency/high frequency (LF/HF) ratio (3.7 ± 0.6 vs 2.4 ± 0.4, P < .05) consistent with a decline in sympathetic activity. Plasma norepinephrine levels were reduced after PCI, but this difference did not reach statistical significance (1.84 ± 0.17 vs 1.73 ± 0.13 nmol/L, P = not significant).ConclusionCoronary revascularization by PCI reduces sympathetic activity in patients with established myocardial ischemia. Copyright © 2010 Wiley Periodicals, Inc.

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Adrenergic effects on the biology of the adult mammalian cardiocyte.

Abstract: Background. To

Cited by 777 publications

References 50 publications

Prediction of Short-Term Outcomes in Patients With Idiopathic Dilated Cardiomyopathy Referred for Transplantation Using Standard Echocardiography and Strain Imaging

Prediction of Short-Term Outcomes in Patients With Idiopathic Dilated Cardiomyopathy Referred for Transplantation Using Standard Echocardiography and Strain Imaging

Khat (Catha edulis)-induced apoptosis is inhibited by antagonists of caspase-1 and -8 in human leukaemia cells

Improving Myocardial Perfusion by Percutaneous Coronary Intervention Reduces Central Sympathetic Activity in Stable Angina

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