Adrenergic Blockade in Hypertension

Lewis, Paul; George, C. F.; Dollery, C. T.

doi:10.1016/s0140-6736(72)90948-8

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…It has earlier been reported by Lewis, George & Dollery (1973) that the one limiting side-effect of indoramin was sedation. In the present study the addition of a diuretic allowed a lower dose of indoramin to be used while still giving effective control of the blood pressure.…”

Section: Discussionmentioning

confidence: 94%

Open Assessment of the Long‐term Efficacy and Tolerance of Indoramin in Hypertension

Shah

1981

Brit J Clinical Pharma

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1 The long-term efficacy and tolerance of indoramin, a competitive post-synaptic ca.adrenoceptor antagonist, was assessed in 41 hypertensive outpatients whose blood pressures were not controlled by hydrochlorothiazide. 2 Thirty-three patients completed at least 12 months treatment with indoramin plus diuretic. Both erect and supine diastolic blood pressure was significantly reduced after 1, 3, 6, 9 and 12 months' treatment compared with pretreatment values. 3 Heart rate did not change nor was there any evidence of rebound hypertension when indoramin was abruptly withdrawn in 13 patients. 4 No patient was withdrawn because of side-effects. The commonest side-effects were sedation (four patients) and intermittent failure of ejaculation (three patients). These effects were either tolerated with continued treatment or disappeared with a modest reduction in dose. 5 It is concluded that indoramin is an effective hypotensive agent and does not possess the disadvantages of reflex tachycardia, postural hypotension, tolerance and gastrointestinal symptoms associated with earlier a-adrenoceptor antagonists.

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Section: Discussionmentioning

confidence: 94%

Open Assessment of the Long‐term Efficacy and Tolerance of Indoramin in Hypertension

Shah

1981

Brit J Clinical Pharma

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“…The antihypertensive action of indoramin has been demonstrated in several open studies (Carballo, Conde, Lapelle & Suarez, 1974;Faerchtein et al, 1976;Kramer, Rosendorff & Bloom, 1974), and confirmed in comparative double-blind studies against placebo (Lewis, George & Dollery, 1973;Klahr etal., 1976;Ramirez, 1976). Indoramin was used as a sole agent in the treatment of hypertension in all these studies.…”

Section: Introductionmentioning

confidence: 81%

Long‐term Efficacy of Indoramin in Hypertension

Yajnik

Patel

1981

Brit J Clinical Pharma

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Twenty‐five hypertensive patients were treated in an open trial with indoramin and hydrochlorothiazide for periods up to 43 months (mean 13 months). The average standing blood pressure decreased from 180/115 mm Hg to 148/94 mm Hg. Sixteen (64%) patients maintained satisfactory response with a mean daily dose of 101.5 mg of indoramin. Postural hypotension, reflex tachycardia or weight gain were not found in any patient. Eight patients (32%) taking high doses experienced troublesome giddiness, drowsiness and depression necessitating withdrawal of the drug. No electrocardiographic or biochemical adverse effects were noted. Normotension was prolonged in three patients when the drug was abruptly withdrawn.

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“…a -Blocking drugs Phenoxybenzamine given alone and in combination leads to appreciable fluid retention with weight gain averaging between 1.25 and 2.8 kg (Beilin & Juel-Jensen, 1972). Indoramin also promotes retention of salt and water to a comparable degree (Lewis, George & Dollery, 1972). Stimulation of the adrenergic nerve supply to the rat kidney has been shown to decrease urinary sodium excretion without change in renal blood flow or glomerular filtration rate, by a direct effect on proximal tubular reabsorption (Bello-Reuss et al, 1976), but whether a-or Por dopaminergic-receptors are involved in this response is not clear.…”

Section: P-a Drenergic Blocking Drugsmentioning

confidence: 99%

Implications of Antihypertensive Therapy on Sodium Balance and Sodium and Water Retention

Ledingham

1981

Brit J Clinical Pharma

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Adrenergic Blockade in Hypertension

Cited by 3 publications

References 5 publications

Open Assessment of the Long‐term Efficacy and Tolerance of Indoramin in Hypertension

Open Assessment of the Long‐term Efficacy and Tolerance of Indoramin in Hypertension

Long‐term Efficacy of Indoramin in Hypertension

Implications of Antihypertensive Therapy on Sodium Balance and Sodium and Water Retention

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