Adrenergic and Serotoninergic Control of Growth Hormone Secretion in Adult Male Rats1

Collu, R.; Fraschini, F.; Visconti, Pablo E.; Martini, L.

doi:10.1210/endo-90-5-1231

Cited by 152 publications

(58 citation statements)

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“…In rats, the administration of dopaminergic agents exert the inhibitory action on the release of growth hormone (GH) (Collu et al, 1972 ;Kato et al, 1974), though contradicting data were reported by Smythe et al (1975). At any rate, dopaminergic agents appear to exert their effects acting through the hypothalamus (Collu et al, 1972;Kato et al, 1974).…”

Section: Discussionmentioning

confidence: 89%

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Stimulation of immunoreactive somatostatin release from hypothalamic synaptosomes by high (K+) and dopamine.

et al. 1977

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SynopsisEffects of high (K+) and dopamine on the release of immunoreactive somatostatin from isolated hypothalamic synaptosomes were studied in rats. High (K+)(60 mM) and dopamine (10-s M) in the incubation media stimulated the release of immunoreactive somatostatin and the former effect was completely abolished by the removal of Ca++ from the media. These suggest that hypothalamic somatostatinergic synaptosomes preserved at least one of the important basic properties of secretory cells. Although it is of interest to note that dopamine stimulated the release of somatostatin. Its physiological significance awaits further studies.

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Section: Discussionmentioning

confidence: 89%

“…At any rate, dopaminergic agents appear to exert their effects acting through the hypothalamus (Collu et al, 1972;Kato et al, 1974). However, it is largely unknown how somatostatin is involved in the mechanism whereby dopamine modulates the secretion of GH in rats.…”

Section: Discussionmentioning

confidence: 99%

Stimulation of immunoreactive somatostatin release from hypothalamic synaptosomes by high (K+) and dopamine.

et al. 1977

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“…Accumulating evidence in recent years suggests that serotoninergic mechanisms are implicated in the regulation of both growth hormone (GH)1 and ACTH in laboratory animals (1)(2)(3)(4)(5). In our previous studies we observed that oral administration of 5-hydroxytryptophan, a precursor of serotonin, caused an increase in ment of plasma GH and cortisol.…”

Section: Introductionmentioning

confidence: 87%

Suppression by cyproheptadine of human growth hormone and cortisol secretion during sleep.

Chihara¹,

Kato²,

Maeda³

et al. 1976

J. Clin. Invest.

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“…Imura, Nakai, and Yoshimi (4) recently demonstrated that hGH secretion is stimulated by relatively small doses of the serotonin (5-hydroxytryptamine)' precursor 5-hydroxytryptophan (5-HTP), and, furthermore, on the basis of studies on patients with excess serotonin secretion (carcinoid syndrome), Feldman and Lebovitz (5) have suggested that serotonin may be a stimulator of hGH release. Collu, Fraschini, Visconti, and Martini (6) have demonstrated that intraventricular administration of serotonin causes GH release in the rat. Our studies (7)(8)(9) have shown that rat GH secretion is stimulated by intraperitoneal administration of 5-HTP and, furthermore, that it is inhibited by serotoninergic blockade and also by the pineal gland hormone, melatonin, which appears to act by competing with ser-otonin for serotonin receptor sites (9).…”

Section: Introductionmentioning

confidence: 99%

Suppression of Human Growth Hormone Secretion by Melatonin and Cyproheptadine

Smythe¹,

Lazarus²

1974

J. Clin. Invest.

138

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A B S T R A C T Pituitary growth hormone (GH) release in the rat is stimulated via serotoninergic pathways and can be inhibited by treatment with compounds that act as serotonin antagonists, such as cyproheptadine or the pineal gland hormone, melatonin. To investigate a possible role for serotonin in the control of human GH release, the effects of cyproheptadine and melatonin administration on the GH responses of normal. male subjects were examined.The oral administration of cyproheptadine (8-12 mg daily for 5 days) to normal subjects reduced their GH responses to both insulin-induced hypoglycemia and physical exercise to a highly significant extent. Similarly, the mean GH responses of 10 subjects to insulin-induced hypoglycemia were significantly reduced after the prior oral administration of melatonin (1 g).The data presented show that serotonin antagonism has a similar effect on GH secretion in man to that observed in the rat and provides further evidence for serotoninergic, and possibly pineal, involvement in the control of human GH secretion.

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Adrenergic and Serotoninergic Control of Growth Hormone Secretion in Adult Male Rats1

Cited by 152 publications

References 0 publications

Stimulation of immunoreactive somatostatin release from hypothalamic synaptosomes by high (K+) and dopamine.

Stimulation of immunoreactive somatostatin release from hypothalamic synaptosomes by high (K+) and dopamine.

Suppression by cyproheptadine of human growth hormone and cortisol secretion during sleep.

Suppression of Human Growth Hormone Secretion by Melatonin and Cyproheptadine

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