Adrenalinsekretion und Adrenalinverarmung der Kaninchennebennieren nach Reserpin

Kroneberg, G.; Schümann, H. J.

doi:10.1007/bf00247145

Cited by 32 publications

(9 citation statements)

References 9 publications

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“…Evidence that normal synthesis of catechol amines in the adrenal gland is limited by slow conversion of tyrosine to DOPA has been presented by Udenfriend & Wyngaarden (1956). Our suggestion, that the loss of amine stores and of nerve function is finally due to the normal rate of synthesis being inadequate to compensate for a small 'leak' of transmitter due to reserpine, receives support from investigations on the output of catechols from rabbit adrenals (Kroneberg & Schumann, 1958). If the depletion of transmitter were due solely to its liberation, then one might expect removal of this stored product to result in an acceleration of its synthesis.…”

Section: Reserpine On Intestinal Sympathetic Nerves 31mentioning

confidence: 72%

“…The output of amine after reserpine should show a large initial increase due to the liberation of the stores; following exhaustion of these stores, the output should fall but remain at a level higher than normal because of the postulated acceleration in syiithesis. In fact the output of adrenaline in the adrenal venous blood is raised only during the first few hours following reserpine administration (Kroneberg & Schumann, 1958).…”

Section: Reserpine On Intestinal Sympathetic Nerves 31mentioning

confidence: 99%

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The inhibitory action of the sympathetic nerves on the smooth muscle of the rabbit gut, its reversal by reserpine and restoration by catechol amines and by DOPA

Gillespie¹,

Mackenna²

1961

The Journal of Physiology

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In a previous investigation (Gillespie & Mackenna, 1960) rabbits were given daily intravenous injections of reserpine for several days and the responses of an innervated preparation of the colon from these animals were studied in vitro, the entire parasympathetic and sympathetic outflows being available for separate stimulation. It was expected that reserpine, which is believed to deplete adrenergic nerve endings of their chemical transmitter sympathin, would abolish the inhibitory effect of sympathetic nerve stimulation; in fact, inhibition was consistently replaced by a large contraction. This finding was the starting point of the investigations reported in this paper. In addition it has been found that in preparations from reserpine-treated rabbits the inhibitory effect of sympathetic nerve stimulation can be restored by soaking in adrenaline or noradrenaline; the mechanism of this restoration has been studied. A preliminary account of these results has already been published (Gillespie & Mackenna, 1959). METHODSRabbits of either sex were killed by a blow on the neck and bled. Two types of innervated intestinal preparations were used. First, the doubly innervated preparation of the rabbit colon in which the extrinsic sympathetic (lumbar colonic) and parasympathetic (pelvic) nerves can be separately stimulated, by means of fluid electrodes. The dissection of this preparation and the details of the electrodes have been described (Garry & Gillespie, 1955). The second type of preparation consisted of a length of about 4 cm of mid ileum together with the mesentery and mesenteric artery supplying the region. The artery, plus some adjacent mesentery, was drawn into a fluid electrode and the periarterial nerves were stimulated. The preparations were suspended in a 200 ml. bath filled with Krebs's saline solution at 360 C and oxygenated by a gas mixture of 95% 02 and 5 % CO2. The composition of the saline solution was (g/l.) NaCl 6-92, KCI 0.35, CaCl2 0-28, KH2PO4 0-16, NaHCO3 21, MgSO4. 7H20 0-29, glucose 2-0. The contractions of the preparations were recorded with a light isotonic gimbal lever exerting a tension of 0*5 g and writing sideways on a smoked drum. The nerves were stimulated with 1 msec rectangular pulses whose voltage was adjusted to give maximal responses. The duration of stimulation was usually 15 sec and the frequency 10/sec for the pelvic nerve and 50/sec for the lumbar colonic nerves. Where other frequencies or durations of stimulation were used this is indicated. 2PHYSIO. CLVI

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Section: Reserpine On Intestinal Sympathetic Nerves 31mentioning

confidence: 72%

Section: Reserpine On Intestinal Sympathetic Nerves 31mentioning

confidence: 99%

The inhibitory action of the sympathetic nerves on the smooth muscle of the rabbit gut, its reversal by reserpine and restoration by catechol amines and by DOPA

Gillespie¹,

Mackenna²

1961

The Journal of Physiology

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“…Reserpine releases norepinephrine from heart and blood vessels (3,7,10,26). Furthermore, concentrations of catechol amines in heart and adrenals are higher in the presence of iproniazid followed by reserpine than after reserpine alone (10,23).…”

Section: ) In Intact Ratsmentioning

confidence: 97%

“…On the other hand, the decrease of the hy pertensive response to reserpine in adrenalectomized and iproni azid treated animals suggests that epinephrine and norepinephrine might play a role. The catecholamines released from brain (31,32), adrenals (9,15,23) and other tissues (22) (particularly heart and bloodvessels) (3,7,10,26) by reserpine could exert more ac tivity because they are not metabolized through monoamineoxidase at their sites of release.…”

mentioning

confidence: 99%

The Pressor Effect of Reserpine after Monoamine-oxidase Inhibitors

Garattini¹,

Fresia²,

Mortari³

et al. 1960

Pharmacology

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“…Iproniazid 1 hemmt diese W irkung von Reserpin 2 (3,9,11,15). Diese Abschwächung der Reserpinw irkung kann durch gleichzeitige Gabe von Chlorprom azin 3 4 so aufgehoben werden, daß die Reserpinw irkung wieder hervortritl (5).…”

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Einfluß von Pharmaka auf die Histochemie des Nebennierenmarkes der Ratte

Studer¹

1961

Pathobiology

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Adrenalinsekretion und Adrenalinverarmung der Kaninchennebennieren nach Reserpin

Cited by 32 publications

References 9 publications

The inhibitory action of the sympathetic nerves on the smooth muscle of the rabbit gut, its reversal by reserpine and restoration by catechol amines and by DOPA

The inhibitory action of the sympathetic nerves on the smooth muscle of the rabbit gut, its reversal by reserpine and restoration by catechol amines and by DOPA

The Pressor Effect of Reserpine after Monoamine-oxidase Inhibitors

Einfluß von Pharmaka auf die Histochemie des Nebennierenmarkes der Ratte

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