Adrenal-sparing surgery for phaeochromocytoma

Neumann, Hartmut P. H.; Bender, Bernhard U.; Reincke, Martín; Eggstein, S.; Laubenberger, Jörg; Kirste, Günter

doi:10.1046/j.1365-2168.1999.00974.x

Cited by 109 publications

(66 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The advantages of the minimal invasive techniques are shorter hospital stay and recovery time, decreased requirements Endocrine-Related Cancer (2007) 14 935-956 www.endocrinology-journals.org for analgesics, a cosmetically better result, and patient satisfaction. In cases of bilateral sporadic or hereditary PHEO, adrenal sparing surgery preserving adrenocortical function should be favored (Neumann et al 1999).…”

Section: Managementmentioning

confidence: 99%

Pheochromocytoma: an update on genetics and management

Karagiannis¹,

Mikhailidis²,

Athyros³

et al. 2007

Endocrine Related Cancer

116

View full text Add to dashboard Cite

Pheochromocytomas (PHEOs) are rare neoplasms that produce catecholamines and usually arise from the adrenal medulla and are considered to be an adrenal paraganglioma (PGL). Closely related tumors of extraadrenal sympathetic and parasympathetic paraganglia are classified as extraadrenal PGLs. Most PHEOs are sporadic, but a significant percentage (w25%) may be found in patients with germline mutations of genes predisposing to the development of von Hippel-Lindau disease, neurofibromatosis 1, multiple endocrine neoplasia type 1 (MEN1) and 2 (MEN2), and the PGL/PHEOs syndrome, based on the described mutations of the genes for succinate dehydrogenase subunit D (SDHD), B (SDHB), and C (SDHC). As one out of four PHEOs turns out to be a hereditary clinical entity, screening for genetic alterations is important, as it provides useful information for a rational diagnostic approach and management. This review discusses the genetics, the pathophysiology of hypertension, the clinical picture, the biochemical and imaging diagnosis, and the preferred therapeutic approach for PGLs/PHEOs. Furthermore, it emphasizes the need for genetic testing in cases with apparently sporadic PHEOs.

show abstract

Section: Managementmentioning

confidence: 99%

Pheochromocytoma: an update on genetics and management

Karagiannis¹,

Mikhailidis²,

Athyros³

et al. 2007

Endocrine Related Cancer

116

View full text Add to dashboard Cite

show abstract

“…Hereditary pheochromocytoma syndromes were diagnosed clinically and/or by molecular genetic methods: VHL by the search of retinal angiomas or hemangioblastomas in the patient or a first-degree relative and the detection of germline mutations in the VHL gene [8]. VHL should be considered in the differential diagnosis of paraganglioma [2].…”

Section: Discussionmentioning

confidence: 99%

Pheochromocytoma and Multifocal Functioning Paraganglioma in a 9-Year-Old Boy with von Hippel-Lindau Disease

Tröbs

Reichardt

Friedrich³

et al. 2002

Urol Int

View full text Add to dashboard Cite

We report the case of a 9-year-old boy presenting with multifocal paraganglioma partially involving the right suprarenal gland, abdominal paraganglia, and the left para-aortal retropleural region. Von Hippel-Lindau disease (VHL) was diagnosed exclusively by VHL-gene analysis. Other clinical signs of VHL were lacking. After a complaint-free period of 7 months the boy developed a metachronous paraganglioma adjacent to the opposite adrenal gland. Patients with VHL disease should undergo adrenal-sparing surgery.

show abstract

“…lifelong steroid replacement for postoperative Addison's disease, could be avoided. Since 1985, all my patients have been operated on accordingly, in the first few years by Helmut Kirste in an open procedure (Neumann et al 1999). The extended concept was Endoscopic Adrenal Sparing Surgery.…”

Section: The Fight For Adrenal-sparing and Endoscopic Surgery In Herementioning

confidence: 99%