Adrenal solitary fibrous tumor: A case report

Yonli, Diataga Sylvestre; Chakroun, Marouene; Mokadem, Seif; Saadi, Ahmed; Rammeh, Soumaya; Chébil, Mohamed

doi:10.1016/j.eucr.2019.100919

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…In the adrenal gland, a primary occurrence of solitary fibrous tumor had only been documented eleven times in the English literature [10][11][12][13][14][15][16][17][18][19][20] (Table 1).…”

Section: Discusionmentioning

confidence: 99%

“…In the last decade, these types of tumors have been characterized as asymptomatic tumors [6]. In both the Yonly [13] and Kuribayashi [11] cases when the patient's tumor reached size of 10cm, pain symptoms were reported and the patients decided to undergo surgery. This clearly shows that tumor related pain symptoms are the main reason for deciding to undergo surgery in this case.…”

Section: Discusionmentioning

confidence: 99%

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Solitary Fibrous Tumor of Adrenal Gland and Review of the Literature

Ambardjieva

Saidi

Jovanović

et al. 2021

Prilozi

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Solitary fibrous tumor (SFT) is a rare and still controversial entity. This type of tumor first appeared in the literature as a pleural lesion, but, over the last decades, it has been reported in many extrathoracic sites. As a tumor of the adrenal gland, SFT is still rare and very uncommon, thus extensive research among the English language literature has been performed. We present here a case report of an adrenal SFT which is compared to 11 other known cases. Our case report is from a patient with SFT on the left adrenal gland, followed by mild symptoms of abdominal discomfort and hypertension. Physical examination, laboratory, and radiological tests were performed. The patient underwent surgery and the material was sent for histopathologic analysis for a definite diagnosis. Regular follow up appointments were performed over the course of two years. No recurrence of the tumor has been detected. We explain the symptoms, diagnosis, treatment, and additionally we describe the results and implications of the findings reported in the literature. Correct diagnosis is mandatory for optimal management of solitary fibrous tumor patients.

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Section: Discusionmentioning

confidence: 99%

Section: Discusionmentioning

confidence: 99%

Solitary Fibrous Tumor of Adrenal Gland and Review of the Literature

Ambardjieva

Saidi

Jovanović

et al. 2021

Prilozi

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“…These tumors were first described as being within the pleura, but it was later observed that it can also have an extra pleural localisation. There were also cases described of fibrous solitary tumors in various locations: liver, pelvis, peritoneum, meningeal, adrenal gland, intrapulmonary, urinary bladder, pericardium, and almost every organ system [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…PSFTs are found within the pleura in 57.7% of cases, with the rest (42.3%) being localized extrapleural [8,10]. The World Health Organization (2015) reviewed the classification of pleural tumors from a pathological view and placed them in three categories: mesothelial tumors, mesenchymal tumors, and lympho-proliferative disorder.…”

Section: Introductionmentioning

confidence: 99%

Pleural Solitary Fibrous Tumors—A Retrospective Study on 45 Patients

et al. 2020

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Introduction: The purpose of this paper is to study the type, the clinical presentation, and the best diagnostic methods for pleural solitary fibrous tumors (PSFTs), as well as to evaluate which is the most appropriate treatment, especially as PSFTs represent a rare occurrence in the thoracic pathology. Material and Method: A retrospective study was conducted on a group of 45 patients submitted to surgery between January 2015 and December 2019. In most cases, the diagnosis was established through imaging studies—thoracic computed tomography (CT) scan with or without contrast—but also using magnetic resonance imaging (MRI) or positron emission tomography (PET) scans when data from CT scans were scarce. All patients were submitted to surgery with curative intent. Results: Most patients included in this study were asymptomatic, with this pathology being more common in patients over 60 years of age, and more common in women. The occurrence of malignant PSFT in our study was 17.77% (8 cases). All cases were submitted to surgery with curative intent, with a single case developing further recurrence. In order to achieve complete resection en bloc resection of the tumor with the chest wall, resection was performed in two cases, while lower lobectomy, pneumectomy, and hemidiaphragm resection, respectively, were needed in each case. Postoperative mortality was null. Conclusion: Thoracic CT scan remains the most important imagistic investigation in diagnosing. MRI is superior to thoracic CT, especially in cases that involved the larger blood vessels within the thorax, spinal column, or diaphragm. Complete surgical resection is the gold standard in treatment of PSFT, and the prognosis in benign cases is very good.

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Solitary Fibrous Tumor of the Adrenal Gland

Jha¹,

Mohanty

Sampat³

et al. 2022

American Journal of Clinical Pathology

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Objectives Solitary fibrous tumor (SFT) is a mesenchymal neoplasm that can arise at various anatomic locations. It is characterized by inv12(q13q13)-derived NAB2::STAT6 fusion, resulting in the nuclear expression of STAT6. Primary SFT of the adrenal gland is rare. We launched a multi-institutional collaboration to comprehend the overarching demographics, clinical and follow-up, macroscopic, microscopic, IHC, and FISH features of 9 patients with SFT of the adrenal gland. Methods We added a series of 9 patients to the collection of adrenal SFTs where the clinicopathologic parameters, including clinical presentation, imaging, histopathology, IHC, molecular profiles, and management and follow-up data, were analyzed comprehensively. A modified 4-variable risk stratification model, including age, tumor size, and necrosis, was applied. Results Our series consisted of 6 male and 3 female patients, ranging in age from 19 to 64 years (mean, 49.3 years). Abdominal pain (4) and fever with abdominal pain (1) were the presenting symptoms in 5 patients. In the remaining 4 patients, the tumors were detected by abdominal imaging for hypertension and diabetes. The size of the tumor ranged from 2 cm to 10.5 cm in maximum dimension. All tumors exhibited the morphology of a spindle cell SFT with a patternless architecture; 3 had a focal storiform arrangement. STAT6 positivity was observed in all tumors, and 7 were positive for CD34. Surgical resection was the primary modality of treatment. No adjuvant therapy was administered. Follow-up ranging from 7 months to 23 months was available for 7 patients. All were alive without disease recurrence or metastasis. Risk stratification placed 8 (88.9%) patients into a low-risk category and 1 into an intermediate-risk category. Conclusions This series is the largest of adrenal SFTs to date. These tumors of the adrenal gland are predominantly spindle cell neoplasms with indolent behavior, with a wide age distribution and a slight male preponderance. Combining our cohort with the previously published cases, the majority of tumors fall into the low-risk category for the propensity to develop metastases. Owing to the rarity and age distribution associated with these tumors, the differential diagnosis is wide and requires a systematic approach for ruling out key differential diagnoses aided by STAT6 IHC.

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Adrenal solitary fibrous tumor: A case report

Cited by 4 publications

References 5 publications

Solitary Fibrous Tumor of Adrenal Gland and Review of the Literature

Solitary Fibrous Tumor of Adrenal Gland and Review of the Literature

Pleural Solitary Fibrous Tumors—A Retrospective Study on 45 Patients

Solitary Fibrous Tumor of the Adrenal Gland

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