Adrenal Regeneration and Adrenal-Regeneration Hypertension

Skelton, Floyd R.

doi:10.1152/physrev.1959.39.1.162

Cited by 105 publications

(35 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, it has been proposed that Snail-mediated tumour recurrence is associated with selfrenewal in cancer stem cell-like cells (De Craene and Berx, 2006). In this regard, snail expression of single cells in the zona glomerulosa of normal adrenal cortex close to the organ capsule (see Figure 3C) may indicate an adrenal stem cell, so called adrenocyte, which has been proposed by several groups (Skelton, 1959;Belloni et al, 1990;Feige et al, 1998). Thus, our study might also indicate a role of Snail expression as a prognostic marker in ACC.…”

Section: Discussionmentioning

confidence: 84%

Expression of the zinc-finger transcription factor Snail in adrenocortical carcinoma is associated with decreased survival

et al. 2008

View full text Add to dashboard Cite

In this study, we evaluate whether Snail is expressed in adrenocortical cancer (ACC) and if its expression is related to patient outcome. One of the best known functions of the zinc-finger transcription factor Snail is to induce epithelial-to-mesenchymal transition (EMT). Increasing evidence suggests that EMT plays a pivotal role in tumour progression and metastatic spread. Snail and E-cadherin expression were assessed by immunohistochemistry in 26 resected ACCs and real-time quantitative RT–PCR expression analysis was performed. Data were correlated with clinical outcome and in particular with overall patient survival. Seventeen of 26 (65%) ACC tumour samples expressed Snail when assessed by immunohistochemistry. Snail expression was neither detected in normal adrenocortical tissue, nor in benign adrenocortical adenomas. Expression levels were confirmed on the mRNA level by Real-Time–PCR. Survival rates were significantly decreased in Snail-positive tumours compared to Snail-negative tumours: 10 out of 16 vs one out of eight patients succumbed to disease after a median follow up of 14.5 and 28.5 months, respectively ( P =0.03). Patients with Snail-expressing ACCs presented in advanced disease (11 out of 12 vs 6 out of 14, P =0.01) and tend to develop distant metastases more frequently than patients with negative staining (7 out of 11 vs two out of eight, P =0.19). In conclusion, we describe for the first time that Snail is expressed in a large subset of ACCs. Furthermore, Snail expression is associated with decreased survival, advanced disease and higher risk of developing distant metastases.

show abstract

Section: Discussionmentioning

confidence: 84%

Expression of the zinc-finger transcription factor Snail in adrenocortical carcinoma is associated with decreased survival

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Adrenal regeneration hypertension (ARH) develops in saline-drinking rats following unilateral adrenal enucleation and contralateral adrenalectomy, with (Skelton, 1959) or without (Hall & Hall, 1965) unilateral nephrectomy. The development of high BP is associated with regeneration of the adrenal cortex and raised plasma steroid levels of both mineralocorticoids (e.g.…”

Section: Mean Concentrations Of 0-and S-substituted Metabolites Inmentioning

confidence: 99%

Untitled

1982

British J Pharmacology

View full text Add to dashboard Cite

“…In the innermost zone, the oldest adrenocytes acquire the reticularis phenotype, characterized in primates by the ability to synthesize adrenal androgens (dehydroepiandrosterone). Subcapsular remnants obtained after adrenal enucleation are able to regenerate differentiated cortical tissue with functional fasciculata and reticularis zones, even when grafted in ectopic locations (Skelton 1959, Belloni et al 1990). The subcapsular glomerulosa zone thus probably contains what may be considered the adrenocyte stem cells.…”

mentioning

confidence: 99%