Adrenal myelolipoma associated with adenoma

Manassero, Francesca; Pomara, Giorgio; Rappa, Francesca; Cuttano, Maria Giuseppa; Crisci, Alfonso; Selli, Cesare

doi:10.1111/j.1442-2042.2004.00793.x

Cited by 24 publications

(24 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is usually hormonally inactive, and found in 0.08 to 0.2% of autopsy series [6,7] but comprise up to 15% of adrenal incidentalomas with the increasing use of noninvasive imaging [8] and account for 2.6% of all primary adrenal tumours [9]. Myelolipomas, affect both sexes equally and usually occur during fifth and seventh decades of life [10].…”

Section: Discussionmentioning

confidence: 99%

Myelolipoma: A Rare Adrenal Incidentaloma

Tiwari¹,

Halder²

2015

Surgery

View full text Add to dashboard Cite

Case ReportOpen Access IntroductionMyelolipomas are rare, benign tumors composed of mature adipose tissue and hematopoietic elements (myeloid and erythroid cells) [1]. We describe a case of dual pathology where adrenal incidentaloma was successfully treated. Case ReportA 40-year-old lady was referred to surgical outpatient clinic with an ultrasonologically detected adrenal mass, while being investigated for menorrhagia with a large pelvic mass. She did not have any symptoms related to the adrenal mass and was normotensive. Further biochemical investigations directed to adrenal pathology revealed a normal urinary VMA level, serum electrolytes and cortisol levels. The initial ultrasound scan suggested a well-defined, hyperechoic SOL in the left suprarenal region (94 x 80 mm) suggestive of a lipomatous tumour, along with a large intrauterine fibroid (119 x 96 mm). Subsequently, CECT of the abdomen revealed a large, well defined, mildly & heterogeneously enhancing mass lesion showing attenuation value of fat, involving left adrenal gland, suggestive of myolipoma (Figures 1 and 2). The right suprarenal was normal. In view of the large size of the uterine tumour and the fact that menorrhagia was under control, she underwent left adrenalectomy only in the first sitting, through a modified chevron incision. Macroscopical cut section of the specimen showed homogenous yellow surface with reddish streaking. Histopathology of the specimen revealed features of myelolipoma. She had an uneventful recovery and doing well now at six months follow up. Discussion and ConclusionEdgar von Gierke first described this lesion in the adrenal in 1905 but it was named, "myelolipoma", by Charles Oberling [2,3]. The adrenal gland is the most common site, but myelolipomas also (rarely) occur in extra-adrenal sites (14% of myelolipomas are extraadrenal [4]) including the pelvis, mediastinum, retroperitoneum, and paravertebral region, as an isolated soft tissue mass [5].It is usually hormonally inactive, and found in 0.08 to 0.2% of autopsy series [6,7] but comprise up to 15% of adrenal incidentalomas with the increasing use of noninvasive imaging [8] and account for 2.6% of all primary adrenal tumours [9]. Myelolipomas, affect both sexes equally and usually occur during fifth and seventh decades of life [10]. Adrenal myelolipomas are in the majority of cases unilateral. However, they can also be bilateral [11]. Adrenal myelolipomas may be found coincidentally with other lesions in the adrenal glands, such as adenomas and less commonly with pheochromocytoma or metastases. These cases are described as "collision tumours" [12].Adrenal myelolipomas vary in size, from several millimetres to more than 30 cm, and usually in the range of 2-10 cm in diameter [1,13]. The term giant myelolipoma is preferred when the size exceeds 8 cm [14], as seen in our case. AbstractBackground: Myelolipoma is a rarely encountered, adrenal incidentaloma diagnosed on the basis of its radiological features.Aim: To describe a rare presentation with dual pathology.Case p...

show abstract

Section: Discussionmentioning

confidence: 99%

Myelolipoma: A Rare Adrenal Incidentaloma

Tiwari¹,

Halder²

2015

Surgery

View full text Add to dashboard Cite

show abstract

“…Quase sempre o mielolipoma de adrenal se constitui em um achado incidental de necropsia, tanto em humanos quanto em animais (LAM & LO, 2001;RÉPÁSSY et al, 2001;NAKAJO et al, 2003;MANASSERO et al, 2004 computadorizada e ressonância magnética (OTAL et al, 1999;NAKAJO et al, 2003;ELSAYES et al, 2004;PEREIRA et al, 2005). Essas técnicas também são utilizadas em clínica médica veterinária, entretanto, bem menos disponíveis em muitos locais (LATIMER & RAKICH, 1995;MYERS, 1997).…”

unclassified

“…Embora a patogênese exata do mielolipoma seja desconhecida, acredita-se que o neoplasma possa ser decorrente de metaplasia adrenocortical, embolismo de medula óssea ou desenvolvimento de remanescentes embrionários presentes no parênquima da adrenal (NEWMAN et al, 2000;RÉPÁSSY et al, 2001;MANASSERO et al, 2004).…”

unclassified

“…No entanto, há casos descritos em humanos em que o tratamento cirúrgico é recomendado pelo risco de ruptura espontânea e hemorragia (MANASSERO et al, 2004). Compressão dos órgãos adjacentes e dor abdominal também foram observadas (RÉPÁSSY et al, 2001).…”

unclassified

“…Histologicamente deve-se diferenciar mielolipoma de eritropoese extramedular (NEWMAN et al, 2000;MANASSERO et al, 2004;PEREIRA et al, 2005). O adenoma adrenocortical é parcial ou completamente encapsulado e constituído por células bem diferenciadas, semelhantes às células secretoras das zonas fasciculada e reticulada (CAPEN, 2002).…”

unclassified

See 2 more Smart Citations

Mielolipoma adrenal bilateral em um cão

2008

View full text Add to dashboard Cite

show abstract

Myelolipoma with Adrenocortical Adenoma: An unusual Combination that can Resemble Carcinoma

Al-Brahim

Sylvia

2007

Endocr Pathol

View full text Add to dashboard Cite

Myelolipoma is a benign tumor that occurs in the adrenal gland and rarely in extra-adrenal sites. Commonly, it is diagnosed as an incidental finding. However, some reports indicate synchronous occurrence with other lesions including adrenocortical carcinoma. It has very rarely been reported to occur in association with adrenocortical adenoma. In this paper, we report three cases of adrenal myelolipoma associated with adrenocortical adenoma; in all three patients, the radiological appearance resembled adrenocortical carcinoma. These cases emphasize the importance of this combination as a pitfall in the correct diagnosis and management of patients with adrenal masses.

show abstract

Adrenal myelolipoma associated with adenoma

Cited by 24 publications

References 9 publications

Myelolipoma: A Rare Adrenal Incidentaloma

Myelolipoma: A Rare Adrenal Incidentaloma

Mielolipoma adrenal bilateral em um cão

Myelolipoma with Adrenocortical Adenoma: An unusual Combination that can Resemble Carcinoma

Contact Info

Product

Resources

About