Adrenal Medullary Hormones in Water Diuresis.

Horres, Alan D.; Eversole, W. J.; Rock, Martha

doi:10.3181/00379727-75-18099

Cited by 19 publications

(7 citation statements)

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“…Glomerular filtration was measured as the inulin clearance, and renal plasma flow as the sodium p-aminohippurate clearance. 7 The renal clearances of sodium and potassium were determined simultaneously. The Table I for further information regarding these subjects.)…”

Section: Methodsmentioning

confidence: 99%

“…Associated changes in urine formation might be predicted but have not as yet been clearly defined. In animals, I-epinephrine seems to give rise to a water diuresis and augmented excretion of chloride (4)(5)(6)(7)(8), whereas in man both agents may diminish urine flow (1,2). A study of the effect of pure l-epinephrine and l-norepinephrine upon renal hemodynamics, and excretion of water and electrolytes in normal human subjects was undertaken in order to clarify this problem.…”

mentioning

confidence: 99%

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THE EFFECT OF EPINEPHRINE (USP), l-EPINEPHRINE, AND l-NOREPINEPHRINE ON GLOMERULAR FILTRATION RATE, RENAL PLASMA FLOW, AND THE URINARY EXCRETION OF SODIUM, POTASSIUM, AND WATER IN NORMAL MAN 12

Smythe¹,

Nickel²,

Bradley³

1952

J. Clin. Invest.

113

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

THE EFFECT OF EPINEPHRINE (USP), l-EPINEPHRINE, AND l-NOREPINEPHRINE ON GLOMERULAR FILTRATION RATE, RENAL PLASMA FLOW, AND THE URINARY EXCRETION OF SODIUM, POTASSIUM, AND WATER IN NORMAL MAN 12

Smythe¹,

Nickel²,

Bradley³

1952

J. Clin. Invest.

113

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“…Diuresis of water and chloride has been observed in acute experiments in animals given relatively small amounts of adrenaline (12)(13)(14)(15)(16). Although the effect of adrenaline on the renal excretion of sodium, calcium, and potassium was not studied in the animal experiments, it appears probable that the same processes were affected in those experiments as in the one reported here.…”

Section: Discussionmentioning

confidence: 42%

“…Although the diuresis observed in animal experimentation has been generally attributed to the epinephrine content of adrenaline, Horres, Eversole and Rock have recently presented evidence that it is caused by nor-epinephrine and not by epinephrine ( 16).…”

Section: Discussionmentioning

confidence: 99%

“…The changes in the urinary excretion of sodium, potassium, and chloride are opposite to those seen with increased adrenocortical activity. These changes in urinary excretion are of interest in connection with previous demonstrations in experimental animals that although adrenaline in large dosage causes oliguria, adrenaline in smaller amounts produces diuresis of water and chloride (12)(13)(14)(15)(16).…”

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confidence: 85%

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The Effect of the Chronic Administration of Adrenal Medullary Hormones to Man on Adrenocortical Function and the Renal Excretion of Electrolytes

Duncan¹,

Nichols²,

Rosenberg³

1951

J. Clin. Invest.

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The acute and chronic administration of adrenaline to experimental animals and its acute administration to man have been shown to increase adrenocortical activity.In 1908 Babes and Jonesco reported that repeated injections of adrenaline caused adrenocortical hypertrophy in rabbits (1). Vogt found by direct assay of adrenal venous blood of dogs and cats that there was an increased output of adrenocortical hormone following the injection of adrenaline (2). She subsequently reported that multiple injections of adrenaline produced adrenal hypertrophy in intact but not in hypophysectomized rats (3).Long and Fry described a decrease in adrenocortical cholesterol and ascorbic acid following the injection of adrenaline in intact but not in hypophysectomized rats (4). This and subsequent work by Gershberg and associates (5) indicate that adrenaline causes an increased output of adrenocorticotrophin. Using a decrease in the level of circulating eosinophils as a very sensitive measure of increased adrenocortical activity, Recant and colleagues showed that a single dose of adrenaline increases adrenocortical activity in the dog, rat, and man (6). Although they found eosinopenia in men receiving multiple injections of adrenaline over periods as long as 48 hours, there was no evidence of increased adrenocortical activity as measured by the urinary excretion of steroids and uric acid.However, Bliss, Rubin, and Gilbert (7) reported increases in urinary uric acid and 17-ketosteroids in normal men and women given 8 mg. of adrenaline in oil in a period of 12 hours.Guest and coworkers showed that sustained eosinopenia does not occur uniformly in patients given repeated injections of adrenaline (8).Adrenaline prepared from biological material contains about 85 per cent epinephrine and 15 per cent nor-epinephrine (9) unless a special process is included to remove nor-epinephrine. The adrenaline used in the present study was manufactured from biological material and did contain nor-epinephrine. Since nor-epinephrine produces little or no eosinopenia (10, 11), the increased adrenocortical function which follows the administration of adrenaline must be due primarily to its epinephrine content. However, some of the results reported in the present paper may well have been due to nor-epinephrine. The designation adrenaline is used in this communication to indicate a mixture of epinephrine and norepinephrine.The observations reported were undertaken to determine what manifestations of increased adrenocortical activity occur during the chronic administration of adrenaline to man. To this end the level of circulating eosinophils, the urinary excretion of uric acid, the urinary excretion of steroids, and the metabolism of nitrogen, sodium, chloride, potassium, phosphorus, and calcium have been studied in men receiving repeated injections of adrenaline over a period of days.Among the effects observed have been increased urinary excretion of sodium, chloride, calcium, and uric acid, and decreased urinary excretion of potassium. The changes in th...

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Effects of Adrenergic Activators and Inhibitors on Kidney Function

Oßwald¹,

Greven²

1981

Adrenergic Activators and Inhibitors

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Adrenal Medullary Hormones in Water Diuresis.

Cited by 19 publications

References 0 publications

THE EFFECT OF EPINEPHRINE (USP), l-EPINEPHRINE, AND l-NOREPINEPHRINE ON GLOMERULAR FILTRATION RATE, RENAL PLASMA FLOW, AND THE URINARY EXCRETION OF SODIUM, POTASSIUM, AND WATER IN NORMAL MAN 12

THE EFFECT OF EPINEPHRINE (USP), l-EPINEPHRINE, AND l-NOREPINEPHRINE ON GLOMERULAR FILTRATION RATE, RENAL PLASMA FLOW, AND THE URINARY EXCRETION OF SODIUM, POTASSIUM, AND WATER IN NORMAL MAN 12

The Effect of the Chronic Administration of Adrenal Medullary Hormones to Man on Adrenocortical Function and the Renal Excretion of Electrolytes

Effects of Adrenergic Activators and Inhibitors on Kidney Function

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