Adrenal Masses of Varied Etiology

Sharma, Punit; Singh, Harmandeep; Dhull, Varun Singh; Kc, Sudhir Suman; Kumar, Abhishek; Bal, Chandrasekhar; Kumar, Rakesh

doi:10.1097/rlu.0b013e3182a77c72

Cited by 8 publications

(7 citation statements)

References 38 publications

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“…Recently, Kumar et al reviewed the imaging characteristics of diverse adrenal gland diseases on PET/CT using different tracers. [25] 18 F-Fluorodopa PET/CT and 11 C-Hydroxyephedrine PET/CT have been used for imaging of adrenal medullary lesions, such as pheochromocytoma, and 11 C-Metomidate PET/CT has been used for adrenocortical imaging like adrenocortical carcinoma. [25] While for imaging of adrenal lymphoma, 18 F-FDG PET is very useful.…”

Section: Discussionmentioning

confidence: 99%

“…[25] 18 F-Fluorodopa PET/CT and 11 C-Hydroxyephedrine PET/CT have been used for imaging of adrenal medullary lesions, such as pheochromocytoma, and 11 C-Metomidate PET/CT has been used for adrenocortical imaging like adrenocortical carcinoma. [25] While for imaging of adrenal lymphoma, 18 F-FDG PET is very useful. [25] Apart from the demonstration of adrenal involvement, it can also show lymphomatous involvement at other sites.…”

Section: Discussionmentioning

confidence: 99%

“…[25] While for imaging of adrenal lymphoma, 18 F-FDG PET is very useful. [25] Apart from the demonstration of adrenal involvement, it can also show lymphomatous involvement at other sites. In this case, 18 F-FDG PET/CT scan revealed not only the huge bilateral well-defined adrenal masses with marked FDG uptake, but also the left thigh subcutaneous involvement.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, 18 F-FDG PET/CT plays an important role in staging, predicting disease progression and response evaluation. [25–27]…”

Section: Discussionmentioning

confidence: 99%

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Primary adrenal extranasal NK/T cell lymphoma with subcutaneous involvement demonstrated on FDG PET/CT

Dong¹,

Wang

Shen³

et al. 2019

Medicine

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Rationale:Primary adrenal non-Hodgkin lymphomas are predominant diffuse large B cell lymphoma with frequently bilateral adrenal involvement, but the occurrence of nasal type extranodal NK/T cell lymphoma is relatively rare.Patient concerns:A 40-year-old woman complaining of left back pain for 2-month was admitted to our department.Diagnosis:Based on the feature of enhanced computed tomography (CT) images which showed huge bilateral well-defined adrenal masses with heterogeneous enhancement, she was tentatively diagnosed as having primary adrenal malignancy. Postoperative pathology revealed the diagnosis of primary adrenal Epstein-Barr virus-associated nasal type extranodal NK/T-cell lymphoma.Interventions:Then, she underwent 18F-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography (PET)/CT examination for staging, which showed homogeneously increased FDG uptake in the right adrenal gland and left thigh subcutaneous lesion, as well as heterogeneous increased FDG uptake in the left adrenal gland region with no abnormal uptake in the nasal cavity. Subsequently, the patient has performed 7 cycles of gemcitabine, L-asparaginase, ifosfamide, dexamethasone, etoposide (GLIDE) regimen and autologous stem cell transplantation.Outcomes:Fortunately, the subsequent 2 follow-up FDG PET/CT scans within 1 year revealed complete resolution with no abnormal FDG uptake in the initially involved sites after 7 cycles of GLIDE chemotherapy and autologous stem cell transplantation.Lessons:The enhanced CT and FDG PET/CT features of primary adrenal extranasal NK/T cell lymphoma are huge bilateral well-defined adrenal masses with heterogeneous enhancement, high FDG uptake, especially with subcutaneous involvement. And the awareness of this entity may help clinicians to differentiate it from other primary adrenal tumors and make reasonable therapeutic strategies. Besides, FDG PET/CT scan is very useful for the treatment follow-up of the primary adrenal extranasal NK/T cell lymphoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Additionally, 18 F-FDG PET/CT plays an important role in staging, predicting disease progression and response evaluation. [25–27]…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Primary adrenal extranasal NK/T cell lymphoma with subcutaneous involvement demonstrated on FDG PET/CT

Dong¹,

Wang

Shen³

et al. 2019

Medicine

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“…8 In the evaluation of a wide spectrum of adrenal gland pathology with PET/CT performed with different radiopharmaceuticals, the most useful imaging was found to be with 18 F-FDG, although it was not found to be specific. 9 In our previous studies with 68 Ga-FAPI-04 PET/CT in different tumor types, we reported its superiority over 18 F-FDG PET/CT in staging and detection of recurrence. 10,11 In this case, we demonstrated the superiority of 18 F-FDG PET/ CT in the detection of recurrence and metastases in adrenocortical carcinoma.…”

mentioning

confidence: 93%

Superiority of 18F-FDG PET/CT to 68GA-FAPI PET/CT in Adrenocortical Tumor Imaging

et al. 2023

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18F-FDG PET/CT was performed to evaluate the response to treatment in a 62-year-old female patient who was operated for adrenocortical carcinoma. High FDG uptake was observed in recurrent lesion in the left adrenal gland site and metastatic lesions. In the 68Ga-FAPI-04 PET/CT study, low FAPI uptake was observed in both recurrences and metastases. In this case, we demonstrated the superiority of 18F-FDG PET/CT over 68Ga-FAPI-04 PET/CT in the evaluation of adrenocortical carcinoma.

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Metabolic and anatomic characteristics of benign and malignant adrenal masses on positron emission tomography/computed tomography: a review of literature

et al. 2014

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PET/CT with (18)F-fluorodeoxyglucose (FDG) or using different radiocompounds has proven accuracy for detection of adrenal metastases in patients undergoing cancer staging. It can assist the diagnostic work-up in oncology patients by identifying distant metastases to the adrenal(s) and defining oligometastatic disease that may benefit from targeted intervention. In patients with incidentally discovered adrenal nodules, so-called adrenal "incidentaloma" FDG PET/CT is emerging as a useful test to distinguish benign from malignant etiology. Current published evidence suggests a role for FDG PET/CT in assessing the malignant potential of an adrenal lesion that has been 'indeterminately' categorized with unenhanced CT, adrenal protocol contrast-enhanced CT, or chemical-shift MRI. FDG PET/CT could be used to stratify patients with higher risk of malignancy for surgical intervention, while recommending surveillance for adrenal masses with low malignant potential. There are caveats for interpretation of the metabolic activity of an adrenal nodule on PET/CT that may lead to false-positive and false-negative interpretation. Adrenal lesions represent a wide spectrum of etiologies, and the typical appearances on PET/CT are still being described, therefore our goal was to summarize the current diagnostic strategies for evaluation of adrenal lesions and present metabolic and anatomic appearances of common and uncommon adrenal lesions. In spite of the emerging role of PET/CT to differentiate benign from malignant adrenal mass, especially in difficult cases, it should be emphasized that PET/CT is not needed for most patients and that many diagnostic problems can be resolved by CT and/or MR imaging.

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Adrenal Masses of Varied Etiology

Cited by 8 publications

References 38 publications

Primary adrenal extranasal NK/T cell lymphoma with subcutaneous involvement demonstrated on FDG PET/CT

Primary adrenal extranasal NK/T cell lymphoma with subcutaneous involvement demonstrated on FDG PET/CT

Superiority of 18F-FDG PET/CT to 68GA-FAPI PET/CT in Adrenocortical Tumor Imaging

Metabolic and anatomic characteristics of benign and malignant adrenal masses on positron emission tomography/computed tomography: a review of literature

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