Adrenal insufficiency secondary to carcinoma metastatic to the adrenal gland

Sheeler, Leslie R.; Myers, James H.; Eversman, John J.; Taylor, Harris C.

doi:10.1002/1097-0142(19831001)52:7<1312::aid-cncr2820520730>3.0.co;2-o

Cited by 33 publications

(6 citation statements)

References 9 publications

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“…First, there is a broad spectrum of malignant tumours and metastases which can infiltrate the adrenal glands and the oesophagus. Although infiltration of the adrenal glands is not uncommon for some tumours, about 90% of adrenal tissue has to be destroyed to result in clinical overt insufficiency, which is rarely the case (Sheeler et al, 1983). In our patient however, no malignant tumour was found and the uneventful follow-up also argues strongly against a neoplastic disease.…”

Section: Discussionmentioning

confidence: 43%

Megaoesophagus in a patient with autoimmune polyglandular syndrome Type II

Fritzen

Bornstein

Scherbaum

1996

Clinical Endocrinology

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Dysphagia and vomiting are frequently present in untreated Addison's disease. These non-specific symptoms may be due either to the metabolic disorder and myopathy or to disorders associated with Addison's disease. We describe a patient with autoimmune adrenal failure as a feature of autoimmune polyglandular syndrome (APS) type II. This patient was referred initially because of megaoesophagus. The association of megaoesophagus with Addison's disease or any of the three types of APS has not previously been described in humans. The association of megaoesophagus and adrenal failure, however, is known to occur in Allgrove's syndrome, a disease with primary manifestation in childhood characterized by adrenal failure, achalasia and alacrimia. Moreover, there are several reports on the association of megaoesophagus with adrenocortical insufficiency and other autoimmune endocrine diseases in dogs. Vomiting and dysphagia usually resolve with hormone substitution in patients with isolated Addison's disease. In our patient these symptoms disappeared in spite of the radiological persistence of megaoesophagus, which might have been overlooked if the diagnosis of Addison's disease had been made earlier. The occurrence of megaoesophagus might be more common than previously suspected and we suggest a systematic search for similar findings in other patients with autoimmune Addison's disease, even when minor dysphagia is present.

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Section: Discussionmentioning

confidence: 43%

Megaoesophagus in a patient with autoimmune polyglandular syndrome Type II

Fritzen

Bornstein

Scherbaum

1996

Clinical Endocrinology

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“…It plays a significant role in distinguishing between adenoma, carcinoma, and metastasis in cases of "adrenal incidentaloma". On the other hand, it allows for identification of the functional nature of the adrenal mass when an adrenal incidentaloma is found [18,19] . The emergence of PET-CT for detection and surveillance has allowed for more accurate specifics of adrenal metastases, with better characterizations of the metabolic activities.…”

Section: Discussionmentioning

confidence: 99%

Case of metachronous bilateral isolated adrenal metastasis from colorectal adenocarcinoma and review of the literature

Liu

Chen

Zhai

et al. 2016

WJG

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Rarely has a solitary, metachronous bilateral adrenal metastasis of colorectal cancer been reported. We depict a 41-year-old man who underwent sigmoid colon cancer radical surgery followed by adjuvant chemotherapy for a locally ulcerative sigmoid adenocarcinoma with metachronous bilateral adrenal metastasis revealed by a computed tomography scan. Histopathological examination showed adenocarcinoma, compatible with metastasis from the rectal cancer. The level of serum carcinoembryonic antigen had indicative significance for the presence of adrenal metastasis in the reported series. We performed a literature analysis related to this pathological characteristic and attach importance to consistent, vigilant radiological surveillance of the adrenal glands in the patients' follow up for colorectal cancer with or without subsequent adrenal metastasis.

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“…Needless to say, it is essential to examine whether the adrenal mass is functional or nonfunctional when an adrenal incidentaloma is found. 23,24 Moreover, Candel et al 18 also emphasized that fine-needle aspiration biopsy of adrenal masses was helpful for making an accurate diagnosis. Although this procedure was not performed preoperatively in our patient, it is considered effective for the differential diagnosis of adrenal masses.…”

Section: Discussionmentioning

confidence: 99%

Adrenal Metastasis from Rectal Cancer: Report of a Case

et al. 2003

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We report a case of heterochronic adrenal metastasis from colorectal carcinoma in a 51-year-old woman. A left adrenal metastasis was found by computed tomography and magnetic resonance imaging 8 months after an anterior resection for advanced rectal carcinoma, and a left hepatectomy for a solitary liver metastasis. The level of serum carcinoembryonic antigen was still within the normal range. A left adrenalectomy was performed, and histopathological examination revealed adenocarcinoma, compatible with the rectal carcinoma resected 8 months earlier. The patient died of lung metastases 6 months after the adrenalectomy. A review of autopsy series in the world literature revealed that adrenal metastasis from colorectal cancer is not rare. Therefore, the possibility of adrenal metastasis should be considered in the follow-up of patients after primary surgery for colorectal cancer, even though the liver and lung are the main metastatic sites.

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Adrenal insufficiency secondary to carcinoma metastatic to the adrenal gland

Cited by 33 publications

References 9 publications

Megaoesophagus in a patient with autoimmune polyglandular syndrome Type II

Megaoesophagus in a patient with autoimmune polyglandular syndrome Type II

Case of metachronous bilateral isolated adrenal metastasis from colorectal adenocarcinoma and review of the literature

Adrenal Metastasis from Rectal Cancer: Report of a Case

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