Adrenal Ganglioneuroblastoma in an Adult: A Rare Case Report

Heidari, Zahra; Kaykhaei, Mahmoud Ali; Jahantigh, Mehdi; Sheikhi, Vahid

doi:10.5812/ijem.63055

Cited by 10 publications

(8 citation statements)

References 22 publications

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“…Here, we present the clinical course of mediastinal GNB discovered in a 17‐year‐old male adolescent. As GNBs occur almost exclusively in the pediatric population, adult onset GNB is uncommon and the mediastinum as the primary site is a further rare clinical manifestation . These points are noteworthy in the present case.…”

Section: Discussionmentioning

confidence: 55%

“…In addition, the most common sites of origin are the adrenal medulla (about 35%), extraadrenal retroperitoneum (30%–35%), and posterior mediastinum (20%) . Although cases of adolescent or adult onset GNB have been reported in the literature, they are extremely rare . With regard to mediastinal GNBs, less than 50 cases of adolescent or adult mediastinal GNB have been reported to date .…”

Section: Introductionmentioning

confidence: 99%

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Posterior mediastinal ganglioneuroblastoma in an adolescent: A case report and review

et al. 2019

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Ganglioneuroblastoma is an uncommon malignant tumor of the sympathetic nervous system, which is considered a disease of children with the majority of cases in patients less than four years old and it rarely occurs in adults. We encountered a very unusual case of a posterior mediastinal ganglioneuroblastoma that developed in a 17-year-old male adolescent who underwent successful excision of the mediastinal mass and remained stable postoperatively. However, he developed lumbago one year after the surgery. Radiographic findings revealed osteolytic lesions in the lumbar vertebra and histological analysis confirmed bone metastasis of ganglioneuroblastoma. Here, we report the clinical course and present a review of the literature regarding adolescent and adult onset mediastinal ganglioneuroblastoma.

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Posterior mediastinal ganglioneuroblastoma in an adolescent: A case report and review

et al. 2019

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“…The preoperative suspicion is difficult, and the definitive diagnosis is often made by the pathologist after surgical excision (18). Thus far, 19 adrenal GNBs have been reported in the literature in the adult age group (20), and this number will be 20 in our case. There is no specific presentation; there may be symptoms such as pain due to abdominal mass compression.…”

Section: Discussionmentioning

confidence: 77%

Rare Atypical Adrenal Pathologies: Single-center Experience

Çetin¹,

Yalcin²,

Inan³

et al. 2023

uob

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Objective: To share the clinical, radiological and biochemical features of rare atypical pathologies in our adrenalectomy series. Materials and Methods: Patients with atypical adrenal pathology among patients who underwent open or laparoscopic adrenalectomy for various indications were retrospectively reviewed. the hormonal behavior, radiological and pathological features of rare atypical adrenal pathologies in our series are demonstrated. Information about the postoperative follow-up and surveillance of the patients is given. Results: Rare adrenal pathologies were detected in 17 (11.6%) of 146 patients who underwent adrenalectomy. Adrenal cysts (6), cavernous hemangioma (3), ganglioneuroblastoma (1), ganglioneuroma (2), ectopic thyroid tissue (1), schwannoma (1), arteriovenous malformation (1), sarcomatoid carcinoma (1), and primary adrenal lenfoma (1) were the rare atypical adrenal pathologies in our series. Conclusion:Although there are no specific laboratory or radiological findings for most atypical adrenal pathologies, it should be kept in mind that such pathologies with a benign course can also be encountered by the clinician.

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“…Less than five cases per million children are reported to occur annually 5 . Most of the children affected are below 5 years of age, with the disease being slightly more common in boys than in girls 1 .…”

Section: Discussionmentioning

confidence: 99%

“…Subsets of patients with peripheral neuroblastic tumors are being identified more frequently based on spontaneous regression or differentiation and excellent overall outcomes, such as those with low‐ and intermediate‐risk NB and favorable clinical and biological characteristics (e.g., infants with small perinatal adrenal masses or those with favorable histology and absence of segmental aberrations). It is recommended to perform routine surveillance with chest X‐rays and MRI scans for mediastinal tumors for at least 2 years, as well as ultrasound or MRI scans for abdominal or paraspinal tumors 5,9,12–14 …”

Section: Discussionmentioning

confidence: 99%

A needle in the haystack: An unusual case presentation of ganglioneuroblastoma at a tertiary care center in Coastal Karnataka

Radhakrishnan,

Rao,

Lashkari

et al. 2023

Clinical Case Reports

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Key Clinical MessageThis case report highlights the importance of recognizing and accurately diagnosing ganglioneuroblastoma, an uncommon variant of neuroblastic tumors in children. Ganglioneuroblastomas have diverse clinical and morphological presentations, and histopathological examination is paramount in guiding treatment decisions, especially in cases with ambiguous symptoms. Early detection is crucial, as the prognosis varies significantly based on the subtype and the presence of metastatic disease. Clinicians should maintain a high index of suspicion and utilize radiological examinations to promptly identify and treat these tumors.AbstractChildren are frequently affected by neuroblastic tumors, which grow from the sympathoadrenal lineage of the neural crest during its development. However, intermixed ganglioneuroblastomas are far less common within the same tumor spectrum, the diagnosis of which could become challenging amidst an unusual presentation. In our case report, we present a 4‐year‐old boy who had complaints of fever and difficulty in walking, with a supra‐renal mass on ultrasound, which was diagnosed as ganglioneuroblastoma‐intermixed type on histopathological examination. This report aims to contribute to the understanding of the diverse clinical and morphological spectrum of ganglioneuroblastomas and the importance of multidisciplinary collaboration and histopathological examination to enhance decision‐making in such ambiguous scenarios.

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Adrenal Ganglioneuroblastoma in an Adult: A Rare Case Report

Cited by 10 publications

References 22 publications

Posterior mediastinal ganglioneuroblastoma in an adolescent: A case report and review

Posterior mediastinal ganglioneuroblastoma in an adolescent: A case report and review

Rare Atypical Adrenal Pathologies: Single-center Experience

A needle in the haystack: An unusual case presentation of ganglioneuroblastoma at a tertiary care center in Coastal Karnataka

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