Adrenal Cortical Function in Children on Steroids

Kuzemko, J A; Lines, John G.

doi:10.1136/adc.45.240.215

Cited by 7 publications

(6 citation statements)

References 23 publications

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“…The object of the present work was to investigate whether suppression of adrenal function occurred to the same extent in asthmatic children receiving Received 28 January 1971. prednisolone once every 48 hours, as was found in our earlier studies (Kuzemko and Lines, 1970) on similar children treated daily with this steroid. Indeed, 4 of the children reported here had been investigated earlier and were changed from a daily to an alternate-day regimen.…”

supporting

confidence: 70%

“…The findings show that there is a direct correlabefore and after (I-24 tetracosactrin are given in tion between the dose of corticosteroid and depres- t See Kuzemko and Lines (1970).…”

Section: The Results Of the Plasma Cortisol Analysesmentioning

confidence: 93%

“…Prednisolone and prednisolone stearoylglycolate dosages varied between 2-5 mg and 10 mg prednisolone or 6-65 mg and 13-3 mg prednisolone stearoylglycolate administered as a single dose every 48 hours (6-65 mg prednisolone stearoylglycolate is equivalent to 3-5 mg of prednisolone-manufacturer's data). Tetracosactrin tests and the method of cortisol measurement were performed as previously described (Kuzemko and Lines, 1970). The tests were done on the day when the child was not taking any corticosteroids or having tetracosactrin depot injection.…”

Section: Methodsmentioning

confidence: 99%

“…The response to tetrathe dosage of corticosteroid had been altered. cosactrin was classified as being normal, abnormal, or as a partial response according to the criteria Results previously advocated (Kuzemko and Lines, 1970).…”

Section: Methodsmentioning

confidence: 99%

“…The depression of adrenal cortical function by exogenous steroid therapy has been recognized in adults for many years (Shuster and Williams, 1961;Treadwell et al, 1963), and more recently adrenocortical suppression has been demonstrated in children receiving prednisolone in doses as low as 5 mg daily (Kuzemko and Lines, 1970). There have been suggestions that, as the therapeutic action of the steroid persists for more than one day, intermittent rather than daily administration of the corticosteroid might reduce the side effects of the hormonal treatment without affecting the degree of therapeutic action, and of the various regimens tried the administration of the steroid as a single dose once every 48 hours appeared to be the most efficacious (Harter, Reddy, and Thorn, 1963).…”

mentioning

confidence: 99%

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Adrenal Cortical Function in Asthmatic Children on Alternate Day Steroids

Kuzemko¹,

Lines²

1971

Archives of Disease in Childhood

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Kuzemko, J. A., and Lines, J. G. (1971). Archives of Disease in Childhood, 46, 366. Adrenal cortical function in asthmatic children on alternate-day steroids. Adrenal cortical function was determined in 16 children receiving prednisolone or prednisolone stearoylglycolate on alternate days. The dosages of the corticosteroids varied from 2-5 to 10 mg prednisolone, or 6 65 to 13-30 mg of its stearoylglycolate ester; the duration of therapy ranged from 2 to 26 months. Adrenocortical function was assessed from the plasma cortisol response to a single injection of l1-24 tetracosactrin (Synacthen); repeat tests were performed after altering steroid dosages or for reassessment of individual patients. The effects of prednisolone stearoylglycolate are compared with those of prednisolone, and the effects of alternate-day prednisolone therapy are compared with those found when this corticosteroid was given daily to similar (in three cases, the same) children.

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supporting

confidence: 70%

“…The findings show that there is a direct correlabefore and after (I-24 tetracosactrin are given in tion between the dose of corticosteroid and depres- t See Kuzemko and Lines (1970).…”

Section: The Results Of the Plasma Cortisol Analysesmentioning

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Adrenal Cortical Function in Asthmatic Children on Alternate Day Steroids

Kuzemko¹,

Lines²

1971

Archives of Disease in Childhood

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Klinisches Bild der nichtatopischen Atemwegsobstruktion

Ulmer¹

1979

Bronchitis · Asthma Emphysem

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Adrenocortical response to adrenocorticotropic hormone in relation to duration of topical therapy and percutaneous absorption of hydrocortisone in children with dermatitis

Turpeinen

1989

Eur J Pediatr

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To evaluate the effect of topical hydrocortisone therapy on cortisol secretion, the plasma cortisol response to a 2 h adrenocorticotropic hormone (ACTH) test was determined in 17 children with dermatitis. Percutaneous absorption of hydrocortisone was measured in the acute phase of dermatitis by a 4 h absorption test. Two-hour plasma cortisol in the ACTH test correlated inversely with the increment of plasma cortisol in the absorption test. The duration of topical hydrocortisone therapy had no significant influence on the adrenocortical response to ACTH. A moderately or severely subnormal 2 h plasma cortisol level was observed in three infants after 3-5 months' topical therapy with hydrocortisone.

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Adrenal Cortical Function in Children on Steroids

Cited by 7 publications

References 23 publications

Adrenal Cortical Function in Asthmatic Children on Alternate Day Steroids

Adrenal Cortical Function in Asthmatic Children on Alternate Day Steroids

Klinisches Bild der nichtatopischen Atemwegsobstruktion

Adrenocortical response to adrenocorticotropic hormone in relation to duration of topical therapy and percutaneous absorption of hydrocortisone in children with dermatitis

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