Adrenal Catecholamine Levels and Synthesizing Enzyme Activities in Newborn Swine Exposed to Cold and 6-hydroxydopamine

Epinephrine-Induced Hyperglycemia and Glycogenolysis in Fed and Fasted Neonatal Swine

“…The neonate is faced with many acute stresses during its transition from a sheltered intrauterine to a harsh extra-uterine environment, and these stresses undoubtedly activate the adrenal medulla. Direct evidence of this activation, however, is lacking for the pig, but we have shown that urinary catecholamines are increased in newborn swine exposed to 5°C for 6 h [24], Furthermore, repeated handling of newborn swine enhanced tyrosine hydroxylase activity in the adrenal glands [25].…”

“…However, these responses were more sustained in the newborn. Dawkins [6] found that epinephrine (25 ¡xg/kg i.v.) induced a smaller and more delayed rise in the blood sugar of fetal and newborn lambs than in animals 2 days of age or older.…”