ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer
Paloma Moreno,
Yuuki Ohara,
Amanda J Craig
et al.
Abstract:Pancreatic ductal adenocarcinoma (PDAC) manifests diverse molecular subtypes, including the classical/progenitor and basal-like/squamous subtypes, with the latter known for its aggressiveness. We employed integrative transcriptome and metabolome analyses to identify potential genes contributing to the molecular subtype differentiation and its metabolic features. Transcriptome analysis in PDAC patient cohorts revealed downregulation of adrenoceptor alpha 2A (ADRA2A) in the basal-like/squamous subtype, suggestin… Show more
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