ADP-dependent platelet activation is required for thrombus formation during a long-distance flight
Julie Tourn,
Estelle Carminita,
Lydie Crescence
et al.
Abstract:The association between venous thromboembolism (VTE) and air travel is well documented.Prolonged exposure to reduced atmospheric pressure and low oxygen levels during flights triggers coagulation disorders, representing the primary risk factor for Deep Vein Thrombosis (DVT), surpassing immobility. In our study, we investigated how long-distance flight conditions affect VTE development in mice exposed to 6h of hypobaric hypoxia or normobaric normoxia after inferior vena cava (IVC) ligation. We observed a pro-th… Show more
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