Adoptive transfusion of tolerant dendritic cells prolong the survival of renal allografts: a systematic review

Xia, Meng Juan; Shan, Juan; Li, You Ping; Zhou, Yan; Guo, Ying; Sun, Gui Xiang; Wu, Wen; Li, Feng

doi:10.1111/jebm.12070

Cited by 10 publications

(11 citation statements)

References 25 publications

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“…Inhibition of T effector cells and induction of regulatory T cells were observed in volunteers treated with DCs (98,99). These effects may be augmented by immunosuppressive therapies (100).…”

Section: Therapeutic Manipulation Of Renal Dcs and Macrophages Adoptimentioning

confidence: 94%

Dendritic Cells and Macrophages

Weisheit¹,

Engel

Kurts

2015

Clinical Journal of the American Society of Nephrology

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The mononuclear phagocytes (dendritic cells and macrophages) are closely related immune cells with central roles in anti-infectious defense and maintenance of organ integrity. The canonical function of dendritic cells is the activation of T cells, whereas macrophages remove apoptotic cells and microbes by phagocytosis. In the kidney, these cell types form an intricate system of mononuclear phagocytes that surveys against injury and infection and contributes to organ homeostasis and tissue repair but may also promote progression of CKD. This review summarizes the general functions and classification of dendritic cells and macrophages in the immune system and recapitulates why overlapping definitions and historically separate research have created controversy about their tasks. Their roles in acute kidney disease, CKD, and renal transplantation are described, and therapeutic strategy to modify these cells for therapeutic purposes is discussed.

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Section: Therapeutic Manipulation Of Renal Dcs and Macrophages Adoptimentioning

confidence: 94%

Dendritic Cells and Macrophages

Weisheit¹,

Engel

Kurts

2015

Clinical Journal of the American Society of Nephrology

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“…The moDCs is a wellcharacterized model of DC differentiation and huge number of works published is related to this population [8,16]. It has also been used as therapeutic strategy in cancer for cell therapy [17] and in graft tolerance [18]. The plasmacytoid DCs are not easily derived from CD34 + progenitors but they could be purified from a PBMC fraction after an enrichment using a Percoll ® gradient [19].…”

Section: Discussionmentioning

confidence: 99%

Differentiation of human dendritic cell subsets for immune tolerance induction

Deluce-Kakwata-Nkor

Lamendour

Chabot

et al. 2018

Transfusion Clinique et Biologique

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To cite this version:N. Deluce-Kakwata-Nkor, L. Lamendour, V. Chabot, A. Héraud, Z. Ivanovic, et al.. Differentiation of human dendritic cell subsets for immune tolerance induction. Transfusion Clinique et Biologique, Elsevier, 2018, 25 (1), pp.90-95. 10.1016/j.tracli.2017 Please cite this article in press as: Deluce-Kakwata-nkor N, et al. AbstractObjectives. -Since no further progress was achieved, in order to improve the long-term organ transplantation outcome, the immune tolerance appears as an interesting therapeutic goal. Dendritic cells (DCs) are specialized cells participating in the homeostasis of the immune response. Moreover, subsets of DCs, identified in humans, appear to have their respective competences in immune response modulation. Our objective is to purify from PBMC or to differentiate DC subsets from monocytes using several strategies and evaluate their IL10 secretion.Methods. -CD14 + cells were purified from peripheral blood mononuclear cell (PBMC) by affinity beads and cultured with cytokines up to 7 days. The pDCs were purified with anti-BDCA-2 beads from PBMC fraction enriched by Percoll ® gradient. The moDCs, pDCs and moLCs subsets were analyzed by phenotype labelling and FACS analyses and IL10 secretion measured by ELISA.Results. -The moDCs were characterized by the CD209 expression and a lower expression of CD1a markers. Expression of CD207 and CD1a markers characterized moLCs and CD123 + /BDCA-2 + pDCs. Variable IL-10 secretions were shown between the three DC subsets, both at basal and activated levels. Conclusions. -As the several DC populations studied have different capacities of IL-10 synthesis, they might play, among others, distinct roles in the induction of immune tolerance.

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“…It has now become evident that aging will not only affect innate immunity, but also equips adaptive immune components with tools of innate immune responses, potentially enabling players of adaptive immunity to act in an antigen-independent manner. DCs with their cardinal feature as antigen presenting cells are potent instigators of T cell stimulation and it is presumed that the change of the absolute numbers of DCs plays an inferior role in aging [67]. Depending on their maturity, DCs in rodents have been shown to critically impact rejection or tolerance in kidney transplantation [67,68].…”

Section: Innate Immunity In the Elderlymentioning

confidence: 99%

“…DCs with their cardinal feature as antigen presenting cells are potent instigators of T cell stimulation and it is presumed that the change of the absolute numbers of DCs plays an inferior role in aging [67]. Depending on their maturity, DCs in rodents have been shown to critically impact rejection or tolerance in kidney transplantation [67,68]. Several studies have addressed TLR expression on old DCs and neutrophilic granulocytes, and at least for TLR-4, a downmodulation over age has not been identified [69,70].…”

Section: Innate Immunity In the Elderlymentioning

confidence: 99%

Immunosenescence in renal transplantation

Seyda

Quante

Uehara

et al. 2015

Current Opinion in Organ Transplantation

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Purpose of review With global demographic changes and an overall improved healthcare, more older end-stage-renal-disease (ESRD) patients receive kidney transplants. At the same time, organs from older donors are utilized more frequently. Those developments have and will continue to impact allocation, immunosuppression and efforts improving organ quality. Recent findings Findings mainly outside the field of transplantation have provided insights into mechanisms that drive immunosenescence and immunogenicity, thus providing a rationale for an age-adapted immunosuppression and relevant clinical trials in the elderly. With fewer rejections in the elderly, alloimmune responses appear to be characterized by a decline in effectiveness and an augmented unspecific immune response. Summary Immunosenescence displays broad and ambivalent effects in elderly transplant recipients. Those changes appear to compensate a decline in allospecific effectiveness by a shift towards an augmented unspecific immune response. Immunosuppression needs to target those age-specific changes to optimize outcomes in elderly transplant recipients,

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Adoptive transfusion of tolerant dendritic cells prolong the survival of renal allografts: a systematic review

Cited by 10 publications

References 25 publications

Dendritic Cells and Macrophages

Dendritic Cells and Macrophages

Differentiation of human dendritic cell subsets for immune tolerance induction

Immunosenescence in renal transplantation

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