Adoptive Transfer of a Superantigen-Induced Hole in the Repertoire of Natural IgM-Secreting Cells

Silverman, Gregg J.

doi:10.1006/cimm.2001.1787

Cited by 13 publications

(11 citation statements)

References 12 publications

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“…B-1 cell populations bearing allotype markers were isolated from the peritoneal cavities of SpA or control-treated mice, and, after engraftment into a prepared compatible host, the composition of these peritoneal B cells and the circulating Ig responses were reevaluated. These studies demonstrated that if the donor had been exposed to SpA, the same clan V H III-associated defect in the circulating Ig and peritoneal B-1 cells was detected after engraftment (8). These findings confirmed that the persistent V H -targeted supraclonal loss does not require the influence of SpA that remains deposited in the peritoneum after the local infusion.…”

Section: Spa Exposure Creates a Long-lasting "Hole" In The B-1 Cell Rsupporting

confidence: 52%

A Model B-Cell Superantigen and the Immunobiology of B Lymphocytes

Silverman

Goodyear

2002

Clinical Immunology

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Section: Spa Exposure Creates a Long-lasting "Hole" In The B-1 Cell Rsupporting

confidence: 52%

A Model B-Cell Superantigen and the Immunobiology of B Lymphocytes

Silverman

Goodyear

2002

Clinical Immunology

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“…Although there have been conflicting reports on the superantigenic nature of these agents, a recent study has demonstrated that highly purified ETA and ETB induce selective polyclonal expansion of human T cells [46]. Studies of staphylococcal virulence factor, protein A, have suggested that this toxin directly influences the activity of a subset of B cells and leads to a T-cell-independent depletion of these cells in vivo [47,48]. Staphylococcal protein A (SPA) is known to bind preferentially to the VH3 family of Ig heavy-chain variable gene products.…”

Section: Staphylococcus Aureus-derived Enterotoxinsmentioning

confidence: 99%

Superantigens and nasal polyps

Bachert

Zele

Gevaert

et al. 2003

Curr Allergy Asthma Rep

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Nasal polyps represent an often severe T-cell-orchestrated eosinophilic upper airway disease with currently unknown pathogenesis, often associated with lower airway disease, such as asthma. Superantigens, predominantly derived from Staphylococcus aureus, are potent activators of T cells, induce the synthesis of IgE in B cells, and have direct effects on pro-inflammatory cells, such as eosinophils. IgE antibodies to S. aureus enterotoxins have been described in polyp tissue, linked to a local polyclonal IgE production and an aggravation of eosinophilic inflammation. Furthermore, such IgE antibodies have also been described in the sera of patients with asthma, and linked to severity of disease and steroid insensitivity. This review summarizes our current understanding of the possible role of S. aureus enterotoxins in chronic severe airway disease, such as nasal polyposis.

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“…Additionally, ETB was also shown to be moderately pyrogenic and enhanced susceptibility to lethal shock in rabbits. Studies of staphylococcal virulence factor, protein A, have suggested that this toxin also has superantigenic properties because it directly influences the activity of a subset of B cells, and leads to a T-cell-independent depletion of these cells in vivo [9].…”

Section: Staphylococcal Superantigensmentioning

confidence: 99%

Staphylococcus aureus superantigens and airway disease

Bachert

Gevaert²,

Cauwenberge³

2002

Curr Allergy Asthma Rep

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Twenty-five percent of the population are permanent carriers of Staphylococcus aureus, possibly producing a variety of toxins with superantigenic properties. Staphylococcal superantigens are a group of high- molecular-weight pyrogenic proteins that have in common an extremely potent stimulatory activity for T-lymphocytes, macrophages, mast cells, eosinophils, and epithelial cells. The role of staphylococcal superantigens in atopic dermatitis has recently been recognized, and new evidence suggests that similar mechanisms may also be relevant in airway disease. This circumstantial evidence is currently limited to rhinitis, sinusitis, and possibly asthma, but may, if supported, open a new understanding of pathomechanisms and therapeutic targets.

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Adoptive Transfer of a Superantigen-Induced Hole in the Repertoire of Natural IgM-Secreting Cells

Cited by 13 publications

References 12 publications

A Model B-Cell Superantigen and the Immunobiology of B Lymphocytes

A Model B-Cell Superantigen and the Immunobiology of B Lymphocytes

Superantigens and nasal polyps

Staphylococcus aureus superantigens and airway disease

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