Objective: To review, categorise, and synthesise findings from literature on health information technology (HIT) functionalities, HIT use, and the impact of HIT on hospital performance. Materials and Methods: We conducted a systematic integrative literature review based on a comprehensive database search. To organise, categorise and synthesise the existing literature, we adopted the affordance actualization theory. To align the literature with our research framework, we used four categories: 1) the functionalities of HIT and how these functionalities are measured; 2) use and immediate outcomes of HIT functionalities; 3) different performance indicators and how HIT functionalities affect them; and 4) what hospital characteristics influence the outcome of hospital performance. Results: Fifty-two studies were included. We identified four types of HIT. Only ten studies (19.2%) define the use of HIT by explicitly measuring the use rate of HIT. We identified five dimensions of hospital performance indicators. Every dimension showed mixed results; however, in general, HIT has a positive impact on mortality and patient readmissions. We found several hospital characteristics that may affect the relationship between HIT and hospital-level outcomes. Discussion: Further efforts should focus on embedded research on HIT functionalities, use and effects of HIT implementations with more performance indicators and adjusted for hospital characteristics. Conclusion: The proposed framework could help hospitals and researchers make decisions regarding the functionalities, use and effects of HIT implementation in hospitals. Given our research outcomes, we suggest future research opportunities to improve understanding of how HIT affects hospital performance.