Adolescents With Autism Spectrum Disorder and Anorexia Nervosa Comorbidity: Common Features and Treatment Possibilities With Cognitive Remediation Therapy and Oxytocin

Tololeski, Barbara Plemeniti; Grabner, Ana Suhodolčan; Kumperščak, Hojka Gregorič

doi:10.3389/fpsyt.2021.686030

Cited by 4 publications

(2 citation statements)

References 131 publications

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“…Vasopressin analogues, for example, desmopressin are often used in the treatment of nocturnal polyuria, hemophilia A, diabetes insipidus, Willebrand disease, or uremic bleeding (Fein & Herschkowitz, 2017). Oxytocin may also be helpful for selected group of patients suffering from post-traumatic stress disorder (PTSD) (Szafoni & Piegza, 2022), postpartum depression (Lindley- Baron-Cohen et al, 2022), autism spectrum disorder (ASD) (Plemeniti et al, 2021), and memory impairments (Zhao et al, 2019). Transnasally applied insulin not merely decrease blood glucose level, but it can also improve memory in healthy individuals and those suffering from Alzheimer's disease (AD) (Gaddam et al, 2021).…”

Section: Pharmacolog Ic Al Per S Pec Tive S Of Intr Ana Sal Nmur 2 Ag...mentioning

confidence: 99%

Pharmacomodulation of brain neuromedin U signaling as a potential therapeutic strategy

Pałasz

Worthington

Filipczyk

et al. 2023

J of Neuroscience Research

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Neuromedin U (NMU) belongs to a family of multifunctional neuropeptides that modulate the activity of several neural networks of the brain. Acting via metabotropic receptor NMUR2, NMU plays a role in the regulation of multiple systems, including energy homeostasis, stress responses, circadian rhythms, and endocrine signaling. The involvement of NMU signaling in the central regulation of important neurophysiological processes and its disturbances is a potential target for pharmacological modulation. Number of preclinical studies have proven that both modified NMU analogues such as PASR8‐NMU or F4R8‐NMU and designed NMUR2 agonists, for example, CPN‐116, CPN‐124 exhibit a distinct pharmacological activity especially when delivered transnasally. Their application can potentially be useful in the more convenient and safe treatment of obesity, eating disorders, Alzheimer's disease‐related memory impairment, alcohol addiction, and sleep disturbances. Accumulating findings suggest that pharmacomodulation of the central NMU signaling may be a promising strategy in the treatment of several neuropsychiatric disorders.

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Section: Pharmacolog Ic Al Per S Pec Tive S Of Intr Ana Sal Nmur 2 Ag...mentioning

confidence: 99%

Pharmacomodulation of brain neuromedin U signaling as a potential therapeutic strategy

Pałasz

Worthington

Filipczyk

et al. 2023

J of Neuroscience Research

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“…This last issue could be linked to what feminist theorists have published about the double risk that disabled or bodily-cognitive diverse women live because of the double intersection of oppressing structures: ableism and sexism (Bê, 2019). Linked to this, most autistic women live with comorbidities such as anxiety, depression, eating disorders, and gender dysphoria at higher rates than males (Plemeniti et al, 2021). For instance, taking as reference the subjective experience of Wendy Lawson (2006), autistic adult woman, she refers to these gender structures as struggles in her daily life: I don't desire make-up.…”

Section: Bioethical Perspectives For Autismmentioning

confidence: 99%

A radical embodied perspective of autism: towards ethical, and inclusive views for cognitive diversities

Alvear

Vargas

2022

Resistances

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Autism Spectrum Disorders have been defined as a group of developmental conditions that affect the capacity to interact with the physical and social environment, among others. A core feature of autism is the presence of restricted and repetitive behaviors that vary in complexity, form, and frequency throughout life history. These core features have traditionally been defined as impairments that interfere with communication competence. From an embodied approach, however, these actions could be seen as characteristic ways of interacting with the world. In this sense, we take an enactive and embodied approach to cognition in which we conceive cognitive agents as sensorimotor systems whose perception-action occurs in terms of affordances. This framework provides an integrative view of autism considering affectivity, perception, action, exploration, and interaction within a complex and dynamic dimension. Following this, we propose different applications based on embodied, intercultural, and feminist epistemologies, to understand and participate with autistic and cognitively diverse populations. The change in theoretical and methodological paradigms within embodied cognitive science towards autism and other cognitive diversities and how they engage with the world can lead to more comprehensive, integrative, and bioethical approaches.

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Cognitive Behavioral and Cognitive Remediation Strategies for Managing Co-Occurring Anorexia Nervosa and Elevated Autism Spectrum Traits

Saure¹,

Ålgars²,

Laasonen³

et al. 2022

PRBM

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Anorexia nervosa (AN) is a potentially severe eating disorder whose core characteristics include energy intake restriction leading to low body weight. Autism spectrum disorder (ASD) is a developmental disorder characterized by deficits in social interaction and communication as well as repetitive, stereotyped behavior and interests. Both high ASD traits and diagnosed ASD are overrepresented among individuals with AN, and AN and ASD appear to share certain neurocognitive features. These features are associated with the severity of eating disorder symptoms and prolongation of AN. Thus, individuals with AN and high ASD traits or ASD may benefit less from traditional treatment when compared to those with low ASD traits. No previous reviews have summarized what is known about treatment adaptations for individuals with AN and high ASD traits or ASD. The purpose of this narrative review was to investigate the feasibility of cognitive remediation therapy (CRT), cognitive remediation and emotional skill training (CREST), and cognitive behavioral therapy (CBT), and give an overview of treatment modifications for individuals with AN and co-occurring ASD or high ASD traits. We found nine studies that fulfilled our inclusion criteria. The combined results suggest that individuals with AN and high ASD traits or ASD benefit less from CRT, CREST, and CBT than those with AN and low ASD traits. However, CRT and CREST administered in individual format may be associated with improved cognitive flexibility, motivation for change, and decreased alexithymia among adults with AN and high ASD traits or ASD. Individuals with comorbid AN and ASD themselves highlight the importance of treatment adaptations that take the characteristics of ASD into account. In the future, controlled studies of the treatment strategies for individuals with AN and ASD/high ASD traits are needed in order to improve the outcome of individuals with this challenging comorbidity.

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Adolescents With Autism Spectrum Disorder and Anorexia Nervosa Comorbidity: Common Features and Treatment Possibilities With Cognitive Remediation Therapy and Oxytocin

Cited by 4 publications

References 131 publications

Pharmacomodulation of brain neuromedin U signaling as a potential therapeutic strategy

Pharmacomodulation of brain neuromedin U signaling as a potential therapeutic strategy

A radical embodied perspective of autism: towards ethical, and inclusive views for cognitive diversities

Cognitive Behavioral and Cognitive Remediation Strategies for Managing Co-Occurring Anorexia Nervosa and Elevated Autism Spectrum Traits

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