Adolescents with autism show typical fMRI repetition suppression, but atypical surprise response

Utzerath, Christian; Schmits, Iris C.; Buitelaar, Jan K.; Lange, Floris P. de

doi:10.1016/j.cortex.2018.08.019

Cited by 20 publications

(24 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Seven of the eight studies found some type of reduced habituation in the ASD group compared to the neurotypical (NT) group. This included decreased neural habituation to repeated tones [Font‐Alaminos et al, 2020; Kolesnik et al, 2019; Millin et al, 2018; Ruiz‐Martínez et al, 2020] and faces [Ewbank et al, 2017; Tam et al, 2017] but not to other images [Millin et al, 2018; Utzerath, Schmits, Buitelaar, & de Lange, 2018] as measured by EEG and fMRI. Overall, these results suggest widespread but stimulus‐specific reduction in neural habituation to repetition.…”

Section: Resultsmentioning

confidence: 99%

“…The two remaining studies in this category exposed participants repeatedly to simple associations and found notable differences in fMRI correlates of prediction errors based on such associations after they were learned. Utzerath et al [2018] found that the ASD group showed a trend toward a less suppressed visual cortex response on seeing expected task‐irrelevant pairings, indicating reduced use of task‐irrelevant predictive information. By contrast, Mosner et al [2019] found increased activity in various frontostriatal regions in the ASD group in response to task‐relevant reward prediction errors, indicating increased use of task‐relevant predictive information.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Prediction in Autism Spectrum Disorder: A Systematic Review of Empirical Evidence

et al. 2021

View full text Add to dashboard Cite

According to a recent influential proposal, several phenotypic features of autism spectrum disorder (ASD) may be accounted for by differences in predictive skills between individuals with ASD and neurotypical individuals. In this systematic review, we describe results from 47 studies that have empirically tested this hypothesis. We assess the results based on two observable aspects of prediction: learning a pairing between an antecedent and a consequence and responding to an antecedent in a predictive manner. Taken together, these studies suggest distinct differences in both predictive learning and predictive response. Studies documenting differences in learning predictive pairings indicate challenges in detecting such relationships especially when predictive features of an antecedent have low salience or consistency, and studies showing differences in habituation and perceptual adaptation suggest low‐level predictive processing differences in ASD. These challenges may account for the observed differences in the influence of predictive priors, in spontaneous predictive movement or gaze, and in social prediction. An important goal for future research will be to better define and constrain the broad domain‐general hypothesis by testing multiple types of prediction within the same individuals. Additional promising avenues include studying prediction within naturalistic contexts and assessing the effect of prediction‐based intervention on supporting functional outcomes for individuals with ASD. Lay Summary Researchers have suggested that many features of autism spectrum disorder (ASD) may be explained by differences in the prediction skills of people with ASD. We review results from 47 studies. These studies suggest that ASD may be associated with differences in the learning of predictive pairings (e.g., learning cause and effect) and in low‐level predictive processing in the brain (e.g., processing repeated sounds). These findings lay the groundwork for research that can improve our understanding of ASD and inform interventions. Autism Res 2021, 14: 604–630. © 2021 International Society for Autism Research and Wiley Periodicals LLC

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Prediction in Autism Spectrum Disorder: A Systematic Review of Empirical Evidence

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The finding that prior expectations evoke stimulus-selective signals selectively in the deep layers of visual cortex sheds light on the neural circuit by which the brain performs perceptual inference [21,24,33], that is, combines sensory signals with internal expectations to generate a best guess of what is out there in the world. Ultimately, future work building on these findings may be able to reveal how this delicate balance between internal and external signals can go awry, as it does in disorders such as autism [75][76][77] and psychosis [16,78,79].…”

Section: Discussionmentioning

confidence: 99%

Prior expectations evoke stimulus-specific activity in the deep layers of the primary visual cortex

et al. 2020

View full text Add to dashboard Cite

The way we perceive the world is strongly influenced by our expectations. In line with this, much recent research has revealed that prior expectations strongly modulate sensory processing. However, the neural circuitry through which the brain integrates external sensory inputs with internal expectation signals remains unknown. In order to understand the computational architecture of the cortex, we need to investigate the way these signals flow through the cortical layers. This is crucial because the different cortical layers have distinct intra- and interregional connectivity patterns, and therefore determining which layers are involved in a cortical computation can inform us on the sources and targets of these signals. Here, we used ultra-high field (7T) functional magnetic resonance imaging (fMRI) to reveal that prior expectations evoke stimulus-specific activity selectively in the deep layers of the primary visual cortex (V1). These findings are in line with predictive processing theories proposing that neurons in the deep cortical layers represent perceptual hypotheses and thereby shed light on the computational architecture of cortex.

show abstract

“…This may indicate that disruptions of adaptation in ASD are region-specific. Indeed, a recent investigation revealed equivalent fMRI repetition suppression in the visual system in individuals with ASD ( Utzerath et al, 2018 ). However, the contributions of different mechanisms that underlie adaptation ( Lanting et al, 2013 ) may vary by cortical region.…”

Section: Discussionmentioning

confidence: 99%

Reduced auditory cortical adaptation in autism spectrum disorder

Millin

Kolodny

Flevaris

et al. 2018

eLife

View full text Add to dashboard Cite

Adaptation is a fundamental property of cortical neurons and has been suggested to be altered in individuals with autism spectrum disorder (ASD). We used fMRI to measure adaptation induced by repeated audio-visual stimulation in early sensory cortical areas in individuals with ASD and neurotypical (NT) controls. The initial transient responses were equivalent between groups in both visual and auditory cortices and when stimulation occurred with fixed-interval and randomized-interval timing. However, in auditory but not visual cortex, the post-transient sustained response was greater in individuals with ASD than NT controls in the fixed-interval timing condition, reflecting reduced adaptation. Further, individual differences in the sustained response in auditory cortex correlated with ASD symptom severity. These findings are consistent with hypotheses that ASD is associated with increased neural responsiveness but that responsiveness differences only manifest after repeated stimulation, are specific to the temporal pattern of stimulation, and are confined to specific cortical regions.

show abstract

Adolescents with autism show typical fMRI repetition suppression, but atypical surprise response

Cited by 20 publications

References 43 publications

Prediction in Autism Spectrum Disorder: A Systematic Review of Empirical Evidence

Prediction in Autism Spectrum Disorder: A Systematic Review of Empirical Evidence

Prior expectations evoke stimulus-specific activity in the deep layers of the primary visual cortex

Reduced auditory cortical adaptation in autism spectrum disorder

Contact Info

Product

Resources

About