Adolescents after pemberton's osteotomy for developmental dysplasia of the hip displayed greater joint loading than healthy controls in affected and unaffected limbs during gait

Abstract

Cross‐sectional geometrical (CSG) properties of an Iron Age Samnite group from the Alfedena necropolis (Abruzzo, Italy, 2600–2400 B.P.) are compared with a Ligurian Neolithic sample (6000–5500 B.P.). In the period under examination, Samnites were organized in a tribal confederation led by patrilinear aristocracies, indicating incipient social stratification. In comparison, Neolithic society lacked clear signs of social hierarchy. The subsistence of both groups was mainly based on pastoralism and agriculture, but changes in habitual behavior are expected due to the socio‐economic transformations that characterized the Iron Age. The Samnites' warlike ideology suggests that unimanual weapon‐use and training would have become frequent for males. The intensification of agriculture and the adoption of transhumant pastoralism, performed by a smaller subset of the population, likely led to a lower average level of logistic mobility. The strongly genderized ideology of the period suggests a strict sexual division of labor, with women primarily performing sedentary tasks. CSG properties based on periosteal contours were calculated for humeri, femora, and tibiae (N = 61). Results corroborated the expectations: Alfedena males show substantial humeral bilateral asymmetry, indicating prevalent use of one arm, likely due to weapon training. In both sexes lower limb results indicate reduced mobility with respect to the Neolithic group. Sexual dimorphism is significant in both humeral asymmetry and lower limb indicators of mobility. Although both groups could be broadly defined as agropastoral based on archeological and historical evidence, CSG analysis confirmed important differences in habitual behavior. Am J Phys Anthropol, 2010. © 2010 Wiley‐Liss, Inc.

Residual gait deviations in adolescents treated during infancy for unilateral developmental dysplasia of the hip using Pemberton's osteotomy

“…Inverse dynamics analysis was performed to obtain the internal joint moments. Loading rates of the GRF were calculated as the maximum slopes of the vertical component curves during the initial DLS [19]. For subsequent statistical analysis, peak values, as well as values of the joint angles and moments, and pelvic angles at heel-strike, the beginning and end of SLS and toe-off, were extracted.…”

“…For subsequent statistical analysis, peak values, as well as values of the joint angles and moments, and pelvic angles at heel-strike, the beginning and end of SLS and toe-off, were extracted. Temporal-spatial parameters were also calculated, including gait speed, cadence, stride length, step length, and step width [19], which were normalized to LL. The upward acceleration of the heel marker immediately before initial contact was obtained to indicate how the swing foot was controlled for a smooth heel-strike.…”

“…with Pemberton's osteotomy during infancy showed that these patients sustained greater than normal rates of repetitive loading around heel-strike in both hips, exposing themselves to a higher risk of premature hip OA [19]. Since the loading between the foot and the ground is a result of the control of the whole body and the way it makes contact with the floor, a complete 3D gait analysis will be helpful for a better picture of the mechanisms that may be responsible for the altered loading condition [19].…”

“…Since the loading between the foot and the ground is a result of the control of the whole body and the way it makes contact with the floor, a complete 3D gait analysis will be helpful for a better picture of the mechanisms that may be responsible for the altered loading condition [19]. The purpose of this study was to evaluate the residual changes in the joint kinematics and kinetics of the locomotor system during level walking in adolescents who had received Pemberton's osteotomy for unilateral DDH at an early age.…”

Hydrogen sulfide exhibits cardioprotective effects by decreasing endoplasmic reticulum stress in a diabetic cardiomyopathy rat model

“…The second is the activation of caspase-12. It was demonstrated that pre-caspase-12 is hydrolyzed, and caspase-12 is activated during ERS (87)(88)(89)(90). Activated caspase-12 promotes apoptosis by activating caspase-9 and caspase-3 through a non-cytochrome c-dependent pathway.…”