Adolescent voluntary exercise attenuated hippocampal innate immunity responses and depressive-like behaviors following maternal separation stress in male rats

Sadeghi, Mahsa; Peeri, Maghsoud; Hosseini, Mir-Jamal

doi:10.1016/j.physbeh.2016.05.017

Cited by 65 publications

(44 citation statements)

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“…The FST was performed using methods previously described by Sadeghi, Peeri, & Hosseini, (2016). The equipment for this test consisted of a glass barrel (height = 46 cm, diameter = 20 cm) filled with 36 cm of water and maintained at 23 ± 1°C.…”

Section: Forced Swimming Testmentioning

confidence: 99%

Short‐ and long‐term antidepressant effects of ketamine in a rat chronic unpredictable stress model

et al. 2017

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Section: Forced Swimming Testmentioning

confidence: 99%

Short‐ and long‐term antidepressant effects of ketamine in a rat chronic unpredictable stress model

et al. 2017

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“…In the rodent models noted earlier, 21‐23 voluntary (ie, not forced) exercise was associated with reductions in depressive/anxious behaviors expressed following exposure to stress. In this study we used a measure of leisure and transportation time physical activity which most likely captures respondents’ participation in sport and other physical activities typically engaged in for pleasure or general enjoyment (eg, cycling to work), and not regimented or forced exercise.…”

Section: Discussionmentioning

confidence: 81%

“…In spite of the known knowledge gaps in the state of the literature, supportive evidence for the use of aerobic activity in migraine treatment is on the rise 20 . In animal models of stress and exercise, voluntary exercise has been show to reverse the stress‐induced deficits such as depressive‐like behaviors inflicted by maternal separation, 21 eliciting counteractive anti‐depressant effects comparable to positive controls administered fluoxetine (a Selective Serotonin Reuptake Inhibitor class antidepressant) 22 . Maniam and Morris 23 linked early life maternal separation to both increased depressive‐like behavior and anxiety, and found that voluntary exercise improved behavioral outcomes for male rats.…”

Section: Introductionmentioning

confidence: 99%

The Role of Positive Health Behaviors in the Relationship Between Early Life Stress and Migraine

Hammond

Colman

2020

Headache

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Background.-The use of diet and physical activity in alleviating the burden of migraine is unclear, therefore, more scientific study on the role of positive health behaviors in migraine management is needed.Objective.-To explore the potential moderating influence of positive health behaviors on the early life stress-migraine relationship in a sample of the Canadian adult population.Methods.-This study used data from the 2011-2012 Canadian Community Health Survey -Annual Component, a National cross-sectional survey. Adults ≥18 years of age residing in British Columbia were surveyed about stressors experienced as children/teenagers (eg, parental divorce and substance abuse exposure). Migraine was self-report of health-professional diagnosis. Positive health behaviors were measured using an index of transportation and leisure time physical activity, and self-reported frequency of vegetable and fruit consumption. Population survey weights were employed throughout and analytic models were adjusted for known confounders (n unweighted = 11,910).Results.-The weighted prevalence of migraine was 9.7% (95% CI: 9.1%, 10.2%). Odds of migraine increased as number of stressors increased: 1 early life stressor (OR = 1.18, 95% CI: 1.01, 1.39), and ≥ 2 early life stressors (OR = 1.51, 95% CI: 1.29, 1.76), compared to no stress. There was evidence of effect modification by physical activity (χ 2 (4) = 16.02, P < .001). OR = 1.20, 95% CI: 0.90, 1.61; active: OR = 0.82, 95% CI: 0.61, 1.11). This difference was not apparent for those who experienced 2 or more early life stressors (moderately active: OR = 1.67, 95% CI: 1.28, 2.17; active: OR = 1.55, 95% CI: 1.21, 1.99). Across all levels of early life stress, physically active respondents had lower odds of migraine than moderately active respondents. There was no effect modification by vegetable, fruit, and total fruit/vegetable consumption. The association between 1 early life stressor and migraine was lower for those who were physically active (moderately active:Conclusions.-Stressors experienced early in life are associated with migraine, and physical activity may ameliorate this relationship, particularly for those with exposure to a minimal level of early life stress. A higher dose of physical activity may yield greater benefit than a less intensive dose (ie, moderate activity level). However, the cross-sectional nature of this study precludes us from inferring causality, and future investigation requires prospectively collected data.

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“…Understanding the role of social determinants of migraine in aging samples is needed in order to better characterize risk and disease course among those with co-morbid medical conditions and multiple medications, which may affect treatment. [21][22][23] There is support for exercise regimes as a treatment option for migraine, 24 however, our understanding of the mechanisms in which aerobic exercise may exert positive effects, and corresponding therapeutic considerations (eg, dose) for such activities is not yet understood, hindering the use of exercise as a treatment option. 18 Non-pharmacological treatment of migraine is a rapidly expanding field, with special attention being given to a variety of lifestyle factors which may ameliorate risk, including exercise.…”

mentioning

confidence: 99%

“…Additionally, animal research on the effects of early life stress on migraine demonstrated that voluntary exercise is linked to improved healthrelated outcomes for stress-exposed rodents. [21][22][23] There is support for exercise regimes as a treatment option for migraine, 24 however, our understanding of the mechanisms in which aerobic exercise may exert positive effects, and corresponding therapeutic considerations (eg, dose) for such activities is not yet understood, hindering the use of exercise as a treatment option. 25 Gaining an understanding of the potential therapeutic benefit of physical activity in migraineurs is warranted given its affordability and ability to be administered on a large scale, 24 making it a potentially equitable treatment option.…”

mentioning

confidence: 99%

Health Behaviors and Social Determinants of Migraine in a Canadian Population‐Based Sample of Adults Aged 45‐85 Years: Findings From the CLSA

Hammond

Stinchcombe

2019

Headache

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Background Social determinants of health are well linked to adverse health outcomes, but less is known about how they relate to migraine. While much attention has been given to the role of modifiable lifestyle factors which may mitigate risk of migraine, the role of physical activity in headache management is not yet understood. Objectives The purpose of this study was to explore the relationship between social determinants of health, health behaviors, and migraine prevalence in a sample of the Canadian population aged 45‐85 years. Methods In this cross‐sectional analysis of baseline data from the Canadian Longitudinal Study on Aging, respondents were between 45 and 85 years of age and migraine was self‐report of physician diagnosis. Analyses were stratified by sex/gender (nwomen = 22,176, nmen = 21,549). Results The weighted prevalence of migraine for men and women was 7.5% and 19.6%, respectively. There were relationships between social determinants of health and migraine for both men and women. Notably, higher perceived social status was associated with a 3% reduced odds of migraine among women (OR = 0.97, 95% CI: 0.95, 0.98, P < .001). Gay and bisexual men had 50% higher odds of migraine compared to heterosexual men (OR = 1.50, 95% CI: 1.13, 1.99, P = .005). Some forms of physical activity were associated with reduced odds of migraine for women: walking for 30 minutes but less than 1 hour (OR = 0.87, 95% CI: 0.78, 0.96, P = .005), light sports for less than 30 minutes (OR = 0.86, 95% CI: 0.73, 1.00, P = .048), and 1 hour but less than 2 hours (OR = 0.85, 95% CI: 0.74, 0.97, P = .018), strenuous sports for 30 minutes but less than 1 hour (OR = 0.79, 95% CI: 0.71, 0.89, P < .001), and 1 hour but less than 2 hours (OR = 0.82, 95% CI: 0.73, 0.92, P = .001). Men who engaged in daily walking as a form of leisure time physical activity had higher odds of migraine: walking less than 30 minutes (OR = 1.21, 95% CI: 1.01, 1.45, P = .042), 2 hours but less than 4 hours (OR = 1.42, 95% CI: 1.11, 1.80, P = .005), and 4 hours or more (OR = 1.65, 95% CI: 1.18, 2.31, P = .004). Conclusions Social determinants of health are associated with migraine prevalence for both men and women. Physical activity is a modifiable lifestyle factor which merits further exploration as an intervention option for migraine headaches in aging samples, especially among older women. Greater odds of migraine among older men who walked for exercise may be explained by reverse causality.

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Adolescent voluntary exercise attenuated hippocampal innate immunity responses and depressive-like behaviors following maternal separation stress in male rats

Cited by 65 publications

References 50 publications

Short‐ and long‐term antidepressant effects of ketamine in a rat chronic unpredictable stress model

Short‐ and long‐term antidepressant effects of ketamine in a rat chronic unpredictable stress model

The Role of Positive Health Behaviors in the Relationship Between Early Life Stress and Migraine

Health Behaviors and Social Determinants of Migraine in a Canadian Population‐Based Sample of Adults Aged 45‐85 Years: Findings From the CLSA

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