Adolescent trajectories of fine motor and coordination skills and risk for schizophrenia

Dickson, Hannah; Roberts, Ruth E.; To, Melody; Wild, Kate; Loh, Max; Laurens, Kristin R.

doi:10.1016/j.schres.2019.10.018

Cited by 18 publications

(6 citation statements)

References 57 publications

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“…To this end, a motor domain has recently been added to the Research Domain Criteria (RDoC) matrix of the NIMH, facilitating future research ( Bernard and Mittal, 2015 ). In schizophrenia, reductions in motor dexterity as measured by tests such as the “grooved pegboard” are as robust as those observed in other cognitive domains, and strongly predictive of outcome ( Revheim et al, 2006 ; Lehoux, 2003 ; Lin et al, 2015 ; Dickson et al, 2020 ; Galderisi et al, 2009 ). Future studies investigating effects of tDCS on motor learning in schizophrenia and other neuropsychiatric disorders thus appear warranted as well.…”

Section: Discussionmentioning

confidence: 98%

Network-level mechanisms underlying effects of transcranial direct current stimulation (tDCS) on visuomotor learning

et al. 2020

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Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation approach in which low level currents are administered over the scalp to influence underlying brain function. Prevailing theories of tDCS focus on modulation of excitation-inhibition balance at the local stimulation location. However, network level effects are reported as well, and appear to depend upon differential underlying mechanisms. Here, we evaluated potential network-level effects of tDCS during the Serial Reaction Time Task (SRTT) using convergent EEG- and fMRI-based connectivity approaches. Motor learning manifested as a significant ( p <.0001) shift from slow to fast responses and corresponded to a significant increase in beta-coherence ( p <.0001) and fMRI connectivity ( p <.01) particularly within the visual-motor pathway. Differential patterns of tDCS effect were observed within different parametric task versions, consistent with network models. Overall, these findings demonstrate objective physiological effects of tDCS at the network level that result in effective behavioral modulation when tDCS parameters are matched to network-level requirements of the underlying task.

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Section: Discussionmentioning

confidence: 98%

Network-level mechanisms underlying effects of transcranial direct current stimulation (tDCS) on visuomotor learning

et al. 2020

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“…Disturbances in fine motor skills appear during the early developmental stages and in drug-naïve patients with schizophrenia [2,3]. Moreover, children of patients with schizophrenia have shown impaired manual dexterity relative to typically developing children [4,5], and adolescents at high risk for schizophrenia have shown reduced accuracy during a line drawing task [6]. Recent studies have revealed that motor disturbances in schizophrenia are associated with neuronal dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Positional Stability of the Non-Dominant Hand is Associated with Difficulties in Daily Functioning in Schizophrenia

Nakagawa,

Kumoi,

Sasaki

et al. 2023

Asian J OT

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Background: Patients with schizophrenia have difficulty performing activities of daily living (ADLs) that require fine motor skills. This study investigated the hand instability of 24 patients with schizophrenia and 20 healthy controls during a finger opposition task. Methods: We evaluated the path length of the hand position during the finger task from a motion capture system. Subjective difficulties in ADLs were assessed using a visual analog scale. Results: The path lengths of both hands were significantly greater for patients with schizophrenia than for healthy controls. Significant associations were found between the path length of the non-dominant hand and subjective difficulties encountered by patients with schizophrenia while performing ADLs. Conclusion:The findings suggest that instability in the non-dominant hand is a potential marker of daily functioning in schizophrenia.

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“…Changes at all levels of organization of motor acts (sensory input, neural networks, muscle reaction) can affect the behavior of an individual. It is believed that motor dysfunctions can appear at the early stages of ontogeny in individuals who later develop a psychopathology, in particular, psychotic reactions, and can represent a premorbid characteristic of these states [ 16 ]. However, the development of motor skills is a dynamic process.…”

Section: Introductionmentioning

confidence: 99%

Features of Psychomotor Coordination in Adolescents with Neuropsychiatric Pathology Enrolled in a Standard Educational Program

Mavrenkova

Lebedeva

et al. 2022

Brain Sciences

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The imbalance between the speed and accuracy of cognitive-motor operations can lead to the formation of abnormal behavioral programs fraught with serious negative consequences for the individual. For successful correction and prevention of social disadaptation in adolescents with nervous and mental diseases and functional disorders in mental sphere in general education schools, the peculiarities of their psychomotor activity should be taken into account. We measured some parameters of visual-motor coordination and sensorimotor reaction in adolescents with mental disorders with (n = 36) or without (n = 27) organic brain damage. Adolescents from both groups showed higher speed, but poorer accuracy and smoothness, of movements than typically developing students (n = 70). The visual and acoustic reaction times were longer in adolescents with mental disorders without organic brain damage than in reference groups.

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Adolescent trajectories of fine motor and coordination skills and risk for schizophrenia

Cited by 18 publications

References 57 publications

Network-level mechanisms underlying effects of transcranial direct current stimulation (tDCS) on visuomotor learning

Network-level mechanisms underlying effects of transcranial direct current stimulation (tDCS) on visuomotor learning

Positional Stability of the Non-Dominant Hand is Associated with Difficulties in Daily Functioning in Schizophrenia

Features of Psychomotor Coordination in Adolescents with Neuropsychiatric Pathology Enrolled in a Standard Educational Program

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