Adolescent Thyroid Disorders and Risk for Type 2 Diabetes in Young Adulthood

Bardugo, Aya; Derazne, Estela; Zucker, Inbar; Bendor, Cole D.; Puris, Gal; Lutski, Miri; Pinhas‐Hamiel, Orit; Mosenzon, Ofri; Schechter, Meir; Tzur, Dorit; Afek, Arnon; Tirosh, Amir; Gerstein, Hertzel C.; Twig, Gilad

doi:10.1210/clinem/dgab382

Cited by 9 publications

(6 citation statements)

References 36 publications

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“…Therefore, further investigating the effects of thyroid function on diabetes is necessary. A clinical research article by Bardugo et al 3 showed an association of thyroid disorders with the risk of young-onset (YOD) T2D. This study's major finding was that thyroid disorders diagnosed in adolescents were risk factors for early onset T2D 4 in both men and women.…”

Section: E T T E R T O T H E E D I T Omentioning

confidence: 77%

Letter regarding ‘Association of thyroid function with non‐alcoholic fatty liver disease in recent‐onset diabetes’

Hsiao,

Liaw

2024

Liver International

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Section: E T T E R T O T H E E D I T Omentioning

confidence: 77%

Letter regarding ‘Association of thyroid function with non‐alcoholic fatty liver disease in recent‐onset diabetes’

Hsiao,

Liaw

2024

Liver International

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“…Thyroid diseases and T2D often coexist in the same patients, reinforcing the hypothesis of a reciprocal relationship between these two disorders [9,[98][99][100]. Indeed, THs exert a series of effects on glucose metabolism, as suggested by the action of THs on the pancreas in modulating the development and function of pancreatic β-cells [101,102].…”

Section: Thyroid and Type 2 Diabetesmentioning

confidence: 83%

Selenium and Selenoproteins at the Intersection of Type 2 Diabetes and Thyroid Pathophysiology

Gorini

Vassalle

2022

Antioxidants

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Type 2 diabetes (T2D) is considered one of the largest global public-health concerns, affecting approximately more than 400 million individuals worldwide. The pathogenesis of T2D is very complex and, among the modifiable risk factors, selenium (Se) has recently emerged as a determinant of T2D pathogenesis and progression. Selenium is considered an essential element with antioxidant properties, and is incorporated into the selenoproteins involved in the antioxidant response. Furthermore, deiodinases, the enzymes responsible for homeostasis and for controlling the activity of thyroid hormones (THs), contain Se. Given the crucial action of oxidative stress in the onset of insulin resistance (IR) and T2D, and the close connection between THs and glucose metabolism, Se may be involved in these fundamental relationships; it may cover a dual role, both as a protective factor and as a risk factor of T2D, depending on its basal plasma concentration and the individual’s diet intake. In this review we discuss the current evidence (from experimental, observational and randomized clinical studies) on how Se is associated with the occurrence of T2D and its influence on the relationship between thyroid pathophysiology, IR and T2D.

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“…Data regarding immigration history and place of residence were received from the Ministry of Interior [ 26 ]. Residential socioeconomic status was classified into three groups (low/medium/high) based on criteria of the Israeli Bureau of Statistics [ 26 , 27 ].…”

Section: Methodsmentioning

confidence: 99%

The opposing trends of body mass index and blood pressure during 1977–2020; nationwide registry of 2.8 million male and female adolescents

Fishman

Zloof

Orr

et al. 2021

Cardiovasc Diabetol

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Background Elevated blood pressure among adolescents has been shown to be associated with future adverse cardiovascular outcomes and early onset diabetes. Most data regarding systolic and diastolic blood pressure trends are based on surveys of selected populations within 10–20-year periods. The goal of this study was to characterize the secular trend of blood pressure given the rising prevalence of adolescent obesity. Methods This nationwide population-based study included 2,785,515 Israeli adolescents (41.6% females, mean age 17.4 years) who were medically evaluated and whose weight, height and blood pressure were measured, prior to mandatory military service between 1977 and 2020. The study period was divided into 5-year intervals. Linear regression models were used to describe the P for trend along the time intervals. Analysis of covariance was used to calculate means of blood pressure adjusted for body mass index. Results During the study period, the mean body mass index increased by 2.1 and 1.6 kg/m2 in males and females, respectively (P for trend < 0.001 in both sexes). The mean diastolic blood pressure decreased by 3.6 mmHg in males and by 2.9 mmHg in females (P < 0.001 in both sexes). The mean systolic blood pressure increased by 1.6 mmHg in males and decreased by 1.9 mmHg in females. These trends were also consistent when blood pressure values were adjusted to body mass index. Conclusion Despite the increase in body mass index over the last four decades, diastolic blood pressure decreased in both sexes while systolic blood pressure increased slightly in males and decreased in females.

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Adolescent Thyroid Disorders and Risk for Type 2 Diabetes in Young Adulthood

Cited by 9 publications

References 36 publications

Letter regarding ‘Association of thyroid function with non‐alcoholic fatty liver disease in recent‐onset diabetes’

Letter regarding ‘Association of thyroid function with non‐alcoholic fatty liver disease in recent‐onset diabetes’

Selenium and Selenoproteins at the Intersection of Type 2 Diabetes and Thyroid Pathophysiology

The opposing trends of body mass index and blood pressure during 1977–2020; nationwide registry of 2.8 million male and female adolescents

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