Abstract:Adolescent inhibition of thalamo-cortical projections leads to long lasting deficits in prefrontal cortex function and cognition in the adult mouse. While this suggests a role of thalamic activity in prefrontal cortex maturation, it is unclear how inhibition of these projections affects prefrontal network function during adolescence. Here, we used chemogenetic tools to inhibit thalamo-prefrontal projections in the mouse from postnatal day 20-35 and measured synaptic inputs to prefrontal pyramidal neurons by la… Show more
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