Adolescent suicide attempts and ideation are linked to brain function during peer interactions

Harms, Madeline B.; Casement, Melynda D.; Teoh, Jia Yuan; Ruiz, Sarah K.; Scott, Hannah; Wedan, Riley; Quevedo, Karina

doi:10.1016/j.pscychresns.2019.05.001

Cited by 50 publications

(38 citation statements)

References 60 publications

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“…However, there were no significantly statistical differences in the GMVs of the right and left middle frontal gyrus between the mood disorder patients with SI and the mood disorders with SAs groups. One fMRI study found that adolescent SA youth showed significantly lower activity in related regions compared to adolescent SI youth [26], which is not consistent with our results. The inconsistency may be related to differences in methods and patient characteristics.…”

Section: Discussioncontrasting

confidence: 99%

“…Previous studies have also supported the middle frontal gyrus being involved in suicidal behavior in mood disorders, and are consistent with our findings. For example, functional MRI studies showed that patients with MDD and SAs had abnormal brain activity in the middle frontal gyrus when compared to individuals without SAs [26,[28][29][30]. Additionally, patients with MDD and SI also showed a distinct brain network characterized by functional connectivity differences in the middle frontal gyrus versus the MDD patients without SI [31,32].…”

Section: Discussionmentioning

confidence: 99%

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Gray matter volume alterations associated with suicidal ideation and suicide attempts in patients with mood disorders

et al. 2020

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Background Mood disorders are severe mental disorders related to increased suicidal behavior. Finding neural features for suicidal behavior, including suicide attempts (SAs) and suicidal ideation (SI), in mood disorders may be helpful in preventing suicidal behavior. Methods Subjects consisted of 70 patients with mood disorders and suicidal behavior, 128 patients with mood disorders without suicidal behavior (mood disorders control, MC), and 145 health control (HC) individuals. All participants underwent structural magnetic resonance imaging (MRI). We used voxel-based morphometry (VBM) techniques to examine gray matter volumes (GMVs). Results Significant differences were found in GMVs of the left and right middle frontal gyrus among the patients with mood disorders and suicidal behavior, MC, and HC. Post hoc comparisons showed significant differences in the GMVs of the above regions across all three groups (P < 0.01): HC > MC > mood disorders with suicidal behavior. However, there were no significant differences in the GMVs of the left and right middle frontal gyrus between the mood disorders with SI and mood disorders with SAs groups. Conclusions These findings provide evidence that abnormal regional GMV in the middle frontal gyrus is associated with suicidal behavior in mood disorders. Further investigation is warranted to determine whether the GMV alterations in mood disorders with SI are different from these in mood disorders with SAs.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gray matter volume alterations associated with suicidal ideation and suicide attempts in patients with mood disorders

et al. 2020

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“…A rs-fMRI study unveiled differential activation of the STG in depressed patients with SA compared to patients without SA and HCs (Weng et al, 2019). A recent task-based (completed a version of the Cyberball peer interaction) fMRI study demonstrated that altered brain activity in the STG in depressed adolescents with high suicide ideation was significantly correlated with negative emotionality, social functioning and cognitive control (Harms et al, 2019). Moreover, previous task-based MRI studies in borderline personality disorder found that the STG mediated a 'reflexive' response to visual social inputs (Buchheim et al, 2008), especially negative visual stimuli caused by perceived rejection and social disappointment has been thought to be the most common precipitant of suicidal behavior (Soloff et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Characteristics of temporal dynamics of intrinsic brain activity in unmedicated bipolar disorder with suicidality

Gong

Chen

Zhou

et al. 2020

Aust N Z J Psychiatry

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Background: Bipolar disorder is associated with a high risk of suicide. Routine neuroimaging examination exhibited that bipolar disorder with suicidality was associated with brain structural and functional changes. However, the alterations of brain dynamics have still remained elusive. Purpose: To investigate the alterations of brain dynamics in unmedicated bipolar disorder II depression with suicidality and predict the severity of suicidality. Materials and Methods: This prospective study included 106 bipolar disorder II participants (20 with suicidal attempt, 35 with suicidal ideation, 51 without suicidal ideation) and 50 healthy controls who underwent resting-state functional magnetic resonance imaging between February 2016 and December 2017. We first used sliding window analysis to evaluate the dynamic amplitude of low-frequency fluctuations. Then, we predicted the severity of suicidality using a multivariate regression model. Results: One-way analysis of covariance revealed that the dynamic amplitude of low-frequency fluctuations in the right temporal pole, inferior temporal gyrus, superior temporal gyrus and the bilateral precuneus/posterior cingulate cortex was significantly different among the four groups. Post hoc pairwise comparisons revealed that dynamic amplitude of low-frequency fluctuations was remarkably decreased in the bilateral precuneus/posterior cingulate cortex in the three bipolar disorder II groups compared with that in healthy controls group. Increased dynamic amplitude of low-frequency fluctuations was found in the right superior temporal gyrus and inferior temporal gyrus in the suicidal attempt group compared with that in the other groups, and in the right temporal pole in the suicidal attempt group compared with that in the suicidal ideation and healthy controls groups. Importantly, these temporal variabilities could be used to predict the severity of suicidality ( r = 0.330, p = 0.036), whereas static amplitude of low-frequency fluctuations couldn’t ( r = –0.050, p = 0.532). Conclusion: Our findings indicated that alterations of temporal variability in the precuneus/posterior cingulate cortex are such a common feature of bipolar disorder patients. Besides, the severity of suicidality could be predicted by the dynamic amplitude of low-frequency fluctuations abnormalities rather than static amplitude of low-frequency fluctuations abnormalities, which is the first evidence of dynamic brain alterations in bipolar disorder patients with suicidality. The proposed predictive model may be advantageous for clinical applications.

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“…Altered rostral ACC activity also has been linked to other characteristics of suicidal individuals, including rumination and negative selfreferential thinking [42][43][44] . Moreover, task-related ACC activation [70][71][72] and functional connectivity to other emotion-regulating regions 71 differ between adolescent suicide attempters and depressed non-attempters, suggesting that suicidality may involve ACC functions distinct from those related to depressive mood states. Spectroscopic studies comparing depressed and healthy adolescents have found glutamatergic deficits in the ACC [33][34][35] and diminished NAA concentrations in ACC and medial prefrontal cortex 36 , although, to our knowledge, none have directly compared cortical neurochemical profiles of suicidal and nonsuicidal youth.…”

Section: Discussionmentioning

confidence: 99%

Altered anterior cingulate glutamatergic metabolism in depressed adolescents with current suicidal ideation

et al. 2020

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The anterior cingulate cortex (ACC) is involved in emotion regulation and salience processing. Prior research has implicated ACC dysfunction in suicidal ideation (SI) and suicidal behavior. This study aimed to quantify ACC glutamatergic concentrations and to examine relationships with SI in a sample of healthy and depressed adolescents. Forty adolescents underwent clinical evaluation and proton magnetic resonance spectroscopy (1 H-MRS) at 3 T, utilizing a 2-dimensional J-averaged PRESS sequence sampling a medial pregenual ACC voxel. Cerebrospinal fluidcorrected ACC metabolite concentrations were compared between healthy control (HC, n = 16), depressed without SI (Dep/SI−, n = 13), and depressed with SI (Dep/SI+, n = 11) youth using general linear models covarying for age, sex, and psychotropic medication use. Relationships between ACC metabolites and continuous measures of SI were examined using multiple linear regressions. ROC analysis was used to determine the ability of glutamate+glutamine (Glx) and the N-acetylaspartate (NAA)/Glx ratio to discriminate Dep/SI− and Dep/SI+ adolescents. Dep/SI+ adolescents had higher Glx than Dep/SI− participants (p adj = 0.012) and had lower NAA/Glx than both Dep/SI− (p adj = 0.002) and HC adolescents (p adj = 0.039). There were significant relationships between SI intensity and Glx (p FDR = 0.026), SI severity and NAA/Glx (p FDR = 0.012), and SI intensity and NAA/Glx (p FDR = 0.004). ACC Glx and NAA/Glx discriminated Dep/SI− from Dep/SI+ participants. Uncoupled NAA−glutamatergic metabolism in the ACC may play a role in suicidal ideation and behavior. Longitudinal studies are needed to establish whether aberrant glutamatergic metabolism corresponds to acute or chronic suicide risk. Glutamatergic biomarkers may be promising targets for novel risk assessment and interventional strategies for suicidal ideation and behavior.

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Adolescent suicide attempts and ideation are linked to brain function during peer interactions

Cited by 50 publications

References 60 publications

Gray matter volume alterations associated with suicidal ideation and suicide attempts in patients with mood disorders

Gray matter volume alterations associated with suicidal ideation and suicide attempts in patients with mood disorders

Characteristics of temporal dynamics of intrinsic brain activity in unmedicated bipolar disorder with suicidality

Altered anterior cingulate glutamatergic metabolism in depressed adolescents with current suicidal ideation

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