Abstract:AbstractNeurodevelopmental explanations for adolescent substance use have focused on heightened sensitivity of the brain’s reward system, centered around the ventral striatum (VS). Recent evidence demonstrates increased functional connectivity between the VS and hippocampus in adolescents relative to adults, suggesting that the adolescent brain may learn from subsequent exposure to risks/rewards. However, a link between VS-hippocampal circuitry and adolescent substance use has … Show more
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