Adolescent Premature Ovarian Insufficiency Following Human Papillomavirus Vaccination

Abstract

Three young women who developed premature ovarian insufficiency following quadrivalent human papillomavirus (HPV) vaccination presented to a general practitioner in rural New South Wales, Australia. The unrelated girls were aged 16, 16, and 18 years at diagnosis. Each had received HPV vaccinations prior to the onset of ovarian decline. Vaccinations had been administered in different regions of the state of New South Wales and the 3 girls lived in different towns in that state. Each had been prescribed the oral contraceptive pill to treat menstrual cycle abnormalities prior to investigation and diagnosis. Vaccine research does not present an ovary histology report of tested rats but does present a testicular histology report. Enduring ovarian capacity and duration of function following vaccination is unresearched in preclinical studies, clinical and postlicensure studies. Postmarketing surveillance does not accurately represent diagnoses in adverse event notifications and can neither represent unnotified cases nor compare incident statistics with vaccine course administration rates. The potential significance of a case series of adolescents with idiopathic premature ovarian insufficiency following HPV vaccination presenting to a general practice warrants further research. Preservation of reproductive health is a primary concern in the recipient target group. Since this group includes all prepubertal and pubertal young women, demonstration of ongoing, uncompromised safety for the ovary is urgently required. This matter needs to be resolved for the purposes of population health and public vaccine confidence.

Autoimmune/Inflammatory Syndrome Induced by Adjuvants and Thyroid Autoimmunity

“…Case reports, cohort and case–control studies on ASIA syndrome, and the majority of the endocrinopathies are still scarce. Lately, primary ovarian failure (POF) has been linked to ASIA, especially after vaccination (21–25). …”

“…Problems of quadrivalent HPV vaccine introduction in the market were wisely pointed by Little and Ward (25). They reported three other cases of young women who develop POF after having quadrivalent HPV vaccine and questioned some issues about its safety.…”

Case Presentation & Review of Literature for a Rare Case of Adolescent Premature Ovarian Insufficiency

“…Miss A had a normal pelvic scan indicating of follicle dysfunction to be the likely mechanism. In few case studies its occurrence in adolescents has also been linked to HPV vaccination; however there has been no clear mechanism stated and may require more research in that area [6,7], interestingly Miss A did have HPV vaccine as a part of national immunisation.…”

Naprotecnología: ciencia y persona en la infección por el virus del papiloma humano (VPH) en mujeres y preadolescencentes

“…Si la exposición subsiguiente después de la inmunización sirve como un refuerzo, la duración de la protección puede ser prolongada, especialmente en aquellos casos involucrados en comportamientos de alto riesgo, como tener más parejas sexuales y, por tanto, una mayor exposición al VPH, según algunos autores (112)(113)(114). Finalmente, cabe anotar que se han documentado algunos efectos secundarios (115)(116)(117)(118)(119); en este sentido, al respecto existen entidades encargadas de regular este tipo de información, basadas en los posibles eventos adversos asociados con las vacunas (120)(121)(122)(123).…”