Adolescent Obesity as a Risk Factor for High-Level Nicotine Addiction in Young Women

Hussaini, Aliya; Nicholson, Lisa; Shera, David; Stettler, Nicolas; Kinsman, Sara B.

doi:10.1016/j.jadohealth.2011.04.001

Cited by 22 publications

(18 citation statements)

References 35 publications

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“…Clinical studies suggest that childhood weight problems and unhealthy eating patterns can lower the age of onset of nicotine smoking and increase withdrawal symptoms during times of abstinence (Saules et al 2007). A close relationship between dietary fat and nicotine use is also evident in studies showing that obese individuals have double the risk for developing nicotine addiction (Hussaini et al 2011) and, conversely, that smokers consume significantly greater amounts of high calorie, fat-rich foods (Dallongeville et al 1998). Of particular note is evidence demonstrating that maternal consumption of these unhealthy diets during pregnancy, in addition to leading to childhood obesity and hyperlipidemia (Dietz 1998; Hannon et al 2005), can program behaviors in the offspring that are likely to increase vulnerability to drug abuse.…”

Section: Introductionmentioning

confidence: 96%

Stimulation of nicotine reward and central cholinergic activity in Sprague–Dawley rats exposed perinatally to a fat-rich diet

et al. 2013

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Rationale While clinical studies show maternal consumption of palatable fat-rich diets during pregnancy to negatively impact the children’s behaviors and increase their vulnerability to drug abuse, the precise behavioral and neurochemical mechanisms mediating these phenomena have yet to be examined. Objective The study examined in rats whether gestational exposure to a high-fat diet (HFD) can increase the offspring’s propensity to use nicotine and whether disturbances in central nicotinic cholinergic signaling accompany this behavioral effect. Methods Rat offspring exposed perinatally to a HFD or Chow diet were characterized in terms of their nicotine self-administration behavior in a series of operant response experiments and the activity of acetylcholinesterase (AChE) and density of nicotinic ACh receptors (nAChRs) in different brain areas. Result Perinatal HFD compared to Chow exposure increased nicotine-self administration behavior during fixed-ratio and dose-response testing and caused an increase in breakpoint using progressive ratio testing, while nicotine-seeking in response to nicotine prime-induced reinstatement was reduced. This behavioral change induced by the HFD was associated with a significant reduction in activity of AChE in the midbrain, hypothalamus and striatum and increased density of β2-nAChRs in the ventral tegmental area and substantia nigra and of α7-nAChRs in the lateral and ventromedial hypothalamus. Conclusions Perinatal exposure to a HFD increases the vulnerability of the offspring to excessive nicotine use by enhancing its reward potential, and these behavioral changes are accompanied by a stimulation of nicotinic cholinergic signaling in mesostriatal and hypothalamic brain areas important for reinforcement and consummatory behavior.

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Section: Introductionmentioning

confidence: 96%

Stimulation of nicotine reward and central cholinergic activity in Sprague–Dawley rats exposed perinatally to a fat-rich diet

et al. 2013

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“…[1] Obesity is the leading cause of preventable deaths involved with cardiovascular risks, endothelial dysfunction, diabetes mellitus, premature puberty, and obstructive sleep disorder etc. [2] The obesity is associated with many health complications among school-goers that include hypertension [3] high-level nicotine addiction, [4] and depression. [5] Interestingly, some studies in the past have associated school absenteeism with obesity as it has direct impact on the psychosocial and physical characteristics.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of adolescent obesity among high school students of Kerala, South India

Remesh¹

2012

Arch Pharma Pract

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Objectives:To study the prevalence of obesity among high school students of age 15-17 years and identify the associated risk factors. Materials and Methods: A descriptive cross-sectional study involving the measurement of height and weight and calculation of body mass index among high school students of Kottukal and Pallichal localities of Trivandrum districts in Kerala, South India. A study questionnaire was administered among the participants and their parents to understand the relationship of food intake, parental obesity, and physical activity to obesity. Results: Of the 560 students enrolled, 49 (8.75%) were overweight and 27 (4.82%) were obese. With this, the prevalence of obese is computed as 4.8%. The parental obesity posed a significant risk factor among the study population. Conclusion: Creating awareness among adults and school-goers on the negative health effects of obesity, the key for maintaining good health.

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“…Longitudinal studies, on the other hand, are less conclusive. Some studies have indicated that overweight and obese adolescents are more likely than non-overweight/obese adolescents to initiate smoking or become regular smokers (Caria, Bellocco, Zambon, Horton, & Galanti, 2009; Cawley, Markowitz, & Tauras, 2004; Hussaini, Nicholson, Shera, Stettler, & Kinsman, 2011; Lanza, Grella, & Chung, 2014). Conversely, other studies have shown that adolescent obesity is linked to lower risk of cigarette smoking initiation or generally not associated with future problematic substance use (Austin & Gortmaker, 2001; Mustillo, Worthman, Erkanli, Keeler, & Angold 2003; Pasch, Velazquez, Cance, Moe, & Lytle, 2012).…”

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confidence: 99%

Adolescent obesity and future substance use: Incorporating the psychosocial context

Lanza

Grella

2015

Journal of Adolescence

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A growing body of work has shown that obese adolescents are at risk of engaging in problematic substance use, but mixed findings highlight the complexity of the relationship. Incorporating the psychosocial context into this research may inform past discrepancies. The current study assessed whether obese adolescents had a higher likelihood of experiencing a psychosocial context that predicted problematic substance use in young adulthood. Latent class analysis on 10,637 adolescents from The National Longitudinal Study of Adolescent to Adult Health (Add Health) identified four psychosocial classes in adolescence: Adjusted, Deviant Peer/Victimization, Moderate Depression, and Maladjusted. Obese adolescents were more likely to belong to the Maladjusted class, characterized by higher levels of depression and deviant peer affiliation. Those in the Maladjusted class had the second highest levels of cigarette smoking and marijuana use in young adulthood. Obese adolescents’ psychosocial context should be considered in future research linking obesity and substance use.

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Adolescent Obesity as a Risk Factor for High-Level Nicotine Addiction in Young Women

Cited by 22 publications

References 35 publications

Stimulation of nicotine reward and central cholinergic activity in Sprague–Dawley rats exposed perinatally to a fat-rich diet

Stimulation of nicotine reward and central cholinergic activity in Sprague–Dawley rats exposed perinatally to a fat-rich diet

Prevalence of adolescent obesity among high school students of Kerala, South India

Adolescent obesity and future substance use: Incorporating the psychosocial context

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