Adolescent obesity and adult male breast cancer in a cohort of 1,382,093 men

Keinan‐Boker, Lital; Levine, Hagai; Leiba, Adi; Derazne, Estela; Kark, Jeremy D.

doi:10.1002/ijc.31121

Cited by 20 publications

(23 citation statements)

References 19 publications

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“…Concerning obesity and in a recent study in israel, it is proved that adolescent overweight and obesity are associated with increased risk of mal breast cancer, suggesting a modifiable risk factor potentially allowing for early intervention [9].…”

Section: Discussionmentioning

confidence: 98%

Echo-Mammographic and Anatomo-Pathological Aspects of Male Breast Cancer in Togo

N’timon¹,

Darré²,

Dagbe³

et al. 2017

OJRad

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Studies of male breast cancer are rare in Africa. In Togo in particular, no work has focused on the epidemiological, mammo-echographic, pathological, therapeutic or prognostic aspects of male breast cancer. The aim of this study is to report cases of male breast cancer in Togo by describing the main epidemiological, mammo-echographic and pathological aspects. This was a retrospective, descriptive and analytical study of 10 cases of male patients presenting with breast cancer confirmed by the pathologic examination on the echoguided samples over a period of 6 years in University Teaching Hospital in Lomé. A total of ten patients were retained. The mean age of patients was 55 years with extremes of 39 years and 65 years. All patients had a palpable breast mass. The lesions were classified in 60% American College of Radiology (ACR) 5 and 40% ACR 4. The axillary lymph node invasion rate was 40%. Infiltrating ductal carcinoma was the histologic type diagnosed in all patients. Any breast mass in an elderly male subject is suspected with high predictive value. Mammography ultrasound plays an important role in the diagnosis alongside pathology.

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Section: Discussionmentioning

confidence: 98%

Echo-Mammographic and Anatomo-Pathological Aspects of Male Breast Cancer in Togo

N’timon¹,

Darré²,

Dagbe³

et al. 2017

OJRad

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“…Most of these articles (n = 54) were excluded because they reported BMI only in adulthood (>30 years). We also excluded eight articles (71)(72)(73)(74)(75)(76)(77)(78) investigating other cancer types, three articles (79-81) investigating pancreatic cancer mortality and an article (82) that did not report 95% CIs. Furthermore, two articles (83,84) were superseded by an updated article (62) that also reported data for the same population.…”

Section: Literature Reviewmentioning

confidence: 99%

Body fatness at a young age and risks of eight types of cancer: systematic review and meta‐analysis of observational studies

Hidayat

Shi

2018

Obesity Reviews

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The associations between body fatness at a young age (childhood, adolescence and young adulthood; age ≤ 30 years) and diffuse large B-cell lymphoma (DLBCL), oesophageal adenocarcinoma, gastric cardia cancer, hepatocellular carcinoma, multiple myeloma, pancreatic cancer, renal cell cancer and thyroid cancer remain inconclusive. We performed a comprehensive systematic literature review and meta-analysis of observational studies to clarify the associations between body fatness at a young age and the risks of these cancers. PubMed and Web of Science databases were searched for relevant observational studies. Fifty-six articles yielded data on 27,559 cancer cases, including 3,170 DLBCL, 1,491 oesophageal adenocarcinoma, 1,103 gastric cardia cancer, 1,067 hepatocellular carcinoma, 3,090 multiple myeloma, 7,220 pancreatic cancer, 6,212 renal cell cancer and 4,206 thyroid cancer cases. Each 5 kg m increase in body mass index at a young age was positively associated with DLBCL (relative risk [RR] 1.21, 95% confidence interval [CI] 1.09, 1.35), oesophageal adenocarcinoma (RR 1.88, 95% CI 1.37, 2.57), gastric cardia cancer (RR 1.59, 95% CI 1.15, 2.21), hepatocellular carcinoma (RR 1.31, 95% CI 1.13, 1.51), multiple myeloma (RR 1.23, 95% CI 1.15, 1.30), pancreatic cancer (RR 1.17, 95% CI 1.11, 1.24), renal cell cancer (RR 1.22, 95% CI 1.16, 1.28) and thyroid cancer (RR 1.12, 95% CI 1.07, 1.17). In summary, higher body fatness at a young age increases the risks of developing various types of cancer later in life. Prevention of overweight and obesity in children, adolescents and young adults should therefore be emphasized to reverse the obesity epidemic and thereby avoid further increases in the burden of cancer attributed to excess body fatness.

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“…These show a clear dose-response rate increasing BMI and MBC risk. Using a different approach, Keinan-Boker et al examined the impact of adolescent BMI on subsequent risk of MBC (Keinan-Boker et al 2018). They amassed a cohort of 1,382,093 Israeli males aged between 16 and 19 years of age.…”

Section: Endocrine Risk Factorsmentioning

confidence: 99%

The endocrinology of male breast cancer

Fentiman¹

2018

Endocrine-Related Cancer

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Male breast cancer (MBC) is a rare disease but, as a result of epidemiological collaborations, there is now greater clarity concerning endocrine risk factors. The significant rise in global age-standardised mean BMI in men is likely to lead to increases in incidence of maturity-onset diabetes and MBC. The metabolic changes accompanying obesity decrease androgens and sex hormone-binding globulin (SHBG), thereby increasing available oestrogens. The higher rates of MBC in North and Equatorial Africa are largely due to liver damage from endemic bilharziasis and hepatitis B causing elevated oestradiol (E) levels from hepatic conversion of androgen. Klinefelter's syndrome (XXY) is associated with a 50-fold increase in incidence of MBC compared with XY males, and this is the most pronounced evidence for testicular malfunction amplifying risk. Delay in presentation means that up to 40% of cases have stage III or stage IV disease at diagnosis. No randomised controlled trials have been reported on endocrine treatment of advanced disease or adjuvant/neoadjuvant therapy following or preceding surgery. Tamoxifen is the most effective endocrine therapy, but side effects can lead to non-compliance in a substantial number of men. Aromatase inhibitors are less effective because they do not inhibit testicular oestrogen production. There is an urgent need for collaborative trials to provide an evidence base for the most effective endocrine and least toxic therapies for men with breast cancer.

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Adolescent obesity and adult male breast cancer in a cohort of 1,382,093 men

Cited by 20 publications

References 19 publications

Echo-Mammographic and Anatomo-Pathological Aspects of Male Breast Cancer in Togo

Echo-Mammographic and Anatomo-Pathological Aspects of Male Breast Cancer in Togo

Body fatness at a young age and risks of eight types of cancer: systematic review and meta‐analysis of observational studies

The endocrinology of male breast cancer

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