Adolescent nicotine induces persisting changes in development of neural connectivity

Smith, Robert F.; McDonald, Craig G.; Bergstrom, Hadley C.; Ehlinger, Daniel G.; Brielmaier, Jennifer

doi:10.1016/j.neubiorev.2015.05.019

Cited by 96 publications

(74 citation statements)

References 122 publications

(144 reference statements)

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“…Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2014). A growing body of evidence from both human and animal studies indicates that adolescents are more susceptible than adults to the cellular and behavioral effects of nicotine, the main addictive component of tobacco (Adriani and Laviola, 2004; Counotte et al, 2011; Lydon et al, 2014; Smith et al, 2015). …”

Section: Introductionmentioning

confidence: 99%

Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2α

Placzek

Molfese

Khatiwada

et al. 2016

eLife

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Adolescents are particularly vulnerable to nicotine, the principal addictive component driving tobacco smoking. In a companion study, we found that reduced activity of the translation initiation factor eIF2α underlies the hypersensitivity of adolescent mice to the effects of cocaine. Here we report that nicotine potentiates excitatory synaptic transmission in ventral tegmental area dopaminergic neurons more readily in adolescent mice compared to adults. Adult mice with genetic or pharmacological reduction in p-eIF2α-mediated translation are more susceptible to nicotine’s synaptic effects, like adolescents. When we investigated the influence of allelic variability of the Eif2s1 gene (encoding eIF2α) on reward-related neuronal responses in human smokers, we found that a single nucleotide polymorphism in the Eif2s1 gene modulates mesolimbic neuronal reward responses in human smokers. These findings suggest that p-eIF2α regulates synaptic actions of nicotine in both mice and humans, and that reduced p-eIF2α may enhance susceptibility to nicotine (and other drugs of abuse) during adolescence.DOI: http://dx.doi.org/10.7554/eLife.12056.001

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Section: Introductionmentioning

confidence: 99%

Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2α

Placzek

Molfese

Khatiwada

et al. 2016

eLife

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“…2 In the United States, popular forms of SLT include chewing tobacco or moist snuff. Chewing tobacco is made of long strands of tobacco, whereas snuff tobacco is a fine-grained and comes in a moist blend that usually is used orally.…”

Section: Epidemiologymentioning

confidence: 99%

“…Chewing tobacco is made of long strands of tobacco, whereas snuff tobacco is a fine-grained and comes in a moist blend that usually is used orally. 2 …”

Section: Epidemiologymentioning

confidence: 99%

Tobacco Use Disorders

Klein

2016

Child and Adolescent Psychiatric Clinics of North America

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Synopsis Tobacco use is a pervasive public health problem and the leading cause of preventable morbidity and mortality in the United States. This article reviews the epidemiology of tobacco use in youth, with a description of cigarettes, alternative tobacco product, and poly-tobacco use patterns among the general population and among adolescents with psychiatric and/or substance use disorders. The article also provides an update on the diagnosis and assessment of tobacco use disorder in adolescents, with a particular focus on the clinical management of tobacco use in adolescents with co-occurring disorders.

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“…To date, most research on nicotine use during adolescence has focused on how exposure to nicotine during this critical stage of brain development can lead to long-term changes in neural circuitry and behavior later in life [5, 6]. By comparison, relatively few studies have considered the influence of nicotine on cognitive performance during adolescence.…”

mentioning

confidence: 99%

Nicotine administration enhances negative occasion setting in adolescent rats

Meyer

Chodakewitz

Bucci

2016

Behavioural Brain Research

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Substantial research has established that exposure to nicotine during adolescence can lead to long-term changes in neural circuitry and behavior. However, relatively few studies have considered the effects of nicotine use on cognition during this critical stage of brain development. This is significant because the influence of nicotine on cognitive performance during adolescence may contribute to the development of regular nicotine use. For example, improvements in cognitive functioning may increase the perceived value of smoking and facilitate impulses to smoke. To address this, the present research tested the effects of nicotine on a form of inhibitory learning during adolescence. Specifically, adolescent rats were exposed to nicotine as they were trained in a negative occasion setting paradigm, in which successful performance depends on learning the conditions under which it is, or is not, appropriate to respond to a target stimulus. Here, we found that nicotine administration enhances negative occasion setting in adolescents. In addition, nicotine increased the amount of orienting behavior directed toward the inhibitory stimulus, suggesting that improvements in this form of behavioral inhibition may be attributed to nicotine-induced increases in attentional processing. These results may help elucidate the factors that contribute to the onset as well as continued use of products containing nicotine during adolescence and provide insight to increase the effectiveness of interventions targeted at reducing the prevalence of adolescent smoking.

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Adolescent nicotine induces persisting changes in development of neural connectivity

Cited by 96 publications

References 122 publications

Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2α

Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2α

Tobacco Use Disorders

Nicotine administration enhances negative occasion setting in adolescent rats

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