Adolescent morphine exposure induces immediate and long-term increases in impulsive behavior

Moazen, Parisa; Azizi, Hossein; Salmanzadeh, Hamed; Semnanian, Saeed

doi:10.1007/s00213-018-5051-0

Cited by 31 publications

(13 citation statements)

References 68 publications

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“…However, mice performances in this task are equivalent to rats, a few studies showing indeed superior motor control of task performance (Humby et al, 1999; Sanchez-Roige et al, 2012; Cope et al, 2016; Higgins and Silenieks, 2017). Exposure to drugs of abuse is typically correlated to robust increases in impulsive behavior, often specifically in adolescent rodents but not in adults, measured with the 5-CSRTT or the two-choice reaction time task, a simplified version of the former (Burton and Fletcher, 2012; Siemian et al, 2017; Moazen et al, 2018; Xue et al, 2018). Interestingly, a study compared cocaine and a cocaine-associated cue to compete for attention, and concluded that while cocaine severely disrupted the well-learned sustained attention task in rats, the cocaine-associated cue induced cocaine seeking but failed to impair the task (Pitchers et al, 2017c).…”

Section: Individual Variation In Addiction-related Behaviorsmentioning

confidence: 99%

Understanding Addiction Using Animal Models

Kuhn

Kalivas

Bobadilla

2019

Front. Behav. Neurosci.

119

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Drug addiction is a neuropsychiatric disorder with grave personal consequences that has an extraordinary global economic impact. Despite decades of research, the options available to treat addiction are often ineffective because our rudimentary understanding of drug-induced pathology in brain circuits and synaptic physiology inhibits the rational design of successful therapies. This understanding will arise first from animal models of addiction where experimentation at the level of circuits and molecular biology is possible. We will review the most common preclinical models of addictive behavior and discuss the advantages and disadvantages of each. This includes non-contingent models in which animals are passively exposed to rewarding substances, as well as widely used contingent models such as drug self-administration and relapse. For the latter, we elaborate on the different ways of mimicking craving and relapse, which include using acute stress, drug administration or exposure to cues and contexts previously paired with drug self-administration. We further describe paradigms where drug-taking is challenged by alternative rewards, such as appetitive foods or social interaction. In an attempt to better model the individual vulnerability to drug abuse that characterizes human addiction, the field has also established preclinical paradigms in which drug-induced behaviors are ranked by various criteria of drug use in the presence of negative consequences. Separation of more vulnerable animals according to these criteria, along with other innate predispositions including goal- or sign-tracking, sensation-seeking behavior or impulsivity, has established individual genetic susceptibilities to developing drug addiction and relapse vulnerability. We further examine current models of behavioral addictions such as gambling, a disorder included in the DSM-5, and exercise, mentioned in the DSM-5 but not included yet due to insufficient peer-reviewed evidence. Finally, after reviewing the face validity of the aforementioned models, we consider the most common standardized tests used by pharmaceutical companies to assess the addictive potential of a drug during clinical trials.

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Section: Individual Variation In Addiction-related Behaviorsmentioning

confidence: 99%

Understanding Addiction Using Animal Models

Kuhn

Kalivas

Bobadilla

2019

Front. Behav. Neurosci.

119

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“…Impulsivity reflects the lack of effective self-regulation or self-control in individuals and is correlated with general addictive behaviors (Di Nicola et al., 2010, 2015; Grant & Chamberlain, 2014; Mitchell & Potenza, 2014). For instance, groups of substance abusers including users of stimulants (e.g., cocaine and Benzedrine), opiates (e.g., heroin and morphine), and alcohol all exhibit high impulsivity (Belin et al., 2008; Coskunpinar et al., 2013; Moazen et al., 2018; Perry & Carroll, 2008).…”

Section: Introductionmentioning

confidence: 99%

Direct and Indirect Effects of Neuroticism on Internet Addiction in College Students: A Structure Equation Modeling Analysis

Zhang

2020

Psychol Rep

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In the recent decade, increased severity of Internet addiction has been the focus of considerable attention. This research aimed to explore the relationships between neuroticism and Internet addiction. A total of 459 undergraduate students in China participating in this study completed self-report measures of neuroticism, impulsivity, and Internet addiction. The results showed that neuroticism, impulsivity, and Internet addiction were significantly and positively correlated with one other. The structural equation modeling approach indicated that impulsivity, in part, mediated the effect of neuroticism on Internet addiction. An important indirect path from neuroticism to Internet addiction through impulsivity was exposed using the bootstrap method. The outcomes of previous studies were expounded on to define how neuroticism affects Internet addiction.

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“…In humans, greater preference for immediate monetary rewards and greater discounting of probabilistic gains and losses [60] is noted among individuals with opioid addictions relative to non-addicted individuals [61][62][63]-a preference which is exacerbated following mild opioid deprivation [64]. Preclinical models in rodents have demonstrated dose-dependent increases in delay discounting rates [65] and impulsive responding to the five-choice serial reaction time task [66] following morphine administration, while studies in mice have revealed reductions in motor impulsivity [67] and in perseverative responses to obtain reward [68] among MOR knockouts. Here, we observed the highest MOR BP ND among those at highest risk to misuse opioids and among those reporting the highest levels of impulsivity but, interestingly, we did not observe any relationships between PMQ scores and impulsivity.…”

Section: Discussionmentioning

confidence: 99%

Risk for opioid misuse in chronic pain patients is associated with endogenous opioid system dysregulation

et al. 2022

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Abstractµ-Opioid receptors (MOR) are a major target of endogenous and exogenous opioids, including opioid pain medications. The µ-opioid neurotransmitter system is heavily implicated in the pathophysiology of chronic pain and opioid use disorder and, as such, central measures of µ-opioid system functioning are increasingly being considered as putative biomarkers for risk to misuse opioids. To explore the relationship between MOR system function and risk for opioid misuse, 28 subjects with chronic nonspecific back pain completed a clinically validated measure of opioid misuse risk, the Pain Medication Questionnaire (PMQ), and were subsequently separated into high (PMQ > 21) and low (PMQ ≤ 21) opioid misuse risk groups. Chronic pain patients along with 15 control participants underwent two separate [11C]-carfentanil positron emission tomography scans to explore MOR functional measures: one at baseline and one during a sustained pain-stress challenge, with the difference between the two providing an indirect measure of stress-induced endogenous opioid release. We found that chronic pain participants at high risk for opioid misuse displayed higher baseline MOR availability within the right amygdala relative to those at low risk. By contrast, patients at low risk for opioid misuse showed less pain-induced activation of MOR-mediated, endogenous opioid neurotransmission in the nucleus accumbens. This study links human in vivo MOR system functional measures to the development of addictive disorders and provides novel evidence that MORs and µ-opioid system responsivity may underlie risk to misuse opioids among chronic pain patients.

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Adolescent morphine exposure induces immediate and long-term increases in impulsive behavior

Cited by 31 publications

References 68 publications

Understanding Addiction Using Animal Models

Understanding Addiction Using Animal Models

Direct and Indirect Effects of Neuroticism on Internet Addiction in College Students: A Structure Equation Modeling Analysis

Risk for opioid misuse in chronic pain patients is associated with endogenous opioid system dysregulation

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