Adolescent Jump Case in Japan Associated With Influenza but not Oseltamivir

Oseltamivir for treatment and prophylaxis of influenza infection

“…These behaviors have been associated with encephalitis, encephalopathy or without obvious CNS disease and have also been reported in children not exposed to NAIs [104,105,109]. The FDA reported 103 cases of neuropsychiatric symptoms in children taking oseltamivir (95 Japanese cases) whereas the WHO at present reported 140 episodes [106,109]. Symptoms typically have an abrupt onset and resolution, but in retrospective reviews it is unclear if these symptoms are related to underlying influenza infection or NAIs [105][106][107][108]109].…”

“…The FDA reported 103 cases of neuropsychiatric symptoms in children taking oseltamivir (95 Japanese cases) whereas the WHO at present reported 140 episodes [106,109]. Symptoms typically have an abrupt onset and resolution, but in retrospective reviews it is unclear if these symptoms are related to underlying influenza infection or NAIs [105][106][107][108]109]. Close monitoring of children with influenza regardless of treatment is recommended [35,48].…”

Postexposure Prophylaxis for Influenza in Pediatric Wards Oseltamivir or Zanamivir After Rapid Antigen Detection

“…Since the spring of 2007, oseltamivir has seldom been administered to adolescents with influenza except A(H1N1)pdm09, as the Japanese Ministry of Health, Labor and Welfare recommended that the administration of oseltamivir for influenza should be stopped in children and adolescents between 10 and 19 years of age because 15 fall/jump cases from buildings had been reported in Japan in patients of those ages who had received oseltamivir. 25 We tried to administer the drugs as soon as possible but some individuals received them more than 24 hours after contact with the febrile index case for at least 1 of the reasons mentioned in the subsequent non-PEP Group section. We administered PEP to the contacts regardless of their immunization status because young children and those with immunodeficiency may not have sufficient protective efficacy.…”

Oseltamivir Phosphate Induced Alterations in EEGs of Epilepsy-Prone El Mice

“…An 8-pin header was used to connect the electrodes to an electroencephalograph (EEG-8310; Nihon Kohden, Japan) with a band-pass at a time constant of 0.1 s, a 120 Hz low-pass filter, and a 50 Hz band elimination filter. The EEG was sampled with an A-D converter at 200 Hz and recorded with a digital data recorder (DR-M3b; TEAC, Japan) [3]. EEG waves were recorded for at least 1 hr once per day for 3 to 7 days and analyzed with Pc-Wave Form software (DEICY, Tokyo, Japan).…”

“…Kenichi SAITO 1 , Shinya KOIZUMI 2 and Yasuhiko KAWAKAMI 3 Oseltamivir phosphate (Tamiflu) is an antiviral drug used to treat patients with influenza [1,2]. Several deaths, however, have been reported in Japanese children treated with oseltamivir.…”