Adolescent girls’ neural response to reward mediates the relation between childhood financial disadvantage and depression

Romens, Sarah E.; Casement, Melynda D.; McAloon, Rose; Keenan, Kate; Hipwell, Alison E.; Guyer, Amanda E.; Forbes, Erika E.

doi:10.1111/jcpp.12410

Cited by 53 publications

(60 citation statements)

References 40 publications

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“…The reward network is altered in adolescents with depressive disorder (Forbes & Dahl, ; Kerestes et al., b; Romens et al., ) and also in unaffected first‐degree relatives of patients with depression (Olino et al., ). One of the most prominent findings is that of reduced anticipation for reward.…”

Section: Depressionmentioning

confidence: 99%

Annual Research Review: Transdiagnostic neuroscience of child and adolescent mental disorders – differentiating decision making in attention‐deficit/hyperactivity disorder, conduct disorder, depression, and anxiety

Sonuga‐Barke

Cortese

Fairchild

et al. 2015

Child Psychology Psychiatry

139

119

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BackgroundIneffective decision making is a major source of everyday functional impairment and reduced quality of life for young people with mental disorders. However, very little is known about what distinguishes decision making by individuals with different disorders or the neuropsychological processes or brain systems underlying these. This is the focus of the current review.Scope and methodologyWe first propose a neuroeconomic model of the decision‐making process with separate stages for the prechoice evaluation of expected utility of future options; choice execution and postchoice management; the appraisal of outcome against expectation; and the updating of value estimates to guide future decisions. According to the proposed model, decision making is mediated by neuropsychological processes operating within three domains: (a) self‐referential processes involved in autobiographical reflection on past, and prospection about future, experiences; (b) executive functions, such as working memory, inhibition, and planning, that regulate the implementation of decisions; and (c) processes involved in value estimation and outcome appraisal and learning. These processes are underpinned by the interplay of multiple brain networks, especially medial and lateralized cortical components of the default mode network, dorsal corticostriatal circuits underpinning higher order cognitive and behavioral control, and ventral frontostriatal circuits, connecting to brain regions implicated in emotion processing, that control valuation and learning processes.Findings and conclusionBased on clinical insights and considering each of the decision‐making stages in turn, we outline disorder‐specific hypotheses about impaired decision making in four childhood disorders: attention‐deficit/hyperactivity disorder (ADHD), conduct disorder (CD), depression, and anxiety. We hypothesize that decision making in ADHD is deficient (i.e. inefficient, insufficiently reflective, and inconsistent) and impulsive (biased toward immediate over delayed alternatives). In CD, it is reckless and insensitive to negative consequences. In depression, it is disengaged, perseverative, and pessimistic, while in anxiety, it is hesitant, risk‐averse, and self‐deprecating. A survey of current empirical indications related to these disorder‐specific hypotheses highlights the limited and fragmentary nature of the evidence base and illustrates the need for a major research initiative in decision making in childhood disorders. The final section highlights a number of important additional general themes that need to be considered in future research.

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Section: Depressionmentioning

confidence: 99%

Annual Research Review: Transdiagnostic neuroscience of child and adolescent mental disorders – differentiating decision making in attention‐deficit/hyperactivity disorder, conduct disorder, depression, and anxiety

Sonuga‐Barke

Cortese

Fairchild

et al. 2015

Child Psychology Psychiatry

139

119

View full text Add to dashboard Cite

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“…In addition, future experiments should examine the specific home lives of PCE children in more detail and assess stressful life events to determine if differences seen in this population are a result of exposure or of environmental factors that accompany such exposure. There were no differences in SES between the NCE and PCE samples in this cohort, but environmental differences may nonetheless exist, and effects of low SES and high stress environments play prominent roles in reward processing (Romens et al, 2015). …”

Section: Discussionmentioning

confidence: 91%

Feedback processing in adolescents with prenatal cocaine exposure: an electrophysiological investigation

Morie

Landi

et al. 2018

Developmental Neuropsychology

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Impaired cognitive control is a consequence of cocaine exposure. Difficulty with feedback processing may underlie this impairment. We examined neural correlates of feedback processing using event-related potentials (ERPs) in 49 prenatally cocaine-exposed (PCE) and 34 nondrug exposed (NDE) adolescents. Adolescents performed a reward-feedback task with win/no-win feedback in a chance-based task. We investigated amplitude and latency of the feedback-related negativity (FRN) and P300 ERP components and source-based estimates elicited during feedback processing. PCE adolescents had smaller P300 amplitudes for no-win feedback, and source analysis in the P300 time window revealed differences between groups localized to the dorsal anterior cingulate cortex.

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“…Finally, our findings should be interpreted with caution in generalizing to other populations, particularly women and men not living in low-income, urban environments. Participants in this sample have been exposed to a high level of acute and chronic stressors, which may affect their frontostriatal reactivity during reward processing (73, 74). Thus, follow-up studies are needed to examine how individual differences in life experiences may lead to individual differences in reward-related neural reactivity.…”

Section: Discussionmentioning

confidence: 99%

Reward-Related Neural Correlates of Antisocial Behavior and Callous–Unemotional Traits in Young Men

Murray

Shaw

Forbes

et al. 2017

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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Background Individuals involved in antisocial behavior often engage in excessive reward-driven behavior even in the face of severe punishments including incarceration. However, the neural mechanisms of reward processing in antisocial behavior have not been examined while considering the heterogeneity of antisocial behavior and specific phases of reward and loss processing. In this study, we investigate the relationship between antisocial behavior, callous-unemotional traits, and neural activity during the anticipation and receipt of rewards and losses. Methods A community sample of 144 low income, racially diverse, urban males at risk for antisocial behavior completed self-report measures, a clinical interview, and an fMRI scan at age 20. Neural response during the anticipation and receipt of monetary rewards and losses was linked to antisocial behavior and callous-unemotional traits using a priori ventral striatum region of interest analyses and exploratory whole brain analyses. Results Antisocial behavior, but not callous-unemotional traits, was related to less ventral striatum response during reward anticipation. There were no significant relationships between neural reactivity and antisocial behavior or callous-unemotional traits during reward or loss outcomes. Antisocial behavior was also related to less ventrolateral prefrontal cortex reactivity during reward and loss anticipation. Conclusions These findings support a hypo-reactivity model of reward and loss anticipation in antisocial behavior. Lower striatal reactivity to cues of reward and lower prefrontal-regulatory recruitment during reward and loss anticipation may contribute to maladaptive reward-related behavior found in antisocial behavior.

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Adolescent girls’ neural response to reward mediates the relation between childhood financial disadvantage and depression

Cited by 53 publications

References 40 publications

Annual Research Review: Transdiagnostic neuroscience of child and adolescent mental disorders – differentiating decision making in attention‐deficit/hyperactivity disorder, conduct disorder, depression, and anxiety

Annual Research Review: Transdiagnostic neuroscience of child and adolescent mental disorders – differentiating decision making in attention‐deficit/hyperactivity disorder, conduct disorder, depression, and anxiety

Feedback processing in adolescents with prenatal cocaine exposure: an electrophysiological investigation

Reward-Related Neural Correlates of Antisocial Behavior and Callous–Unemotional Traits in Young Men

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