Adolescent Ethanol Sensitivity: Hypothermia and Acute Tolerance

Ristuccia, Robert C.; Spear, Linda P.

doi:10.1196/annals.1308.061

Cited by 22 publications

(24 citation statements)

References 10 publications

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“…However the successful manual collection of data has been dependent on the co-operation or training of the animal to orient itself to the operator, and can be subject to interference, for example from the metal bars of the home cage. The automated collection of physiological data has been reported in the study of animal welfare in small laboratory animals (Kramer and Kinter, 2003;Savage, 2004) and also applied to the detection of myoelectric activity in the pig duodenum (Ristuccia and Spear, 2004) and hypothermia in rats (Yaa et al, 2004). We have taken this approach further in the current study by establishing the automated collection of data from the remote monitoring of Tc in individual infected mice group-housed in biocontainment.…”

Section: Introductionmentioning

confidence: 99%

A biocompatible microdevice for core body temperature monitoring in the early diagnosis of infectious disease

Williamson

Savage

Lingard

et al. 2006

Biomed Microdevices

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The early diagnosis of microbial infection is critical to the clinical instigation of effective post-exposure prophylaxis or therapy. However, diagnosis of infection is often attempted only when there are overt clinical signs, and for some of the serious human pathogens, this may jeopardize the efficacy of therapy. We have used a miniaturised sealed, implantable transponder incorporating a calibrated temperature sensor with an external receiver system, to monitor core body temperature (Tc) remotely. We have observed early changes in the diurnal rhythm of Tc, after infection of mice with bacterial pathogens. Changes in Tc preceded overt clinical signs by 3-10 h following challenge with Yersinia pestis, which causes acute infection, In contrast, changes in Tc were detected 11 days before clinical signs in mice exposed to Burkholderia pseudomallei, which causes a chronic syndrome. Significantly, mice pre-vaccinated against Y.pestis infection showed only slight and transient disruption to the diurnal rhythm for Tc, in the absence of clinical signs, when challenged with 10(6) median lethal doses of Y.pestis. This remote monitoring technology could be used to monitor changes in more than one physiological parameter and extrapolation of these data to the clinic would define the available therapeutic window in which diagnosis and post-exposure prophylaxis could be instigated, after a suspected exposure.

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Section: Introductionmentioning

confidence: 99%

A biocompatible microdevice for core body temperature monitoring in the early diagnosis of infectious disease

Williamson

Savage

Lingard

et al. 2006

Biomed Microdevices

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show abstract

“…Some studies have found adolescent rats to exhibit less hypothermia than mature animals following injected or intubated ethanol (Ristuccia and Spear, 2004;Silveri and Spear, 2000). Brasser and Spear (2002) also found adolescents to show less ethanol-induced hypothermia than adult rats following intragastric (i.g.)…”

mentioning

confidence: 97%

“…However, in Silveri and Spear (2000), ethanol was injected intraperitoneally (i.p.) and temperatures were taken with a rectal probe, whereas Brasser and Spear (2002) and Ristuccia and Spear (2004) intubated the animals i.g. even though temperatures were recorded using telemetry probes.…”

mentioning

confidence: 99%

Differential Expression of Ethanol‐Induced Hypothermia in Adolescent and Adult Rats Induced by Pretest Familiarization to the Handling/Injection Procedure

Ristuccia

Hernandez

Wilmouth

et al. 2007

Alcoholism Clin & Exp Res

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Observed differences between adolescents and adults in the autonomic consequences of ethanol were dramatically influenced by whether animals were familiarized with the handling/injection process before testing. Under these circumstances, adolescents were less susceptible than adults to the impact of experimental perturbation on ethanol-induced hypothermia. These findings suggest that seemingly innocuous aspects of experimental design can influence conclusions reached on ontogenetic differences in sensitivity to ethanol, at least when indexed by ethanol-induced hypothermia.

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“…Early adolescents were also less sensitive than late adolescents to the anxiolytic effects of ethanol revealed in the unfamiliar test situation, when indexed in terms of increases in social investigation and the ethanol-induced transformation of social avoidance into social preference. Several physiological differences emerge, adult rats displayed more rapid, and prolonged ethanol-induced hypothermia than adolescent rats (Ristuccia and Spear 2004). Several converging studies have demonstrated that, in the laboratory, adolescent animals were found to be less sensitive than adult animals to the various different effects of ethanol available functionally as cues to limit intake, including effects evident during intoxication (e.g., ethanolinduced motor impairment, anxiolysis, social impairment, and sedation), as well as during the post-intoxication period (e.g., ''hangover''-associated anxiogenesis).…”

Section: Neurodevelopmental Staging In Adolescencementioning

confidence: 98%

Staging Perspectives in Neurodevelopmental Aspects of Neuropsychiatry: Agents, Phases and Ages at Expression

et al. 2010

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Neurodevelopmental risk factors have assumed a critical role in prevailing notions concerning the etiopathogenesis of neuropsychiatric disorders. Staging, diagnostic elements at which phase of disease is determined, provides a means of conceptualizing the degree and extent of factors affecting brain development trajectories, but is concurrently specified through the particular interactions of genes and environment unique to each individual case. For present purposes, staging perspectives in neurodevelopmental aspects of the disease processes are considered from conditions giving rise to neurodevelopmental staging in affective states, adolescence, dopamine disease states, and autism spectrum disorders. Three major aspects influencing the eventual course of individual developmental trajectories appear to possess an essential determinant influence upon outcome: (i) the type of agent that interferes with brain development, whether chemical, immune system activating or absent (anoxia/hypoxia), (ii) the phase of brain development at which the agent exerts disruption, whether prenatal, postnatal, or adolescent, and (iii) the age of expression of structural and functional abnormalities. Clinical staging may be assumed at any or each developmental phase. The present perspective offers both a challenge to bring further order to diagnosis, intervention, and prognosis and a statement regarding the extreme complexities and interwoven intricacies of epigenetic factors, biomarkers, and neurobehavioral entities that aggravate currents notions of the neuropsychiatric disorders.

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Adolescent Ethanol Sensitivity: Hypothermia and Acute Tolerance

Cited by 22 publications

References 10 publications

A biocompatible microdevice for core body temperature monitoring in the early diagnosis of infectious disease

A biocompatible microdevice for core body temperature monitoring in the early diagnosis of infectious disease

Differential Expression of Ethanol‐Induced Hypothermia in Adolescent and Adult Rats Induced by Pretest Familiarization to the Handling/Injection Procedure

Staging Perspectives in Neurodevelopmental Aspects of Neuropsychiatry: Agents, Phases and Ages at Expression

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