Adolescent chronic escalating morphine administration induces long lasting changes in tolerance and dependence to morphine in rats

Salmanzadeh, Hamed; Azizi, Hossein; Semnanian, Saeed

doi:10.1016/j.physbeh.2017.03.014

Cited by 28 publications

(17 citation statements)

References 52 publications

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“…In a study on long-term effect of morphine exposure during adolescence and adulthood on morphine locomotor sensitization, it was demonstrated that adolescent morphine-exposed rats exhibited morphine sensitization in response to a single dose of morphine injection after five weeks of abstinence while adult morphine-exposed rats did not demonstrate morphine sensitization in the same paradigm (Koek, 2014;White & Holtzman, 2005). We have also observed in our laboratory that morphine exposure during adolescence facilitates development of morphine tolerance and dependency (Salmanzadeh et al, 2017). The difference in long-term effect of response to morphine (current finding and the aforementioned studies) reflects the fact that different signaling pathways and anatomical regions are involved in morphine analgesia, sensitization, tolerance, and dependency.…”

Section: Discussionmentioning

confidence: 57%

“…Our previous findings revealed that by administration of escalating doses of morphine between PNDs 31 and 40 in male rats, the development of morphine tolerance and morphine dependency increases in the adulthood (Salmanzadeh, Azizi, & Semnanian, ). Furthermore, our findings demonstrated that the baseline activity of LPGi neurons, a nucleus which is involved in mediating opiate effects in the brain (Ahmadi‐Soleimani, Azizi, Gompf, & Semnanian, ; Ahmadi‐Soleimani, Ghaemi‐Jandabi, Azizi, & Semnanian, ; Ghaemi‐Jandabi, Azizi, & Semnanian, ; Kaeidi et al, ), was enhanced in adolescent morphine‐treated animals during adulthood (Salmanzadeh, Azizi, Soleimani, Pachenari, & Semnanian, ).…”

Section: Introductionmentioning

confidence: 99%

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Adolescent morphine exposure increases nociceptive behaviors in rat model of formalin test

Ghasemi

Pachenari

Semnanian

et al. 2018

Developmental Psychobiology

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The number of adolescents who use illicit drugs has increased dramatically. Adolescence is a critical period for brain development and maturation. The importance of the study of pain perception and the possible mechanisms involved is crystal clear. Up until now, there has been no evidence regarding the long‐term effect of adolescence morphine administration on pain perception. The objective of the present study was to investigate long‐lasting effect of adolescent morphine exposure on pain perception as well as analgesic response to a single dose of morphine injection. Adolescent and adult rats received morphine or saline, and then after 30 days of washout period, formalin test was performed. To evaluate morphine analgesia, in a separate group of animals, formalin test was performed after injection of a single dose of morphine during adulthood. The results demonstrated that the adolescent rats treated by morphine exhibited higher pain‐related behaviors compared to the control group, while the same results were not observed in adult rats that had been treated by morphine. Moreover, there was no significant difference in analgesic response to a single dose of morphine between two experimental groups. This study demonstrates enduring effect of morphine exposure during adolescence on pain perception.

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Section: Discussionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Adolescent morphine exposure increases nociceptive behaviors in rat model of formalin test

Ghasemi

Pachenari

Semnanian

et al. 2018

Developmental Psychobiology

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“…Among these are that it might diminish morphine's undesirable side effects. These include tolerance and dependence (Cowan and Macfarlane, 1975;Nozaki et al, 1975;Hasanein et al, 2015;Salmanzadeh et al, 2017), inhibition of gastrointestinal motility (Niwa et al, 2002;Gallantine and Meert, 2008), and respiratory depression (Emery et al, 2016;Whiteside et al, 2016). These preceding reports show that these adverse effects of morphine are dose dependent, and that the doses of morphine used in the present studies in combination with CRAs are sufficiently low that they would have the possibility of obviating the development of at least some of these adverse effects.…”

Section: Discussionmentioning

confidence: 64%

Coadministration of Chemokine Receptor Antagonists with Morphine Potentiates Morphine’s Analgesic Effect on Incisional Pain in Rats

Inan

Eisenstein

Watson

et al. 2018

J Pharmacol Exp Ther

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Crossdesensitization between opioid and chemokine receptors and involvement of chemokines in pain modulation are well established. We investigated if coadministration of chemokine receptor antagonists (CRAs) with morphine would enhance the analgesic potency of morphine on incisional pain in rats. Animals underwent incisional surgery on the left hind paw and pain responses were evaluated using von Frey filaments at various time points postsurgery between 15 and 360 minutes and daily between 24 and 72 hours. Dose-response curves for morphine, maraviroc (a CCR5 antagonist), and AMD3100 (a CXCR4 antagonist) alone were established. While morphine significantly reduced pain in a time-and dose-dependent manner, maraviroc and AMD3100 had no effect by themselves. Coadministration of either maraviroc or AMD3100 with morphine significantly increased morphine's analgesic effect on incisional pain, shifting the dose-response curve to the left 2.3and 1.8-fold, respectively. Coadministration of both CRAs with morphine significantly shifted further the morphine doseresponse curve to the left 3.3-fold. The effect of treatments on mRNA levels in the draining popliteal lymph node for a panel of chemokines and cytokines showed that message for many of these mediators was upregulated by the incision, and the combination of morphine with the CRAs markedly downregulated them. The data show that combining morphine with CRAs potentiates morphine's analgesic effect on incisional pain. Thus, the same analgesic effect of morphine alone can be achieved with lower doses of morphine when combined with CRAs. Using morphine in lower doses could reduce unwanted side effects and possibly block development of tolerance and dependence.

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“…All injections were subcutaneous and were administered twice daily (8:00 a.m. and 5:00 p.m.). The morphine group in accordance with past studies received increasing morphine doses (2.5, 5, 7.5, 10, 12.5, 15, 17.5, 20, 22.5, 25 mg/kg) (Khani et al., 2022; Salmanzadeh et al., 2017; Salmanzadeh et al., 2018). After a 7‐days drug‐free period, the open field test (OFT) for detecting locomotor activity (PND 48, PND 56, PND 64, and PND 72) and elevated plus maze (EPM) test to identify anxiety‐like behavior (PND 49, PND 57, PND 65, and PND 73) were performed over a 4‐week postmorphine period from adolescence to adulthood.…”

Section: Methodsmentioning

confidence: 93%

Development of anxiety‐like behaviors during adolescence: Persistent effects of adolescent morphine exposure in male rats

Khani

Pourmotabbed

Hosseinmardi

et al. 2022

Developmental Psychobiology

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Epidemiological studies show the prevalence of opioid use, misuse and abuse in adolescents, which imposes social and economic accountability worldwide. Chronic opioid exposure, especially in adolescents, may have lasting effects on emotional behaviors that persist into adulthood. The current experiments were therefore designed to study the effects of sustained opioid exposure during adolescence on anxiety-like behaviors. Adolescent male Wistar rats underwent increasing doses of morphine for 10 days (PNDs 31-40). After that the open field test (OFT) and elevated plus maze (EPM) test were performed over a 4-week postmorphine treatment from adolescence to adulthood. Moreover, the weight of the animals was measured at these time points. We found that chronic adolescent morphine exposure reduces the weight gain during the period of morphine treatment and 4 weeks after that. It had no significant effect on the locomotor activity in the animals. Moreover, anxiolytic-like behavior was observed in the rats exposed to morphine during adolescence evaluated by OFT and EPM test.Thus, long-term exposure to morphine during adolescence has the profound potential of altering the anxiety-like behavior profile in the period from adolescence to adulthood. The maturation of the nervous system can be affected by drug abuse during the developmental window of adolescence and these effects may lead to behaviorally stable alterations.

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Adolescent chronic escalating morphine administration induces long lasting changes in tolerance and dependence to morphine in rats

Cited by 28 publications

References 52 publications

Adolescent morphine exposure increases nociceptive behaviors in rat model of formalin test

Adolescent morphine exposure increases nociceptive behaviors in rat model of formalin test

Coadministration of Chemokine Receptor Antagonists with Morphine Potentiates Morphine’s Analgesic Effect on Incisional Pain in Rats

Development of anxiety‐like behaviors during adolescence: Persistent effects of adolescent morphine exposure in male rats

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