Adolescent Cardiovascular Functional and Structural Outcomes of Growth Trajectories from Infancy: Prospective Community-Based Study

Hanvey, Alanna N.; Mensah, Fiona; Clifford, Susan A; Wake, Melissa

doi:10.1089/chi.2016.0263

Cited by 19 publications

(32 citation statements)

References 41 publications

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“…Almost half (45%) of the adolescents in this study had a classification of overweight/obese, consistent with the national average among African-American adolescents (1). BMI trajectories during childhood are strongly associated with cardiovascular risks, above and beyond BMI at any given point in time in childhood (2). The mid-teen years may "represent a 'tipping point' after which the vascular system no longer adapts to childhood adiposity and readily measurable vascular damage begins to occur."…”

Section: Discussionsupporting

confidence: 75%

“…BMI trajectories during childhood are strongly associated with cardiovascular risks, above and beyond BMI at any given point in time in childhood . The mid‐teen years may “represent a ‘tipping point’ after which the vascular system no longer adapts to childhood adiposity and readily measurable vascular damage begins to occur.” Adolescence is characterized by relative immaturity of the frontally mediated cognitive control system which is vital to the inhibition of impulsive responses and to decision‐making based on environmental stimuli . Underdeveloped inhibitory skills combined with greater autonomy over food choices in adolescence pose a risk for weight gain during this critical time.…”

Section: Discussionmentioning

confidence: 99%

“…Excess weight gain during childhood is a major determinant of young adult obesity. Increases in rate of weight gain have the potential to increase subsequent obesity-related health risks in young adults (2). Impaired self-regulation has been implicated in excess weight gain among children (3,4).…”

mentioning

confidence: 99%

“…No association is expected in the group with PDE. (2) The association between cortisol reactivity and BMI z-score change varies by gender, with increased cortisol reactivity predictive of greater BMI z-score change (over 1 year) for girls, not boys. (3) There is a conditional indirect effect of cortisol reactivity on the association between inhibition and BMI z-score change.…”

mentioning

confidence: 99%

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Cortisol reactivity and weight gain among adolescents who vary in prenatal drug exposure

2018

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Cortisol reactivity and weight gain among adolescents who vary in prenatal drug exposure

2018

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“…Recent studies have looked at trajectory groups of BMI with different numbers and profiles of trajectories over childhood including early childhood 1,8 and later childhood through to adolescence. 25,26 Two studies have followed a cohort from birth to age 14 years with focus on 1 outcome [27][28][29] as distinct from our study of a wide number of cardiometabolic markers.…”

Section: Discussionmentioning

confidence: 99%

Weight Gain Trajectories from Birth to Adolescence and Cardiometabolic Status in Adolescence

Barraclough

Garden

Toelle

et al. 2019

The Journal of Pediatrics

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Objective To assess the influence of the trajectory of weight gain from birth to adolescence on cardiovascular and metabolic risk. We studied childhood body mass index (BMI) trajectories from birth to age 14 years and cardiometabolic risk factors at age 14 years. Study design In total, 410 children with weight and height measurements were assessed from birth throughout childhood, from the Childhood Asthma Prevention Study, a prospective community-based cohort. BMI trajectory groups were determined by latent basis growth mixture models. Of these subjects, 190 had detailed cardiometabolic risk factors assessed at age 14 years. Results Three BMI trajectory groups were identified; normal BMI, "early rising" excess BMI from 2 years, and "late rising" excess BMI from 5 years. Differences were found between normal and excess BMI in children at 14 years of age. In addition, children with an early rising BMI trajectory had statistically significantly higher central adiposity and a more atherogenic lipoprotein profile at age 14 years than children with a late rising BMI trajectory (P < .05). No differences between BMI trajectory groups in vascular structure or function was identified at age 14 years. Conclusions Earlier onset of an elevated BMI trajectory persisting from birth to age 14 years results in an unfavorable cardiometabolic risk profile at age 14 years, including central adiposity and more atherogenic lipoproteins, independent of achieved BMI.

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Childhood BMI trajectories predict cardiometabolic risk and perceived stress at age 13 years: the STARS cohort

Chen,

Dangardt,

Gelander

et al. 2023

Obesity

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ObjectiveThe aim of this study was to examine BMI trajectories from birth throughout childhood, associations with health outcomes at age 13 years, and time frames during which early‐life BMI influenced adolescent health.MethodsParticipants (1902, 44% male) reported perceived stress and psychosomatic symptoms and were examined for waist circumference (WC), systolic blood pressure (SBP), pulse wave velocity, and white blood cell counts (WBC). BMI trajectory was analyzed using group‐based trajectory modeling of retrospective data of weight/height from birth throughout childhood. The authors performed linear regression to assess associations between BMI trajectories and health outcomes at age 13 years, presented as estimated mean differences with 95% CI among trajectories.ResultsThree BMI trajectories were identified: normal; moderate; and excessive gain. Adjusting for covariates, adolescents with excessive gain had higher WC (19.2 [95% CI: 18.4–20.0] cm), SBP (3.6 [95% CI: 2.4–4.4] mm Hg), WBC (0.7 [95% CI: 0.4–0.9] × 109/L), and stress (1.1 [95% CI: 0.2–1.9]) than adolescents with normal gain. Higher WC (6.4 [95% CI: 5.8–6.9] cm), SBP (1.8 [95% CI: 1.0–2.5] mm Hg), and stress (0.7 [95% CI: 0.1–1.2]) were found in adolescents with moderate versus normal gain. The association of early‐life BMI with SBP started around age 6 years with the excessive gain group, which was earlier than in the normal and moderate gain groups, in which it started at age 12 years.ConclusionsAn excessive gain BMI trajectory from birth predicts cardiometabolic risk and stress in 13‐year‐old individuals.

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Adolescent Cardiovascular Functional and Structural Outcomes of Growth Trajectories from Infancy: Prospective Community-Based Study

Cited by 19 publications

References 41 publications

Cortisol reactivity and weight gain among adolescents who vary in prenatal drug exposure

Cortisol reactivity and weight gain among adolescents who vary in prenatal drug exposure

Weight Gain Trajectories from Birth to Adolescence and Cardiometabolic Status in Adolescence

Childhood BMI trajectories predict cardiometabolic risk and perceived stress at age 13 years: the STARS cohort

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