Admixture and genetic relationships of Mexican Mestizos regarding Latin American and Caribbean populations based on 13 CODIS-STRs

Abstract

Short tandem repeats (STRs) of the combined DNA index system (CODIS) are probably the most employed markers for human identification purposes. STR databases generated to interpret DNA profiles are also helpful for anthropological purposes. In this work,

Characterisation of genetic structure of the Mayan population in Guatemala by autosomal STR analysis

“…Many groups have described the genetic background of the Mestizo population in Latin America (Martinez-Espin et al, 2006;Salazar-Flores et al, 2015). Recent studies show that STR analysis of the Guatemalan Mestizo population has revealed an elevated Amerindian ancestry.…”

“…Recent studies show that STR analysis of the Guatemalan Mestizo population has revealed an elevated Amerindian ancestry. However, the ancestral pool used for these comparisons was comprised of Mexican Amerindians (Salazar-Flores et al, 2015).…”

Analysis of fortuitous matches in a STR genotype database from Mexico and its forensic efficiency parameters

“…In brief, based on the PowerPlex 16 system, our results support a relative homogeneity among Mexican populations from the Central region, excluding the Western region from this cluster. This conclusion applies to Mestizos (admixed), who constitute the largest proportion of the Mexican population (~90%) (Rubi-Castellanos et al 2009;Salazar-Flores et al 2015), but is invalid for Native American groups, who display a particular genetic structure ). The genetic structure described herein is important in forensic casework because it allows geneticists using alternative STR population data, given that most of the Mexican populations do not have their own STR databases.…”

“…In 2011, the federal State of Mexico (located within the Central region, Mexico) established a civil and criminal STR database containing approximately 2000 DNA profiles analyzed with the commercial PowerPlex 16 System (Krenke et al 2002). Although many Mexican populations have been analyzed with autosomal STRs to support forensic casework (Rubi-Castellanos et al 2009;Salazar-Flores et al 2015), only the following states/regions of the country have been studied with the PowerPlex 16 kit: Guanajuato, Veracruz, Nayarit, Yucatan, Mexico City, and the Western region (Rangel-Villalobos et al 2010;González-Herrera et al 2010;Ramírez-Flores et al 2014;Martínez-Sevilla et al 2016). Furthermore, the population structure and genetic relationships of the Mexican populations remain unexplored using PowerPlex 16 System.…”

Statistical Parameters of Forensic Importance for 15 Autosomal STRs in Mestizo Population from the State of Guerrero (South Mexico)

“…Many studies have been conducted in Mexican-Mestizos to validate the application of autosomal short tandem repeats (STRs) for human identification purposes. 1,2 However, in Mexico, this forensic validation requires the study of different populations, given the genetic structure demonstrated among Mestizos from different regions. 3 Based on the 13 STRs of the Combined DNA Index System (CODIS), it has been claimed that the European ancestry increases gradually towards the Northwestern region and diminishes towards the Central and Southeastern regions; conversely, the Amerindian ancestry displays an opposite pattern increasing towards the Central and Southeastern region, and decreasing towards the Northwestern region.…”