Admission hyponatraemia as heart failure events predictor in patients with acute heart failure

Sarastri, Yuke; Zebua, Juang Idaman; Lubis, Puja Nastia; Zahra, Fathi; Lubis, Anggia Chairuddin

doi:10.1002/ehf2.14472

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…Результати, зіставні з нашими даними, наведено в дослідженні HARVEST, де оцінювали прогностичну роль вмісту натрію при госпіталізації, протягом 90-денного періоду, а також вивчали чотирирічну виживаність хворих на гостру серцеву недостатність. Доведено роль гіпонатріємії як значущого предиктора серцево-судинної смертності (ВР = 1,76; 95% ДІ: 1,39-2,23, р < 0,001 ), а також загальної смертності (ВР = 1,64; 95 % ДІ: 1,40-1,93, р < 0,001) у цих пацієнтів [28].…”

Section: оригінальні дослідженняunclassified

The impact of renal tubulointerstitial dysfunction on the early and long-term prognosis in chronic heart failure patients with preserved left ventricular ejection fraction

Syvolap,

Lysenko,

Svitlyi

2024

Pathologia

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Aim. To study the dependence of the early-term (1 year) and long-term (5 years) prognosis in patients with chronic heart failure (CHF) of ischemic origin with preserved left ventricular ejection fraction (LVEF) depending on renal tubulointerstitial functional disorders. Materials and methods. The study involved 88 patients (men – 46.6 % (n = 41); women – 53.4 % (n = 47)) with CHF of ischemic origin, stage II A–B, stage II–IV according to NYHA, 67 % (n = 59) with sinus rhythm, and 33 % (n = 29) with atrial fibrillation. Patients with sinus rhythm and atrial fibrillation were matched in age (p = 0.483), height (p = 0.345), weight (p = 0.317), body surface area (p = 0.153). NGAL levels were analyzed using an ELISA kit (E-EL-H0096, Elabscience, USA). NAG levels were analyzed using an ELISA kit (SEA 069 Hu, Cloud-Clone Corp., USA). KIM-1 levels were analyzed using an ELISA kit (SEA 785 Hu, Cloud-Clone Corp., USA). Kaplan–Meier curves and Cox proportional hazards regression analysis were performed. Results. No significant difference was found in the frequency of the cumulative endpoint during the first-year follow-up from the initial level of two markers of tubulointerstitial injury – KIM-1 (Log-Rank Test: p = 0.57529) and NAG (Log-Rank Test: p = 0.86001). According to the results of analysis of the Cox proportional hazards, only a tendency to increase in the risk factors of adverse events were observed in case of elevated KIM-1 (HR = 1.66; p = 0.5795) and NAG levels (HR = 1.1712; p = 0.8626) in this CHF patients’ cohort. Kaplan–Meier analysis revealed a probable (Log-Rank Test; p = 0.00141) increase in the frequency of the cumulative endpoint during the first year of follow-up in CHF patients with preserved LVEF due to increased serum NGAL level more than 168 ng/ml. According to the univariate model, an elevated serum NGAL level is associated with an increase in the relative risk by 4.2 times (95 % CI 1.78–16.89; p = 0.014). A reduced sodium level less than 142.5 mmol/l was associated with an increase in number of adverse cardiovascular events during the first-year follow- ups by 22 % (HR = 1.22, p = 0.029). After 5 years of follow-up, a decrease in sodium level less than 142.3 mmol/l is also characterized by a probable difference of the cumulative Kaplan–Meier’s curves (Cox–Mantel F-Test, p = 0.00287). According to the univariate model of Cox proportional hazards, the relative risk of adverse cardiovascular events in patients with CHF during the 5-year follow-up has a tendency to increase by 1.04 times (95 % CI 0.85–1.27; p = 0.72). Serum NGAL, a marker of renal tubulo-interstitial injury, doesn’t lose its properties as a powerful marker of an unfavorable long-term prognosis in patients with CHF with preserved LVEF (HR = 5.96; 95 % CI 1.17–30.50; p = 0.032). Conclusions. The most powerful factors of the early (1-year) prognosis of adverse cardiovascular events in CHF patients with preserved left ventricular ejection fraction are the marker of tubulointerstitial injury, serum NGAL over 168 ng/ml, as well as the marker of tubulointerstitial dysfunction – the serum sodium level less than 142.5 mmol/l. The electrolyte imbalance, decreased sodium level less than 142.3 mmol/l, remains a powerful marker of an unfavorable long-term 5-year prognosis in CHF patients with preserved left ventricular ejection fraction, meanwhile serum NGAL, a marker of renal tubulointerstitial injury, besides doesn’t lose its prognostic value (HR = 5.96; 95 % CI 1.17–30.50; p = 0.032), but also is independent from the parameters of the age (p = 0.409) and gender (p = 0.397) in such patients.

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Section: оригінальні дослідженняunclassified

The impact of renal tubulointerstitial dysfunction on the early and long-term prognosis in chronic heart failure patients with preserved left ventricular ejection fraction

Syvolap,

Lysenko,

Svitlyi

2024

Pathologia

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“…Heart failure is a prevalent issue that shows no signs of abating (Sarastri et al, 2023). About half of people who experience heart failure die within five years after being diagnosed.…”

Section: Introductionmentioning

confidence: 99%

Self Care Behavior among Patients with Heart Failure in Hasan Sadikin General Hospital Bandung Indonesia

Istianah,

Binti Mohd Said,

Nambiar

et al. 2023

MJN

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Background: Self-care behavior is crucial for patients with heart failure to have positive outcomes, and it also serves as a predictor of wellbeing. The self-care tasks that these patients are required to carry out include managing their symptoms, sticking to numerous pharmaceutical regimens, following dietary salt restrictions, and self-monitoring weight. In many cases, a crucial aspect of heart failure treatment is still challenging. Objective: To determine the self-care practices of patients with heart failure at Hasan Sadikin General Hospital in Bandung, Indonesia. Methods: The study used a descriptive study with a consecutive sampling of 196 patients with heart failure in the clinic. Results: the demographic characteristics were mean of age (in year) 56.26 ± 12.49, majority were male 144 respondents (73.57%), above the senior high school 128 respondents (65.3%), New York Heart Association NYHA II category 76 respondents (38.8%), NYHA III category at 92(46.9%), NYHA IV category at 28(14.3%), EF 33.65±9.311, length of HF 2.02± 1.08, BMI 25.48±1.98, total score of self-care behaviour 88.35±7.736. The score of the subvariable of self-care behavior is as follows: consulting behaviors 19.68±2.405, dietary behaviors 8.16 ± 1.207, symptom perception 21.93 ±2.188, symptom recognition 9.65 ±1.393, self-care management 8.64±0.853, problem-solving behaviors 4.64±1.278, self-efficacy 20.20 ±1.979. Conclusion: Patients with heart failure exhibit poor self-care behavior; hence, nurse practitioners' involvement is required to promote self-care behavior among patients with heart failure.

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Prognostic Value of Admission Serum Calcium Level in Patients with Cardiogenic Shock Complicating Acute Myocardial Infarction

Liang,

Richard Sasmita,

Jiang

et al. 2024

Preprint

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Admission hyponatraemia as heart failure events predictor in patients with acute heart failure

Cited by 3 publications

References 26 publications

The impact of renal tubulointerstitial dysfunction on the early and long-term prognosis in chronic heart failure patients with preserved left ventricular ejection fraction

The impact of renal tubulointerstitial dysfunction on the early and long-term prognosis in chronic heart failure patients with preserved left ventricular ejection fraction

Self Care Behavior among Patients with Heart Failure in Hasan Sadikin General Hospital Bandung Indonesia

Prognostic Value of Admission Serum Calcium Level in Patients with Cardiogenic Shock Complicating Acute Myocardial Infarction

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